[1]霍照美 田龙海 杨龙.心肌内向整流钾电流的调控因素及相关心律失常[J].心血管病学进展,2022,(7):640-644.[doi:10.16806/j.cnki.issn.1004-3934.2022.07.000]
 HUO Zhaomei,TIAN Longhai,YANG Long.Regulatory Factors and Related Arrhythmias of Inward Rectifier Potassium Current[J].Advances in Cardiovascular Diseases,2022,(7):640-644.[doi:10.16806/j.cnki.issn.1004-3934.2022.07.000]
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心肌内向整流钾电流的调控因素及相关心律失常()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年7期
页码:
640-644
栏目:
综述
出版日期:
2022-07-25

文章信息/Info

Title:
Regulatory Factors and Related Arrhythmias of Inward Rectifier Potassium Current
文章编号:
202202090
作者:
霍照美12 田龙海2 杨龙 12
(1.贵州医科大学,贵州 贵阳 550025;2.贵州省人民医院心内科,贵州 贵阳 550002)
Author(s):
HUO Zhaomei12TIAN Longhai2YANG Long12
(1.Guizhou Medical University,Guiyang 550025,Guizhou,China; 2.Department of Cardiology,Guizhou Provincial People’s Hospital,Guiyang 550002 ,Guizhou,China)
关键词:
内向整流钾电流离子通道心律失常
Keywords:
Inward rectifier potassium current Ion channelArrhythmia
DOI:
10.16806/j.cnki.issn.1004-3934.2022.07.000
摘要:
心肌内向整流钾电流(IK1)由内向整流钾电流通道(Kir通道)家族成员Kir2.1通道介导。细胞膜电位静息水平时Kir2.1通道处于开放状态,K+外流增加;而当膜去极化时,Kir2.1通道的通透性降低,K+外流减少。IK1是形成心肌细胞静息膜电位的主要成分,在多种心律失常中发挥重要的作用。现就IK1的调控及其相关心律失常做一综述。
Abstract:
Myocardial inward rectifier potassium current (IK1) is mediated by Kir2.1 channel,a member of inward rectifier potassium channel(K ir channel) family. When the cell membrane potential a t the resting level,Kir2.1 channel was open and K+ outflow increased.?However, the permeability of Kir2.1 channel decreases with cell membrane depolarization,resulting in the decrease of K+ outflow. IK1 is the main component of resting potential of cardiomyocytes,and plays an important role in arrhythmias. The purpose of this paper is to review the research progress about both the regulation and related arrhythmias of IK1

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更新日期/Last Update: 2022-08-22