[1]李彤 郭宏.不确定潜能的克隆性造血与心血管疾病的相关研究进展[J].心血管病学进展,2021,(11):961-964.[doi:】10.16806/j.cnki.issn.1004-3934.2021.11.000]
　LI Tong,GUO Hong.The Correlation Between Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2021,(11):961-964.[doi:】10.16806/j.cnki.issn.1004-3934.2021.11.000]
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不确定潜能的克隆性造血与心血管疾病的相关研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年11期
页码:
961-964
栏目:
综述
出版日期:
2021-11-25

文章信息/Info

Title:
The Correlation Between Clonal Hematopoiesis of Indeterminate Potential and Cardiovascular Diseases
文章编号:
202107048
作者:
李彤1 郭宏1; 2
(1.哈尔滨医科大学研究生院,黑龙江 哈尔滨 150000;2

哈尔滨医科大学附属第一医院心内科，黑龙江 哈尔滨

150000)
Author(s):
LI Tong1;  GUO Hong1; 2
(1.Harbin Medical University Graduate SchoolHarbin 150000,Heilongjiang,China; 2.Department of Cardiology,The First Affiliated Hospital of Harbin Medical University,Harbin 150000,Heilongjiang,China)
Keywords:
Clonal hematopoiesis of indeterminate potential; Cardiovascular diseases; Gene mutation
DOI:
】10.16806/j.cnki.issn.1004-3934.2021.11.000
摘要:

传统的危险因素已不能完全预测心血管疾病 （CVD） 的发展 ， 最新研究 表明，造血系统的体细胞突变与 CVD 之间存在以前未被认识到的联系。 炎症反应是 CVD 的主要发病机制之一，而动物模型显示， 不确定潜能 的 克隆 性 造血 （ CHIP ）的相关突变放大了炎症反应，同时 CHIP 患者炎症标志物水平升高，增加 了CVD 风险。随着 第二代测序技术 被广泛应用于临床， CHIP 患者的管理已成为一个迅速兴起的热点， 因此深入探讨 CHIP 致 CVD 的机制有重要临床意义 ，也为今后 寻找有效防治措施 提供了理论基础 。

Abstract:
Traditional risk factors can’t completely predict the development of cardiovascular diseases(CVD). New research shows that there is a previously unrecognized connection between somatic mutation in hematopoietic system and CVD. Inflammatory reaction is one of the main pathogenesis of CVD. Animal models show that the mutations related to clonal hematopoiesis of indeterminate potential (CHIP) amplify the inflammatory reaction,and the level of inflammatory markers in CHIP patients increases,which increases the risk of CVD. With the second generation sequencing ?techniques being widely used in clinic,the management of CHIP patients has become a hot spot. Therefore,in-depth exploration of the mechanism of CHIP-induced CVD has important clinical significance and provides a theoretical basis for finding effective prevention and treatment measures in the future.

参考文献/References:

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更新日期/Last Update: 2021-12-06