[1]陈远洋 王志维.供体巨噬细胞在心脏移植中的研究进展[J].心血管病学进展,2022,(6):514.[doi:10.16806/j.cnki.issn.1004-3934.2022.06.009]
 CHEN Yuanyang,WANG Zhiwei.Donor Macrophages in Heart Transplantation[J].Advances in Cardiovascular Diseases,2022,(6):514.[doi:10.16806/j.cnki.issn.1004-3934.2022.06.009]
点击复制

供体巨噬细胞在心脏移植中的研究进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2022年6期
页码:
514
栏目:
综述
出版日期:
2022-06-25

文章信息/Info

Title:
Donor Macrophages in Heart Transplantation
作者:
陈远洋 王志维
(武汉大学人民医院心血管外科,湖北 武汉 430000)
Author(s):
CHEN YuanyangWANG Zhiwei
(Department?of Cardiovascular Surgery,Renmin Hospital of Wuhan University,Wuhan 430000,HubeiChina)
关键词:
供体巨噬细胞心脏移植免疫耐受缺血再灌注
Keywords:
DonorMacrophageHeart transplantationImmune toleranceIschemia reperfusion
DOI:
10.16806/j.cnki.issn.1004-3934.2022.06.009
摘要:
1960年以来,心脏移植仍是心力衰竭终末期患者的最佳治疗手段,每年可延长成千上万人的寿命及改善其生活质量。免疫抑制剂的使用虽然有效,但由于缺乏特异性,常出现药物副作用,例如增加感染和恶性肿瘤风险。现集中讨论供体巨噬细胞作为新的治疗靶标的可能与优势。供体器官定向疗法能有效提高同种异体移植存活率,同时最大程度地减少整体免疫抑制导致的副作用的损伤。综述内容主要突出不同供体巨噬细胞群体在缺血再灌注损伤和排斥中的作用,包括它们与同种异体浸润受体免疫细胞之间的相互作用以及潜在的治疗方法。更好地了解供体固有免疫如何影响同种异体移植心脏的存活,将为改善心脏移植术后患者的预后提供新的思路。
Abstract:
Since the 1960s,heart transplantation has remained the best treatment for patients with end-stage heart failure,extending the lives and improving the quality of life of thousands of people each year. Immunosuppressant use,although effective,is often associated with side effects such as increased risk of infection and malignancy due to lack of specificity. In this review,we focus on donor macrophages as novel therapeutic targets. Donor organ directed therapy can effectively improve allograft survival and minimize the adverse effects associated with global immunosuppression. The review highlights the role of different donor macrophage populations in ischemia-reperfusion injury and rejection,including their interactions with allograft infiltrating recipient immune cells and potential therapeutic approaches. Ultimately,a better understanding of how donor innate immunity influences allograft heart survival will provide new insights into improving outcomes for patients after heart transplantation

参考文献/References:

[1] Goldstein BA,Thomas L,Zaroff JG,et al. Assessment of heart transplant waitlist time and pre- and post-transplant failure:a mixed methods approach[J]. Epidemiology,2016,27(4):469-476.

[2] Khush KK,Zaroff JG,Nguyen J,et al. National decline in donor heart utilization with regional variability:1995-2010[J]. Am J Transplant,2015,15(3):642-649.

[3]Dick SA,Macklin JA,Nejat S,et al. Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction[J]. Nat Immunol,2019,20(1):29-39.

[4]Bajpai G,Bredemeyer A,Li W,et al. Tissue resident CCR2- and CCR2+ cardiac macrophages differentially orchestrate monocyte recruitment and fate specification following myocardial injury [J]. Circ Res,2019,124(2):263-278.

[5]Chiu S,Bharat A. Role of monocytes and macrophages in regulating immune response following lung transplantation[J]. Curr Opin Organ Transplant,2016,21(3):239-245.

[6]Hsiao HM,Fernandez R,Tanaka S,et al. Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1β[J]. J Clin Invest,2018,128(7):2833-2847.

[7]Misharin AV,Morales-Nebreda L,Reyfman PA,et al. Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span[J]. J Exp Med,2017,214(8):2387-2404.

[8]Nayak DK,Zhou F,Xu M,et al. Long-term persistence of donor alveolar macrophages in human lung transplant recipients that influences donor-specific immune responses[J]. Am J Transplant,2016,16(8):2300-2311.

[9]Eguíluz-Gracia I,Schultz HH,Sikkeland LI,et al. Long-term persistence of human donor alveolar macrophages in lung transplant recipients[J]. Thorax,2016,71(11):1006-1011.

[10]Nicoara A,Ruffin D,Cooter M,et al. Primary graft dysfunction after heart transplantation:incidence,trends,and associated risk factors[J]. Am J Transplant,2018,18(6):1461-1470.

[11]Dhuriya YK,Sharma D. Necroptosis:a regulated inflammatory mode of cell death[J]. J Neuroinflammation,2018,15(1):199.

[12]van den Bosch TP,Caliskan K,Kraaij MD,et al. CD16+ monocytes and skewed macrophage polarization toward M2 type hallmark heart transplant acute cellular rejection[J]. Front Immunol,2017,8:346.

