[1]谢星星 刘学 雷丹丹 余志刚.选择性凝血因子Xa抑制剂:磺达肝癸钠的临床应用研究进展[J].心血管病学进展,2022,(7):652-656.[doi:10.16806/j.cnki.issn.1004-3934.2022.07.000]
 XIE Xingxing,LIU Xue,LEI Dandan,et al.Clinical Application of Selective Coagulation Factor Xa Inhibitors:Fondaparinux[J].Advances in Cardiovascular Diseases,2022,(7):652-656.[doi:10.16806/j.cnki.issn.1004-3934.2022.07.000]
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选择性凝血因子Xa抑制剂:磺达肝癸钠的临床应用研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年7期
页码:
652-656
栏目:
综述
出版日期:
2022-07-25

文章信息/Info

Title:
Clinical Application of Selective Coagulation Factor Xa Inhibitors:Fondaparinux
文章编号:
202202053
作者:
谢星星 刘学 雷丹丹 余志刚
(雅安市人民医院药剂科,四川 雅安 625000)
Author(s):
XIE XingxingLIU XueLEI DandanYU Zhigang
(Department of Pharmacy, Yaan Peoples Hospital, Yaan 625000, Sichuan,China)
关键词:
磺达肝癸钠选择性凝血因子Xa抑制剂静脉血栓栓塞心房颤动抗凝临床应用
Keywords:
FondaparinuxSelective coagulation factor Xa inhibitorsVenous thromboembolismAnticoagulation of atrial fibrillationClinical application
DOI:
10.16806/j.cnki.issn.1004-3934.2022.07.000
摘要:
磺达肝癸钠为全球首个人工合成的长效选择性凝血因子Xa抑制剂,多项临床前研究证实其是一种有效和安全的抗凝药物,2001年首次在美国上市,随后分别于2002年和2007年在欧洲和日本上市。迄今为止,已被批准用于静脉血栓栓塞症、急性冠状动脉综合征及深静脉血栓的预防和治疗。近几年,磺达肝癸钠在心房颤动抗凝、肝门静脉血栓栓塞、新型冠状病毒肺炎患者的抗血栓和抗炎、肝素诱导的血小板减少症的临床应用中也有了长足发展。现综述磺达肝癸钠在上述疾病治疗方面的临床应用,以供临床参考。
Abstract:
Fondaparinux is the world’s first synthetic long-acting selective coagulation factor Xa inhibitor and has been proven to be an effective and safe anticoagulant in preclinical studies. It was first listed in the United States in 2001,followed by Europe in 2002 and Japan in 2007. So far,fondaparinux has been approved for the prevention and treatment of venous thromboembolism,acute coronary syndrome and deep vein thrombosis. In recent years,it has also made great progress in the clinical application of anticoagulant in atrial fibrillation,portal venous thromboembolism,anti-thrombotic and anti-inflammatory in patients with COVID-19,and heparin-induced thrombocytopenia. This article reviews the clinical application of fondaparinux in the treatment of the above diseases for clinical reference

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更新日期/Last Update: 2022-08-22