[1]陈春宇?黄鸿.磷酸二酯酶1抑制剂ITI-214在心血管疾病中的研究现状及治疗潜力[J].心血管病学进展,2022,(5):440-443.[doi:10.16806/j.cnki.issn.1004-3934.2022.05.014]
 CHEN Chunyu,HUANG Hong,CHEN Jingjing,et al.Research Status and Therapeutic Potential of Phosphodiesterase 1 Inhibitor ITI-214 in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2022,(5):440-443.[doi:10.16806/j.cnki.issn.1004-3934.2022.05.014]
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磷酸二酯酶1抑制剂ITI-214在心血管疾病中的研究现状及治疗潜力()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年5期
页码:
440-443
栏目:
出版日期:
2022-05-25

文章信息/Info

Title:
Research Status and Therapeutic Potential of Phosphodiesterase 1 Inhibitor ITI-214 in Cardiovascular Diseases
作者:
陈春宇?黄鸿
(贵州医科大学附属医院)
Author(s):
CHEN Chunyu1 HUANG Hong2 CHEN Jingjing3 CHEN Lei1
(1.Department of Emergency,The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China; 2.Department of General Ward,The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China; 3.Department of Cardiology,The Affiliated Hospital of Guizhou Medical University,Guiyang 550004,Guizhou,China)
关键词:
磷酸二酯酶1抑制剂ITI-214心血管疾病
Keywords:
Phosphodiesterase 1 inhibitorITI-214Cardiovascular diseases
DOI:
10.16806/j.cnki.issn.1004-3934.2022.05.014
摘要:
作为一种多种潜在疾病的独特治疗靶点,通过对环磷酸腺苷及环磷酸鸟苷信号通路的基本调节在心血管疾病的发生和发展中扮演着重要角色。ITI-214是一种高的1抑制剂ITI-214在心血管疾病中的研究现状及其治疗潜力做简要的介绍。
Abstract:
plays an important role in the occurrence and development of cardiovascular diseases through the basic regulation of cyclic adenosine monophosphate and cyclic guanosine monophosphate signaling pathways. ITI-214 is a highly selective phosphodiesterase 1 inhibitor. In mammalian studies,it has shown a good regulatory effect on heart failure,arrhythmia and aging-related cardiovascular diseases. It also shows the effects of improving vascular function,relieving inflammatory reaction and regulating ion current. These evidences indicate that ITI-214 has great potential in the treatment of cardiovascular diseases. This paper briefly introduces the research status and therapeutic potential of ITI-214 in cardiovascular diseases

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更新日期/Last Update: 2022-06-30