[13]Liu Y,Kloc M,Li XC. Macrophages as effectors of acute and chronic allograft injury[J]. Curr Transplant Rep,2016,3(4):303-312.

[14]Loupy A,Hidalgo L,Duong JP,et al. Response by Loupy et al to letters regarding article,"gene expression profiling for the identification and classification of antibody-mediated heart rejection"[J]. Circulation,2017,136(7):698-699.

[15]Pabois A,Pagie S,Gerard N,et al. Notch signaling mediates crosstalk between endothelial cells and macrophages via Dll4 and IL6 in cardiac microvascular inflammation[J]. Biochem Pharmacol,2016,104:95-107.

[16]Braza MS,van Leent MMT,Lameijer M,et al. Inhibiting inflammation with myeloid cellspecific nanobiologics promotes organ transplant acceptance[J]. Immunity,2018,49(5):819-828e6.

[17]Xie Y,Tolmeijer S,Oskam JM,et al. Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration[J]. Dis Model Mech,2019,12(5):dmm037887.

[18]Braza MS,conde P,Garcia M,et al. Neutrophil derived CSF1 induces macrophage polarization and promotes transplantation tolerance[J]. Am J Transplant,2018,18(5):1247-1255.

[19]Zhao Y,Chen S,Lan P,et al. Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model[J]. Am J Transplant,2018,18(3):604-616.

[20]Salehi S,Reed EF. The divergent roles of macrophages in solid organ transplantation[J]. Curr Opin Organ Transplant,2015,20(4):446-453.

[21]de Graav GN,Bergan S,Baan CC,et al. Therapeutic drug monitoring of belatacept in kidney transplantation[J]. Ther Drug Monit,2015,37(5):560-567.

[22]Wu YL,Ye Q,Eytan DF,et al. Magnetic resonance imaging investigation of macrophages in acute cardiac allograft rejection after heart transplantation[J]. Circ Cardiovasc Imaging,2013,6(6):965-973.

[23]Pajaro OE,Jaroszewski DE,Scott RL,et al. Antibody-mediated rejection in heart transplantation:case presentation with a review of current international guidelines[J]. J Transplant,2011,2011:351950.

[24]Sica A,Mantovani A. Macrophage plasticity and polarization:in vivo veritas[J]. J Clin Invest,2012,122(3):787-795.

相似文献/References:

[1]张伟 黄从新.巨噬细胞与心血管稳态和疾病[J].心血管病学进展,2019,(9):1241.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.014]
 ZHANG Wei,HUANG Congxin.Macrophages are Associated with Cardiovascular Homeostasis and Diseases[J].Advances in Cardiovascular Diseases,2019,(6):1241.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.014]
[2]李一凡 张智伟.巨噬细胞相关的外泌体在心血管疾病中的作用研究进展[J].心血管病学进展,2020,(8):839.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.014]
 LI Yifan,ZHANG Zhiwei.Role of Macrophage-Related Exosomes in Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2020,(6):839.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.014]
[3]付韫韬 赵庆彦?/html>.巨噬细胞调控离子通道致心律失常研究的最新进展[J].心血管病学进展,2022,(2):100.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.002]
 FU Yuntao ZHAO Qingyan.Macrophages Regulating Ion Channels to Induce Arrhythmia[J].Advances in Cardiovascular Diseases,2022,(6):100.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.002]
[4]陈乾 秦铭 徐志云.单核/巨噬细胞与主动脉瓣钙化研究进展[J].心血管病学进展,2022,(10):898.[doi:10.16806/j.cnki.issn.1004-3934.2022.10.008]
 CHEN Qian,QIN Ming,XU Zhiyun.Aortic Valve Calcification Caused by Mononuclear Phagocyte System[J].Advances in Cardiovascular Diseases,2022,(6):898.[doi:10.16806/j.cnki.issn.1004-3934.2022.10.008]
[5]王朝阳 赵丽娜 田师鹏 陈淑霞 谷剑.炎症治疗在动脉粥样硬化中的研究进展[J].心血管病学进展,2023,(6):519.[doi:10.16806/j.cnki.issn.1004-3934.2023.06.009]
 WANG Zhaoyang,ZHAO Lina,TIAN Shipeng,et al.Advances in the Treatment of Inflammation in Atherosclerosis[J].Advances in Cardiovascular Diseases,2023,(6):519.[doi:10.16806/j.cnki.issn.1004-3934.2023.06.009]
[6]黄爱宝??少衡.巨噬细胞治疗缺血心肌的研究进展[J].心血管病学进展,2024,(6):543.[doi:10.16806/j.cnki.issn.1004-3934.2024.06.015]
 HUANG Aibao,ZHANG Shaoheng?/html>.Research progress in Macrophage Therapy for?schemic Myocardium[J].Advances in Cardiovascular Diseases,2024,(6):543.[doi:10.16806/j.cnki.issn.1004-3934.2024.06.015]

更新日期/Last Update: 2022-08-05