[1]吕易非 李紫凡 邵褀睿 韩江莉.急性冠脉综合征合并高出血风险患者双联抗血小板治疗研究进展[J].心血管病学进展,2023,(7):577.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.001]
 LV Yifei,LI Zifan,SHAO Qirui,et al.Dual Antiplatelet Therapy for Patients with Acute Coronary Syndrome and High Bleeding Risk[J].Advances in Cardiovascular Diseases,2023,(7):577.[doi:10.16806/j.cnki.issn.1004-3934.2023.07.001]
点击复制

急性冠脉综合征合并高出血风险患者双联抗血小板治疗研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年7期
页码:
577
栏目:
综述
出版日期:
2023-07-25

文章信息/Info

Title:
Dual Antiplatelet Therapy for Patients with Acute Coronary Syndrome and High Bleeding Risk
作者:
吕易非 李紫凡 邵褀睿 韩江莉
(北京大学第三医院心内科,北京 100191)
Author(s):
LV YifeiLI ZifanSHAO QiruiHAN Jiangli
(Department of Cardiology,Peking University Third Hospital,Beijing 100191,China)
关键词:
急性冠脉综合征高出血风险抗血小板治疗
Keywords:
Acute coronary syndromeHigh bleeding riskAntiplatelet therapy
DOI:
10.16806/j.cnki.issn.1004-3934.2023.07.001
摘要:
阿司匹林联合一种P2Y12受体抑制剂双联抗血小板治疗是急性冠脉综合征患者的重要治疗措施之一。急性冠脉综合征合并高出血风险患者在临床上属于特殊风险人群,常被相关临床研究排除在外,因而双联抗血小板治疗策略选择缺乏充分的循证医学证据。现综述急性冠脉综合征合并高出血风险患者抗血小板治疗研究进展,以期为临床医生面对此类患者时选择合适的抗血小板治疗方案提供借鉴。
Abstract:
Dual antiplatelet therapy(aspirin combined with a P2Y12 receptor inhibitor)is one of the important treatment s for patients with acute coronary syndrome(ACS). ACS patients with high bleeding risk belong to a special risk group clinically ,and they are often excluded from relevant clinical studies. Therefore,the choice of d ual antiplatelet therapy strategy lacks sufficient evidence-based medicine for these patients. This article reviews the research progress of antiplatelet therapy in patients with ACS complicated with high bleeding risk,in order to provide reference for clinicians to choose appropriate antiplatelet therapy for such patients

参考文献/References:

