[1]李玉洁 张瑜 吴诚洁 陆琳 王燕丽 李杨欣.核糖体泛素化在心血管疾病中的研究进展[J].心血管病学进展,2022,(10):910.[doi:10.16806/j.cnki.issn.1004-3934.2022.10.011]
　Li Yujie,Zhang Yu,Wu Chengjie,et al.Ribosomal Ubiquitination in Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2022,(10):910.[doi:10.16806/j.cnki.issn.1004-3934.2022.10.011]
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核糖体泛素化在心血管疾病中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年10期
页码:
910
栏目:
综述
出版日期:
2022-10-25

文章信息/Info

Title:
Ribosomal Ubiquitination in Cardiovascular Disease
作者:
李玉洁 张瑜 吴诚洁 陆琳 王燕丽 李杨欣
(苏州大学医学院心血管病研究所 苏州大学附属第一医院 心脏大血管外科,江苏 苏州 215123 )
Author(s):
Li Yujie; Zhang Yu; Wu Chengjie; Lu Lin; Wang Yanli; Li Yangxin
(Institute for Cardiovascular Science,Medical College of Soochow University;Department of Cardiovascular Surgery,The First Affiliated Hospital of Soochow University ,Jiangsu,Suzhou 215123)
关键词:
核糖体; 泛素化; 心血管疾病
Keywords:
Ribosome;  Ubiquitination;  Cardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2022.10.011
摘要:
心血管疾病是全球发病率及致死率最高的疾病之一。核糖体是细胞中合成蛋白质的细胞器。研究证实泛素化系统在心血管疾病中具有重要的生理和病理生理学意义。越来越多的证据表明，核糖体的泛素化可能参与心血管疾病的发生发展，有望成为心血管疾病诊断的标志物以及治疗靶标。本文就核糖体泛素化在心肌梗死、缺血后再灌注损伤、心肌肥厚和心肌重构等心血管疾病中的研究进展进行综述。
Abstract:
Cardiovascular disease is the leading cause of death globally.??Ribosome is cellular organelle that synthesize proteins. Studies have confirmed that the ubiquitination system plays an important physiological and pathological role in the development of cardiovascular diseases. Emerging evidence shows that ribosomal ubiquitination may be involved in regulating the occurrence and development of myocardial infarction,?post-ischemic reperfusion injury,?myocardial hypertrophy and cardiac remodeling. It is expected to become a target for the diagnosis and treatment of cardiovascular diseases. This paper reviews the research progress of ribosomal ubiquitination in cardiovascular diseases

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更新日期/Last Update: 2022-12-26