[1]师雅 姜崴.特异性促炎症消退介质在糖尿病血管病变中的研究进展[J].心血管病学进展,2022,(4):322-325.[doi:10.16806/j.cnki.issn.1004-3934.2022.04.009]
 SHI Ya,JIANG Wei.Specialized Pro-Resolving Lipid Mediator in Diabetic Vasculopathy[J].Advances in Cardiovascular Diseases,2022,(4):322-325.[doi:10.16806/j.cnki.issn.1004-3934.2022.04.009]
点击复制

特异性促炎症消退介质在糖尿病血管病变中的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年4期
页码:
322-325
栏目:
综述
出版日期:
2022-04-25

文章信息/Info

Title:
Specialized Pro-Resolving Lipid Mediator in Diabetic Vasculopathy
作者:
师雅 姜崴
(哈尔滨医科大学附属第一医院内分泌科,黑龙江 哈尔滨 150000)
Author(s):
SHI Ya JIANG Wei
(Department of EndocrinologyThe First Affiliated Hospital of Harbin Medical UniversityHarbin 150000HeilongjiangChina)
关键词:
特异性促炎症消退介质糖尿病血管病变炎症
Keywords:
Specialized pro-resolving lipid mediator Diabetic vasculopathy Inflammation
DOI:
10.16806/j.cnki.issn.1004-3934.2022.04.009
摘要:
特异性促炎症消退介质(SPM)介导炎症消退过程,其生物作用包括减弱内皮细胞活化、阻断中性粒细胞外渗、调节免疫细胞功能、促进中性粒细胞凋亡及巨噬细胞吞噬作用等。慢性炎症是糖尿病(DM)及相关血管并发症的致病因素,SPM可促进炎症的消退并减轻DM的微血管和大血管并发症,有望成为治疗DM及其血管病变新的治疗靶点,现就近年来SPM在DM及其血管病变相关研究进展做一综述。
Abstract:
The specialized pro-resolving lipid mediator (SPM) mediates the process of inflammation resolution,and it regulates multiple biological effects include decreasing endothelial cell activation,blocking neutrophil extravasation,regulating immune cell function,promoting neutrophil apoptosis and macrophage phagocytosis. Chronic inflammation is a pathogenic factor for diabetes mellitus (DM) and related vascular complications. SPM can promote the extinction of inflammation and reduce the complications of microvascular and macrovascular in DM ,which is expected to become a new therapeutic target for DM and vascular diseases. This article reviews the recent progress of SPM in DM and its vasculopathy.

参考文献/References:

[1].Charlton A,Garzarella J,Jandeleit-Dahm KAM,et al. Oxidative stress and inflammation in renal and cardiovascular complications of diabetes[J].?Biology,2020,10(1):18.
[2].Galicia-Garcia U,Benito-Vicente A,Jebari S,et al. Pathophysiology of type 2 diabetes mellitus[J].?Int J Mol Sci,2020,21(17):6275.
[3].Recchiuti A,Mattoscio D,Isopi E. Roles,actions,and therapeutic potential of specialized pro-resolving lipid mediators for the treatment of inflammation in cystic fibrosis[J].?Front Pharmacol,2019,10:252.
[4].Climax J,Newsome PN,Hamza M,et al. Effects of epeleuton,a novel synthetic second-generation n-3 fatty acid,on non-alcoholic fatty liver disease,triglycerides,glycemic control,and cardiometabolic and inflammatory markers[J]. J Am Heart Assoc,2020,9(16):e016334.
[5].Duan J,Song Y,Zhang X,et al. Effect of ω-3 polyunsaturated fatty acids-derived bioactive lipids on metabolic disorders[J] .?Front Physiol,2021,12:646491.
[6].Perez-Hernandez J,Chiurchiù V,Perruche S,et al. Regulation of T-cell immune responses by pro-resolving lipid mediators[J].?Front Immunol,2021,12:768133.
[7].Serhan CN. Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology[J].?Mol Aspects Med,2017,58:1-11.
[8].Park J,Langmead CJ,Riddy DM. New advances in targeting the resolution of inflammation:implications for specialized pro-resolving mediator GPCR drug discovery[J].?ACS Pharmacol Transl Sci,2020,3(1):88-106.
[9].Souza PR,Marques RM,Gomez EA,et al. Enriched marine oil supplements increase peripheral blood specialized pro-resolving mediators concentrations and reprogram host immune responses:a randomized double-blind placebo-controlled study[J]. Circ Res,2020,126(1):75-90.
[10].de Gaetano M,McEvoy C,Andrews D,et al. Specialized pro-resolving lipid mediators:modulation of diabetes-associated cardio-,reno-,and retino-vascular complications[J].?Front Pharmacol,2018,9:1488.
[11].Beverly JK,Budoff MJ. Atherosclerosis:pathophysiology of insulin resistance,hyperglycemia,hyperlipidemia,and inflammation[J]. J Diabetes,2020,12(2):102-104.
[12].Bays HE,Taub PR,Epstein E,et al. Ten things to know about ten cardiovascular disease risk factors[J].?Am J Prev Cardiol,2021,5:100149.
[13].Brennan EP,Mohan M,McClelland A,et al.Lipoxins protect against inflammation in diabetes-associated atherosclerosis[J].Diabetes,2018,67(12):2657-2667.
[14].Yuan T,Yang T,Chen H,et al. New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis[J]. Redox Biol,2019,20:247-260.
[15].Brennan E,Wang B,McClelland A,et al. Protective effect of let-7 miRNA family in regulating inflammation in diabetes-associated atherosclerosis[J]. Diabetes,2017,66(8):2266-2277.
[16].Fredman G,Tabas I. Boosting inflammation resolution in atherosclerosis:the next frontier for therapy[J]. Am J Pathol,2017,187(6):1211-1221.
[17].Brennan E,Kantharidis P,Cooper ME,et al. Pro-resolving lipid mediators:regulators of inflammation,metabolism and kidney function[J]. Nat Rev Nephrol,2021,17(11):725-739.
[18].Brennan EP,Mohan M,McClelland A,et al. Lipoxins regulate the early growth response-1 network and reverse diabetic kidney disease[J].J Am Soc Nephrol,2018,29(5):1437-1448.
[19].Sifuentes-Franco S,Padilla-Tejeda DE,Carrillo-Ibarra S.?Oxidative stress,apoptosis,and mitochondrial function in diabetic nephropathy[J].?Int J Endocrinol,2018,2018:1875870.
[20].Roh J,Go EJ,Park JW,et al. Resolvins:potent pain inhibiting lipid mediators via transient receptor potential regulation[J].?Front Cell Dev Biol,2020,8:584206.
[21].Perazza LR,Mitchell PL,Lizotte F,et al. Fish oil replacement prevents,while docosahexaenoic acid-derived protectin DX mitigates end-stage-renal-disease in atherosclerotic diabetic mice[J].?FASEB J,2021,35(5):e21559.
[22].Bai Y,Wang J,He Z,et al. Mesenchymal stem cells reverse diabetic nephropathy disease via lipoxin A4 by targeting transforming growth factor β (TGF-β)/smad pathway and pro-inflammatory cytokines [J]. Med Sci Monit,2019,25:3069-3076.
[23].Qiu X,Wang X,Hong P,et al. Retinal blood oxygen saturation and vascular endothelial growth factor-A in early diabetic retinopathy:a protocol for systematic review and meta-analysis[J].?Medicine (Baltimore),2020,99(24):e20562.
[24].Storti F,Pulley J,Kuner P,et al. Circulating biomarkers of inflammation and endothelial activation in diabetic retinopathy[J].?Transl Vis Sci Technol,2021,10(12):8.
[25].Rubsam A,Parikh S,Fort PE. Role of inflammation in diabetic retinopathy[J].?Int J Mol Sci,2018,19(4):942.
[26].Yin Y,Chen F,Wang W,et al.?Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats:possible involvement of NLRP3 inflammasome and NF-kappaB signaling pathway[J].?Mol Vis,2017,23:242-250.
[27].Le YZ,Xu B,Chucair-Elliott AJ,et al. VEGF mediates retinal müller cell viability and neuroprotection through BDNF in diabetes[J]. Biomolecules,2021,11(5):712.
[28].Platania CBM,Maisto R,Trotta MC,et al. Retinal and circulating miRNA expression patterns in diabetic retinopathy:An in silico and in vivo approach[J]. Br J Pharmacol,2019,176(13):2179-2194.
[29].Dobrian AD,Morris MA,Taylor-Fishwick DA,et al. Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications[J].?Pharmacol Ther,2019,195:100-110.
[30].Coppey L,Davidson E,Shevalye H,et al. Progressive loss of corneal nerve fibers and sensitivity in rats modeling obesity and type 2 diabetes is reversible with omega-3 fatty acid intervention:supporting cornea analyses as a marker for peripheral neuropathy and treatment[J].?Diabetes Metab Syndr Obes,2020,13:1367-1384.
[31].Ye D,Fairchild TJ,Vo L,et al. Painful diabetic peripheral neuropathy:role of oxidative stress and central sensitisation[J]. Diabet Med,2022,39(1):e14729.
[32].Sharma A,Mah M,Ritchie RH,et al.The adiponectin signalling pathway - A therapeutic target for the cardiac complications of type 2 diabetes?[J]. Pharmacol Ther,2021,108008.
[33].Wu SH,Chen XQ,Liu B,et al. Efficacy and safety of 15(R/S)-methyl-lipoxin A(4) in topical treatment of infantile eczema[J]. Br J Dermatol,2013,108(1):172-178.
[34].Basil MC,Levy BD. Specialized pro-resolving mediators:endogenous regulators of infection and inflammation[J].?Nat Rev Immunol,2016,16(1):51-67.
[35].Serhan CN,Chiang N,Dalli J. The resolution code of acute inflammation:Novel pro-resolving lipid mediators in resolution[J].?Semin Immunol,2015,27(3):200-215.

更新日期/Last Update: 2022-05-13