[1] Lee YJ,Suh Y,Kim JS,et al. Ticagrelor monotherapy after 3-month dual antiplatelet therapy in acute coronary syndrome by high bleeding risk:the subanalysis from the TICO trial[J]. Korean Circ J,2022,52(4):324-337. [2] Kang J,Kim HS. The evolving concept of dual antiplatelet therapy after percutaneous coronary intervention:focus on unique feature of East Asian and “Asian Paradox”[J]. Korean Circ J,2018,48(7):537-551. [3] Faber DR,de Groot PG,Visseren FL. Role of adipose tissue in haemostasis,coagulation and fibrinolysis[J]. Obes Rev,2009,10(5):554-563. [4] Jeong YH. “East asian paradox”:challenge for the current antiplatelet strategy of “one-guideline-fits-all races” in acute coronary syndrome[J]. Curr Cardiol Rep,2014,16(5):485. [5] Yang M,Ye Z,Mei L,et al. Pharmacodynamic effects of indobufen compared with aspirin in patients with coronary atherosclerosis[J]. Eur J Clin Pharmacol,2021,77(12):1815-1823.[6] Storey RF,Husted S,Harrington RA,et al. Inhibition of platelet aggregation by AZD6140,a reversible oral P2Y12 receptor antagonist,compared with clopidogrel in patients with acute coronary syndromes[J]. J Am Coll Cardiol,2007,50(19):1852-1856. [7] Wallentin L,Becker RC,Budaj A,et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes[J]. N Engl J Med,2009,361(11):1045-1057. [8] de Luca L,Zeymer U,Claeys MJ,et al. Comparison of P2Y12 receptor inhibitors in patients with ST-elevation myocardial infarction in clinical practice:a propensity score analysis of five contemporary European registries[J]. Eur Heart J Cardiovasc Pharmacother,2021,7(2):94-103. [9] Zocca P,Kok MM,van der Heijden LC,et al. High bleeding risk patients with acute coronary syndromes treated with contemporary drug-eluting stents and Clopidogrel or Ticagrelor:insights from CHANGE DAPT[J]. Int J Cardiol,2018,268:11-17. [10] Gragnano F,Moscarella E,Calabrò P,et al. Clopidogrel versus ticagrelor in high-bleeding risk patients presenting with acute coronary syndromes:insights from the multicenter START-ANTIPLATELET registry[J]. Intern Emerg Med,2021,16(2):379-387. [11] Wiviott SD,Braunwald E,McCabe CH,et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes[J]. N Engl J Med,2007,357(20):2001-2015. [12] Schüpke S,Neumann FJ,Menichelli M,et al. Ticagrelor or prasugrel in patients with acute coronary syndromes[J]. N Engl J Med,2019,381(16):1524-1534. [13] Zhang J,Qiu M,Na K,et al. Impact of 6- versus 12-month dual antiplatelet therapy on clinical prognosis in patients with high bleeding risk:insights from the 4-year results of the I LOVE IT 2 study[J]. Catheter Cardiovasc Interv,2021,97(suppl 2):1025-1031. [14] Kim BK,Hong SJ,Cho YH,et al. Effect of ticagrelor monotherapy vs ticagrelor with aspirin on major bleeding and cardiovascular events in patients with acute coronary syndrome:the TICO randomized clinical trial[J]. JAMA,2020,323(23):2407-2416. [15] Escaned J,Cao D,Baber U,et al. Ticagrelor monotherapy in patients at high bleeding risk undergoing percutaneous coronary intervention:TWILIGHT-HBR[J]. Eur Heart J,2021,42(45):4624-4634. [16] Costa F,van Klaveren D,James S,et al. Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy(PRECISE-DAPT) score:a pooled analysis of individual-patient datasets from clinical trials[J]. Lancet,2017,389(10073):1025-1034. [17] Valgimigli M,Frigoli E,Heg D,et al. Dual antiplatelet therapy after PCI in patients at high bleeding risk[J]. N Engl J Med,2021,385(18):1643-1655. [18] Kandzari DE,Kirtane AJ,Windecker S,et al. One-month dual antiplatelet therapy following percutaneous coronary intervention with zotarolimus-eluting stents in high-bleeding-risk patients[J]. Circ Cardiovasc Interv,2020,13(11):e009565. [19] Mehran R,Cao D,Angiolillo DJ,et al. 3- or 1-Month DAPT in patients at high bleeding risk undergoing everolimus-eluting stent implantation[J]. JACC Cardiovasc Interv,2021,14(17):1870-1883.[20] Valgimigli M,Cao D,Angiolillo DJ,et al. Duration of dual antiplatelet therapy for patients at high bleeding risk undergoing PCI[J]. J Am Coll Cardiol,2021,78(21):2060-2072. [21] Valgimigli M,Smits PC,Frigoli E,et al. Duration of antiplatelet therapy after complex percutaneous coronary intervention in patients at high bleeding risk:a MASTER DAPT trial sub-analysis[J]. Eur Heart J,2022,43(33):3100-3114.?[22] Doyle BJ,Ting HH,Bell MR,et al. Major femoral bleeding complications after percutaneous coronary intervention:incidence,predictors,and impact on long-term survival among 17,901 patients treated at the Mayo Clinic from 1994 to 2005[J]. JACC Cardiovasc Interv,2008,1(2):202-209. [23] 韩雅玲. 中国经皮冠状动脉介入治疗指南(2016)[J]. 中华心血管病杂志,2016,44(5): 382-400.[24] 中华医学会心血管病学分会动脉粥样硬化与冠心病学组,中华医学会心血管病学分会介入心脏病学组,中国医师协会心血管内科医师分会血栓防治专业委员会,等. 冠心病双联抗血小板治疗中国专家共识[J]. 中华心血管病杂志,2021,49(5):432-454.[25] 中华医学会心血管病学分会,中华心血管病杂志编辑委员会. 急性ST段抬高型心肌梗死诊断和治疗指南(2019)[J]. 中华心血管病杂志,2019,47(10):766-783.[26] Bajraktari G,Rexhaj Z,Elezi S,et al. Radial access for coronary angiography carries fewer complications compared with femoral access:a meta-analysis of randomized controlled trials[J]. J Clin Med,2021,10(10):2163. [27] Ferrante G,Rao SV,Jüni P,et al. Radial versus femoral access for coronary interventions across the entire spectrum of patients with coronary artery disease:a meta-analysis of randomized trials[J]. JACC Cardiovasc Interv,2016,9(14):1419-1434. [28] Valgimigli M,Gagnor A,Calabró P,et al. Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management:a randomised multicentre trial[J]. Lancet,2015,385(9986):2465-2476. [29] Tarighatnia A,Farajollahi AR,Mohammadalian AH,et al. Radiation exposure levels according to vascular access sites during PCI:a prospective controlled study[J]. Herz,2019,44(4):330-335. [30] 中国医师协会心血管内科医师分会,中国医师协会心血管内科医师分会血栓防治专业委员会,中华医学会消化内镜学分会,等. 急性冠状动脉综合征抗栓治疗合并出血防治多学科专家共识[J]. 中华内科杂志,2016,55(10):813-824.[31] Robinson M,Horn J. Clinical pharmacology of proton pump inhibitors:what the practising physician needs to know[J]. Drugs,2003,63(24):2739-2754. [32] Collet JP,Thiele H,Barbato E,et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation[J]. Eur Heart J,2021,42(14):1289-1367. [33] Agewall S,Cattaneo M,Collet JP,et al. Expert position paper on the use of proton pump inhibitors in patients with cardiovascular disease and antithrombotic therapy[J]. Eur Heart J,2013,34(23):1708-1713,1713a-1713b.

