[1]刘畅畅 苏利芳 汪雁博.钠-葡萄糖耦联转运体2抑制剂在急性心肌梗死合并糖尿病患者中的应用前景展望[J].心血管病学进展,2022,(11):1028.[doi:10.16806/j.cnki.issn.1004-3934.2022.11.015]
 LIU Changchang,SU Lifang,WANG Yanbo.Prospect of Application of Sodium-Glucose Linked Transporter 2 Inhibitors in Patients with Acute Myocardial Infarction and Diabetes Mellitus[J].Advances in Cardiovascular Diseases,2022,(11):1028.[doi:10.16806/j.cnki.issn.1004-3934.2022.11.015]
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钠-葡萄糖耦联转运体2抑制剂在急性心肌梗死合并糖尿病患者中的应用前景展望()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年11期
页码:
1028
栏目:
综述
出版日期:
2022-11-25

文章信息/Info

Title:
Prospect of Application of Sodium-Glucose Linked Transporter 2 Inhibitors in Patients with Acute Myocardial Infarction and Diabetes Mellitus
作者:
刘畅畅 苏利芳 汪雁博
?河北医科大学第二医院心血管内科,河北 石家庄 050000)
Author(s):
LIU ChangchangSU LifangWANG Yanbo
(Department of Cardiology,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei,China)
关键词:
钠-葡萄糖耦联转运体2抑制剂急性心肌梗死2型糖尿病
Keywords:
Sodium-glucose linked transporter 2 inhibitors Acute myocardial infarctionType 2 diabetes mellitus
DOI:
10.16806/j.cnki.issn.1004-3934.2022.11.015
摘要:
急性心肌梗死(AMI)患者的远期预后差,病死率逐年增加,合并糖尿病的AMI患者预后更差。钠-葡萄糖耦联转运体2(SGLT2)抑制剂是一种新型的口服降糖药物,具有明显的心血管获益。目前发现SGLT-2抑制剂作用机制广泛,不仅具有降糖作用,而且具有改善心脏泵血功能、强化抗凝及抗血小板效果、调节离子交换、促进酮体生成、降低交感神经活性和减少炎症反应等作用。现通过总结SGLT-2抑制剂在AMI合并糖尿病患者中应用的作用机制,为AMI合并糖尿病患者的治疗提供新思路。
Abstract:
The long-term prognosis of patients with acute myocardial infarction(AMI) is poor,the fatality rate is increasing year by year,and the prognosis of AMI patients with diabetes is even worse. Sodium-glucose linked transporter 2(SGLT2) inhibitors are a new class of oral hypoglycemic agents with significant cardiovascular benefits. At present,it is found that SGLT-2 inhibitors have a wide range of mechanisms of action,not only have hypoglycemic effects,but also have the effects of improving heart pumping function,strengthening anticoagulation and antiplatelet effects,regulating ion exchange,promoting ketone body production,reducing sympathetic nerve activity and reducing inflammatory reaction. This article summarizes the mechanism of SGLT-2 inhibitor in the treatment of AMI patients with diabetes,and provides a new idea for the treatment of AMI patients with diabetes

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更新日期/Last Update: 2023-01-31