[1]陈威锟 刘远辉 甄慈恩 张业燊 范华林 何鹏程 谭宁 吴君.急性冠脉综合征患者经皮冠状动脉介入治疗围手术期的胃肠外抗凝治疗进展[J].心血管病学进展,2023,(1):35-38,43.[doi:10.16806/j.cnki.issn.1004-3934.2023.01.009]
 CHEN Weikun,LIU Yuanhui,ZHEN Cien,et al.Perioperative Parenteral Anticoagulant Therapy in Patients with Acute Coronary Syndrome During Percutaneous Coronary Intervention[J].Advances in Cardiovascular Diseases,2023,(1):35-38,43.[doi:10.16806/j.cnki.issn.1004-3934.2023.01.009]
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急性冠脉综合征患者经皮冠状动脉介入治疗围手术期的胃肠外抗凝治疗进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2023年1期
页码:
35-38,43
栏目:
综述
出版日期:
2023-01-25

文章信息/Info

Title:
Perioperative Parenteral Anticoagulant Therapy in Patients with Acute Coronary Syndrome During Percutaneous Coronary Intervention
作者:
陈威锟1 刘远辉 1 甄慈恩12 张业燊 1 范华林 12 何鹏程 1 谭宁 1 吴君 1
(1.广东省心血管病研究所 广东省人民医院心内科,广东 广州 510080;2.华南理工大学医学院,广东 广州 510080)
Author(s):
CHEN Weikun1LIU Yuanhui1ZHEN Cien12ZHANG Yeshen1FAN Hualin12HE Pengcheng1TAN Ning1WU Jun1
(1.Department of Cardiology,Guangdong Cardiovascular Institute,Guangdong Provincial People’s Hospital,Guangzhou 510080,Guangdong,China; 2.School of Medicine of South China University of Technology,Guangzhou 510080,Guangdong,China)
关键词:
急性冠脉综合征经皮冠状动脉介入治疗胃肠外抗凝治疗
Keywords:
Acute coronary syndromePercutaneous coronary interventionParenteral anticoagulation therapy
DOI:
10.16806/j.cnki.issn.1004-3934.2023.01.009
摘要:
经皮冠状动脉介入治疗(PCI)是急性冠脉综合征的主要治疗方式。PCI围手术期抗血小板治疗联合抗凝治疗减少了急性冠脉综合征患者血栓事件的发生,同时也使出血风险随之增加,近年来有研究提示围手术期胃肠外抗凝治疗收益与风险需重新评估。现综述PCI围手术期胃肠外抗凝治疗常用药物及其优缺点,并阐述围手术期胃肠外抗凝治疗新研究进展。
Abstract:
Percutaneous coronary intervention(PCI) is the main treatment for acute coronary syndrome. PCI perioperative antiplatelet combined anticoagulant therapy reduces the occurrence of thrombotic events in patients with acute coronary syndrome and increases the risk of bleeding. In recent years,studies have suggested that the benefits and risks of perioperative parenteral anticoagulant therapy need to be re-evaluated. In this paper,we will review the advantages and disadvantages of commonly used perioperative parenteral anticoagulants for PCI,and describe the new research progress of perioperative parenteral anticoagulants

参考文献/References:

[1].Rao SV,Ohman EM. Anticoagulant therapy for percutaneous coronary intervention[J]. Circ Cardiovasc Interv,2010,3(1):80-88.
[2].Gopalakrishnan M,Lotfi AS. Stent thrombosis[J]. Semin Thromb Hemost,2018,44(1):46-51.
[3].Burzotta F,Parma A,Pristipino C,et al. Angiographic and clinical outcome of invasively managed patients with thrombosed coronary bare metal or drug-eluting stents:the OPTIMIST study[J]. Eur Heart J,2008,29(24):3011-3021.
[4].Hirsh J,Anand SS,Halperin JL,et al. Mechanism of action and pharmacology of unfractionated heparin[J]. Arterioscler Thromb Vasc Biol,2001,21(7):1094-1096.
[5].Ibánez B,James S,Agewall S,et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation[J]. Rev Esp Cardiol(Engl Ed),2017,70(12):1082.
[6].Dillinger JG,Ducrocq G,Elbez Y,et al. Activated clotting time to guide heparin dosing in non-ST-segment-elevation acute coronary syndrome patients undergoing percutaneous coronary intervention and treated withⅡb/Ⅲa inhibitors:impact on ischemic and bleeding outcomes:insights from the TAO trial[J]. Circ Cardiovasc Interv,2018,11(6):e006084.
[7].Weitz JI. Low-molecular-weight heparins[J]. N Engl J Med,1997,337(10):688-698.
[8].Arsenault KA,Hirsh J,Whitlock RP,et al. Direct thrombin inhibitors in cardiovascular disease[J]. Nat Rev Cardiol,2012,9(7):402-414.
[9].Keam SJ,Goa KL. Fondaparinux sodium[J]. Drugs,2002,62(11):1673-1685.
[10].Fifth Organization to Assess Strategies in Acute Ischemic Syndromes Investigators,Yusuf S,Mehta SR,et al. Comparison of fondaparinux and enoxaparin in acute coronary syndromes[J]. N Engl J Med ,2006,354 (14):1464-1476.
[11].Yusuf S,Mehta SR,Chrolavicius S,et al. Effects of fondaparinux on mortality and reinfarction in patients with acute ST-segment elevation myocardial infarction:the OASIS-6 randomized trial[J]. JAMA,2006,295(13):1519-1530.
[12].Cohen M,Adams PC,Parry G,et al. Combination antithrombotic therapy in unstable rest angina and non-Q-wave infarction in nonprior aspirin users. Primary end points analysis from the ATACS trial. Antithrombotic Therapy in Acute Coronary Syndromes Research Group[J]. Circulation,1994,89(1):81-88.
[13].Gurfinkel EP,Manos EJ,Mejaíl RI,et al. Low molecular weight heparin versus regular heparin or aspirin in the treatment of unstable angina and silent ischemia[J]. J Am Coll Cardiol,1995,26(2):313-318.
[14].Chen JY,He PC,Liu YH,et al. Association of parenteral anticoagulation therapy with outcomes in Chinese patients undergoing percutaneous coronary intervention for non-ST-segment elevation acute coronary syndrome[J]. JAMA Intern Med,2019,179(2):186-194.
[15].Liu YH,Fan HL,Zeng LH,et al. Association of parenteral anticoagulation therapy with outcomes in non-ST-segment elevation acute coronary syndrome patients without invasive therapy:findings from the improving Care for Cardiovascular Disease in China (CCC) project[J]. Clin Pharmacol Ther,2021,110(4):1119-1126.
[16].Li YJ,Rha SW,Chen KY,et al. Low molecular weight heparin versus unfractionated heparin in patients with acute non-ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention with drug-eluting stents[J]. J Cardiol,2012,59(1):22-29.
[17].Mallidi JR,Robinson P,Visintainer PF,et al. Comparison of antithrombotic agents during urgent percutaneous coronary intervention following thrombolytic therapy:a retrospective cohort study[J]. Catheter Cardiovasc Interv,2017,90 (6):898-904.
[18].Valgimigli M,Frigoli E,Leonardi S,et al. Bivalirudin or unfractionated heparin in acute coronary syndromes[J]. N Engl J Med,2015,373(11):997-1009.
[19].O’Gara PT,Kushner FG,Ascheim DD,et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction:a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines[J]. J Am Coll Cardiol,2013,61(4):e78-e140.
[20].Collet JP,Thiele H,Barbato E,et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation[J]. Eur Heart J,2021,42(14):1289-1367.
[21].中华医学会心血管病学分会,中华心血管病杂志编辑委员会. 急性ST段抬高型心肌梗死诊断和治疗指南[J]. 中华心血管病杂志,2015,43(5):380-393.
[22].中华医学会心血管病学分会,中华心血管病杂志编辑委员会. 非ST段抬高型急性冠状动脉综合征诊断和治疗指南(2016)[J]. 中华心血管病杂志,2017,45(5):359-376.
[23].韩雅玲,傅向华. 经皮冠状动脉介入治疗围手术期非口服抗凝药物临床应用中国专家共识[J]. 中华心血管病杂志,2018,46(6):428-437.
[24].Madhavan MV,Généreux P,Kirtane AJ,et al. Is routine post-procedural anticoagulation warranted after primary percutaneous coronary intervention in ST-segment elevation myocardial infarction? Insights from the HORIZONS-AMI trial[J]. Eur Heart J Acute Cardiovasc Care,2017,6(7):650-658.
[25].Ducrocq G,Steg PG,Van’t Hof A,et al. Utility of post-procedural anticoagulation after primary PCI for STEMI:insights from a pooled analysis of the HORIZONS-AMI and EUROMAX trials[J]. Eur Heart J Acute Cardiovasc Care,2017,6(7):659-665.
[26].Gargiulo G,Carrara G,Frigoli E,et al. Post-procedural bivalirudin infusion at?full or low regimen in patients with?acute coronary syndrome[J]. J Am Coll Cardiol,2019,73(7): 758-774.
[27].Yan Y,Gong W,Ma C,et al. Postprocedure anticoagulation in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention[J]. JACC Cardiovasc Interv,2022,15(3):251-263.
[28].Gragnano F,Calabrò P. Anticoagulation after primary PCI:the land of promises and uncertainty[J]. JACC Cardiovasc Interv,2022,15(3):264-267.
[29].Yan Y,Wang X,Guo J,et al. Rationale and design of the RIGHT trial:a multicenter,randomized,double-blind,placebo-controlled trial of anticoagulation prolongation versus no anticoagulation after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction[J]. Am Heart J,2020,227:19-30.

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更新日期/Last Update: 2023-03-10