[1]石雷雷 徐园园 杨宁.青年高血压患者微量白蛋白尿的相关因素分析[J].心血管病学进展,2023,(4):381.[doi:10.16806/j.cnki.issn.1004-3934.2023.04.020]
　SHI Leilei,XU Yuanyuan,YANG Ning.Related Factors on Microalbuminuria in Young Patients with Hypertension[J].Advances in Cardiovascular Diseases,2023,(4):381.[doi:10.16806/j.cnki.issn.1004-3934.2023.04.020]
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青年高血压患者微量白蛋白尿的相关因素分析()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年4期
页码:
381
栏目:
论著
出版日期:
2023-04-25

文章信息/Info

Title:
Related Factors on Microalbuminuria in Young Patients with Hypertension
作者:
石雷雷1 徐园园2 杨宁1
1.泰达国际心血管病医院高血压科,天津 3004572.天津医科大学第二医院心内科,天津 300211【
Author(s):
SHI Leilei1;  XU Yuanyuan2;  YANG Ning1
(1. Department of Hypertension,TEDA International Cardiovascular Hospital, Tianjin 300457,China;2.Department of Cardiology,The Second Hospital of Tianjin Medical University, Tianjin 300211,China)
关键词:
血压; 微量白蛋白尿; 青年
Keywords:
Hypertension;  Microalbuminuria;  Young
DOI:
10.16806/j.cnki.issn.1004-3934.2023.04.020
摘要:
目的 本研究旨在分析青年高血压患者微量白蛋白尿（MAU）的相关因素，为临床实践提供一定参考。方法 采用病例对照研究设计，2020年4月2021年7月收治的341青年高血压患者（1845岁）为研究对象，根据MAU测定结果将入组患者分为对照组（单纯高血压患者）和病例组（合并MAU的高血压患者），，。根据资料类型采用相应统计学方法比较两组间的临床资料并应用二元ogistic回归分析探索青年高血压患者MAU的相关因素。结果 该研究人群中MAU发生率为27.0%（95% CI 22.2%31.7%）。与对照组比较，病例组收缩压（139±17mm Hg vs（133±14）mm Hg）及舒张压（87±12mm Hg vs（83±12）mm Hg]水平更高（P均＜0.05）。此外，病例组体重指数（28.5±4.5kg/m2 vs（26.9±3.9）kg/m2]、立位醛固酮（17.2±11.3ng/mL vs（13.8±7.5）ng/mL]、尿酸（420.4±109.1μmol/L vs（390.5±89.3）μmol/L]及血肌酐（69.3±14.4μmol/L vs（66.1±12.2）μmol/L]也显著高于对照组（P均＜0.05）。多因素分析发现，收缩压、高水平的立位醛固酮及尿酸与青年高血压患者MAU的发生相关。结论 收缩压、高水平的立位醛固酮及尿酸可能与青年高血压患者早期肾脏损害的发生密切相关。
Abstract:
Objective To study related factors on microalbuminuria (MAU) in young patients with hypertension to provide references for clinical practice. Methods It was a cross-sectional study. A total of 341 young hypertensive patients aged 18 to 45 years old who admitted in TEDA International Cardiovascular Hospital from April 2020 to July 2021 were enrolled, and classified into two groups according to whether complicated by MAU, 249 of whom without MAU (Control group) and 92 with MAU (Case group). Clinical data were compared by corresponding statistics based on data types. Binary logistic regression was used to analyze related factors on MAU. Results The incidence of MAU in this population was 27.0% (95% CI 22.2%~31.7%). Systolic blood pressure [(139±17) mm Hg vs (133±14) mm Hg)(1 mm Hg=0.133 3 kPa], and diastolic blood pressure [(87±12) mm Hg vs (83±12) mm Hg)] were higher in case group than control group (all P<0.05). Patients in case group showed higher body mass index [(28.5±4.5)kg/m2 vs (26.9±3.9)kg/m2],standing aldosterone [(17.2±11.3) ng/mL vs (13.8±7.5) ng/mL], uric acid [(420.4±109.1) μmol/L vs (390.5±89.3) μmol/], and creatinine [(69.3±14.4) μmol/L vs (66.1±12.2) μmol/L] levels as compared to control group (all P<0.05). Binary logistic regression analysis showed that systolic pressure, a high level of standing aldosterone and uric acid were related to MAU in young hypertensive patients (all P<0.05). Conclusion Systolic pressure, a high level of standing aldosterone and uric acid may be closely related to early renal damage in young patients with hypertension

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备注/Memo

备注/Memo:
收稿日期：2022-10-19
更新日期/Last Update: 2023-05-17