[1]杨丰菁 李翠兰 刘文玲.遗传性原发性心律失常综合征的心房表型[J].心血管病学进展,2022,(3):193-197.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
 YANG Fengjing,LI Cuilan,LIU Wenling.Atrial Phenotype of Inherited Primary Arrhythmia Syndrome[J].Advances in Cardiovascular Diseases,2022,(3):193-197.[doi:10.16806/j.cnki.issn.1004-3934.2022.03.000]
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遗传性原发性心律失常综合征的心房表型()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年3期
页码:
193-197
栏目:
综述
出版日期:
2022-03-25

文章信息/Info

Title:
Atrial Phenotype of Inherited Primary Arrhythmia Syndrome
文章编号:
202111114
作者:
杨丰菁 李翠兰 刘文玲
(北京大学人民医院心内科,北京 100044 )
Author(s):
YANG FengjingLI CuilanLIU Wenling
(Department of Cardiology,Peking University Peoples Hospital,Beijing 100044,China)
关键词:
遗传性原发性心律失常房性心律失常心房颤动
Keywords:
Inherited primary arrhythmia syndromeAtrial arrhythmiaAtrial fibrillation
DOI:
10.16806/j.cnki.issn.1004-3934.2022.03.000
摘要:
遗传性原发性心律失常综合征(IPAS)以恶性室性心律失常为主要特征,近年来其相关研究有了长足进展。由于共同的病理基质,IPAS患者也可发生房性心律失常,包括房性心动过速和心房颤动等, 其心房颤动的患病率为2%~30%。不过,此类房性心律失常并未受到临床重视,其病因也知之甚少。因此,了解不同类型的IPAS伴发的房性心律失常发生率以及心房电异常,对其诊断与治疗有重要意义。现拟对不同类型IPAS患者伴发心房电异常的相关进展进行综述。
Abstract:
Inherited primary arrhythmia syndrome(IPAS) is mainly characterized by malignant ventricular arrhythmia,and its related research has made great progress in recent years. Because of the common pathological matrix,IPAS patients can also produce atrial arrhythmias,including atrial tachycardia and atrial fibrillation. The prevalence of atrial fibrillation is from 2% to 30%. However, this kind of atrial arrhythmia has not received clinical attention,and its etiology is poorly understood. Therefore,understanding the incidence of atrial arrhythmias and atrial electrical abnormalities associated with different types of IPAS is of great significance for its diagnosis and treatment. This paper reviews the related progress of atrial electrical abnormalities in patients with different types of IPAS.

参考文献/References:

[1] Conte G,Schotten U,Auricchio A. The atrial phenotype of the inherited primary arrhythmia syndromes[J]. Arrhythm Electrophysiol Rev,2019,8(1):42-46.

[2] Roselli C,Chaffin MD,Weng LC,et al. Multi-ethnic genome-wide association study for atrial fibrillation[J]. Nat Genet,2018,50(9):1225-1233.

[3] Go AS,Hylek EM,Phillips KA,et al. Prevalence of diagnosed atrial fibrillation in adults:national implications for rhythm management and stroke prevention:the AnTicoagulation and Risk Factors in Atrial Fibrillation(ATRIA) Study[J]. JAMA,2001,285(18):2370-2375.

[4] Johnson JN,Tester DJ,Perry J,et al. Prevalence of early-onset atrial fibrillation in congenital long QT syndrome[J]. Heart Rhythm,2008,5(5):704-709.

[5] Giustetto C,di Monte F,Wolpert C,et al. Short QT syndrome:clinical findings and diagnostic-therapeutic implications[J]. Eur Heart J,2006,27(20):2440-2447.

[6] El-Sherif N,Turitto G,Boutjdir M. Congenital long QT syndrome and torsade de pointes[J]. Ann Noninvasive Electrocardiol,2017,22(6):e12481.

[7] Kirchhof P,Eckardt L,Franz MR,et al. Prolonged atrial action potential durations and polymorphic atrial tachyarrhythmias in patients with long QT syndrome[J]. J Cardiovasc Electrophysiol,2003,14(10):1027-1033.

[8] Satoh T,Zipes DP. Cesium-induced atrial tachycardia degenerating into atrial fibrillation in dogs:atrial torsades de pointes?[J]. J Cardiovasc Electrophysiol,1998,9(9):970-975.

[9] Bellocq C,van Ginneken AC,Bezzina CR,et al. Mutation in the KCNQ1 gene leading to the short QT-interval syndrome[J]. Circulation,2004,109(20):2394-2397.

[10] Deo M,Ruan Y,Pandit SV,et al. KCNJ2 mutation in short QT syndrome 3 results in atrial fibrillation and ventricular proarrhythmia[J]. Proc Natl Acad Sci U S A,2013,110(11):4291-4296.

[11] Villafa?e J,Fischbach P,Gebauer R. Short QT syndrome manifesting with neonatal atrial fibrillation and bradycardia[J]. Cardiology,2014,128(3):236-240.

[12] Kusano KF,Taniyama M,Nakamura K,et al. Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation,electrophysiology,and clinical backgrounds[J]. J Am Coll Cardiol,2008,51(12):1169-1175.

[13] Conte G,Sieira J,Ciconte G,et al. Implantable cardioverter-defibrillator therapy in Brugada syndrome:a 20-year single-centre experience[J]. J Am Coll Cardiol,2015,65(9):879-888.

[14] Hasdemir C,Payzin S,Kocabas U,et al. High prevalence of concealed Brugada syndrome in patients with atrioventricular nodal reentrant tachycardia[J]. Heart Rhythm,2015,12(7):1584-1594.

[15] Junttila MJ,Tikkanen JT,Kentt? T,et al. Early repolarization as a predictor of arrhythmic and nonarrhythmic cardiac events in middle-aged subjects[J]. Heart Rhythm,2014,11(10):1701-1706.

[16] Shan J,Xie W,Betzenhauser M,et al. Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia[J]. Circ Res,2012,111(6):708-717.

[17] Magnani JW,Williamson MA,Ellinor PT,et al. P wave indices:current status and future directions in epidemiology,clinical,and research applications[J]. Circ Arrhythm Electrophysiol,2009,2(1):72-79.

[18] Conte G,Caputo ML,Volders PGA,et al. Concealed abnormal atrial phenotype in patients with Brugada syndrome and no history of atrial fibrillation[J]. Int J Cardiol,2018,253:66-70.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81270166)
通信作者:刘文玲,E-mail:wlliu@21cn.com)

收稿日期:2021-11-24

更新日期/Last Update: 2022-04-20