[1]代虎威 王馨焱 李松珊 温泽宇 曾康 杨滨.免疫检查点抑制剂相关心肌炎的诊断及管理研究进展[J].心血管病学进展,2022,(10):937.[doi:10.16806/j.cnki.issn.1004-3934.2022.10.017]
 Immune Checkpoint Inhibitor-Associated Myocarditis.Diagnosis and Management of[J].Advances in Cardiovascular Diseases,2022,(10):937.[doi:10.16806/j.cnki.issn.1004-3934.2022.10.017]
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免疫检查点抑制剂相关心肌炎的诊断及管理研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年10期
页码:
937
栏目:
综述
出版日期:
2022-10-25

文章信息/Info

Title:
Diagnosis and Management of
作者:
代虎威 王馨焱 1 李松珊 1 温泽宇1 曾康 1 杨滨 2
(1.山西医科大学,山西 太原 030000;2.山西医科大学第二医院心血管内科,山西 太原 030000)
Author(s):
Immune Checkpoint Inhibitor-Associated Myocarditis
DAI Huwei1WANG Xinyan1LI Songshan1WEN Zeyu1ZENG Kang1YANG Bin2 (1.Shanxi Medical University,Taiyuan 030000,Shanxi,China2.Department of Cardiovascular Medicine,Second Hospital of Shanxi Medical University,Taiyuan 030000,Shanxi,China)
关键词:
免疫检查点抑制剂心肌炎心脏毒性
Keywords:
Immune checkpoint inhibitorsMyocarditisCardiotoxicity
DOI:
10.16806/j.cnki.issn.1004-3934.2022.10.017
摘要:
随着肿瘤学中免疫治疗的迅速发展,免疫检查点抑制剂(ICI)已在肿瘤治疗领域扮演了极其重要的角色。针对细胞毒性T淋巴细胞相关抗原-4、程序性细胞死亡受体-1及其配体程序性死亡配体-1等免疫检查点的抑制剂被广泛应用于各种肿瘤,其患者生存率显著提升的同时,也出现一系列的免疫相关不良反应,而ICI相关心肌炎是其中致死率最高的一种。现就ICI相关心肌炎的诊断及管理研究进展进行综述。
Abstract:
With the rapid development of immunotherapy in oncology,immune checkpoint inhibitors (ICIs) have played an extremely important role in the field of oncology treatment. Inhibitors of immune checkpoints such as cytotoxic T lymphocyte-associated antigen-4 (CTLA-4),programmed cell death receptor-1 (PD-1) and its ligand programmed death ligand-1 (PD-L1) are widely used in various cancers,and while the survival rate of tumour patients has increased significantly,a series of immune-related adverse effects have also emerged,with ICI-associated myocarditis being one of the most lethal. This article reviews the progress of research on the diagnosis and management of ICI-associated myocarditis

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更新日期/Last Update: 2022-12-26