相似文献/References:

[1]李润土,何泉.光学相干断层成像在急性冠脉综合征介入治疗中的应用[J].心血管病学进展,2019,(6):856.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.005]
 LI Runtu,HE Quan.Application of Optical Coherent Tomography in Interventional Treatment of Acute Coronary Syndrome[J].Advances in Cardiovascular Diseases,2019,(7):856.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.005]
[2]郑晓雪 季福绥.急性冠脉综合征患者发生急性肾损伤的临床进展[J].心血管病学进展,2019,(5):713.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.013]
 ZHENG Xiaoxue,JI Fusui.Acute Kidney Injury in Patients with Acute Coronary Syndrome[J].Advances in Cardiovascular Diseases,2019,(7):713.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.013]
[3]周小琳 何泉.替格瑞洛在急性冠脉综合征合并慢性肾脏病患者中的应用研究进展[J].心血管病学进展,2019,(5):718.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.014]
 ZHOU Xiaolin,HE Quan.Ticagrelor in Acute Coronary Syndrome with Chronic Kidney Disease[J].Advances in Cardiovascular Diseases,2019,(7):718.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.014]
[4]吕俊兴 许海燕.急性冠脉综合征危险评分的研究进展[J].心血管病学进展,2019,(9):1224.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.010]
 LU Junxing,XU Haiyan.Risk Scores of Acute Coronary Syndrome[J].Advances in Cardiovascular Diseases,2019,(7):1224.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.010]
[5]吕颖 胡思宁 于波 贾海波.斑块侵蚀发病机制的最新研究进展[J].心血管病学进展,2020,(1):74.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.020]
 LU Ying,HU Sining,YU Bo,et al.Pathogenic Mechanisms of Plaque Erosion[J].Advances in Cardiovascular Diseases,2020,(7):74.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.020]
[6]段继坤,林志,杨帆,等.斑块侵蚀引起的急性冠脉综合征的研究新进展[J].心血管病学进展,2020,(3):281.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.016]
 DUAN Jikun,LIN Zhi,YANG Fan,et al.Acute Coronary Syndrome Caused by Plaque Erosion[J].Advances in Cardiovascular Diseases,2020,(7):281.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.016]
[7]陈凯磊 胡闻竹 苏冠华.P2Y12抑制剂与癌症风险的相关性研究进展[J].心血管病学进展,2020,(8):798.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.004]
 CHEN Kailei,HU Wenzhu,SU Guanhua.Advances in Studies on the Correlation between P2Y12 Inhibitors and Cancer Risk[J].Advances in Cardiovascular Diseases,2020,(7):798.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.004]
[8]肖雨尘 赵仙先 马丽萍.急性冠脉综合征患者提前停服替格瑞洛现象的研究进展[J].心血管病学进展,2020,(11):1120.[doi:10.16806/j.cnki.issn.1004-3934.2020.11.000]
 Acute Coronary Syndrome.Premature Ticagrelor Discontinuation in Patients with[J].Advances in Cardiovascular Diseases,2020,(7):1120.[doi:10.16806/j.cnki.issn.1004-3934.2020.11.000]
[9]冯洁渊 .中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值与急性冠脉综合征的关系研究进展[J].心血管病学进展,2020,(12):1276.[doi:10.16806/j.cnki.issn.1004-3934.2020.12.013]
  FENG Jieyuan.The Relationship Between Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio and Acute Coronary Syndrome[J].Advances in Cardiovascular Diseases,2020,(7):1276.[doi:10.16806/j.cnki.issn.1004-3934.2020.12.013]
[10]魏倩 梁岩.高敏心肌肌钙蛋白在急性冠脉综合征患者中的临床应用进展[J].心血管病学进展,2021,(5):396.[doi:10.16806/j.cnki.issn.1004-3934.2021.05.003]

更新日期/Last Update: 2023-08-18