[1]邱泽阳 季爽 陈丽红.生物钟调控心肌细胞死亡的研究进展[J].心血管病学进展,2021,(11):973-977.[doi:10.16806/j.cnki.issn.1004-3934.2021.11.000]
 QIU ZeyangJI ShuangCHEN Lihong.Circadian Clock Regulating Myocardial Cell Death[J].Advances in Cardiovascular Diseases,2021,(11):973-977.[doi:10.16806/j.cnki.issn.1004-3934.2021.11.000]
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生物钟调控心肌细胞死亡的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年11期
页码:
973-977
栏目:
综述
出版日期:
2021-11-25

文章信息/Info

Title:
Circadian Clock Regulating Myocardial Cell Death
文章编号:
202106006
作者:
邱泽阳1 季爽 12 陈丽红 12
(1.大连医科大学,辽宁 大连 116044;2.大连医科大学医学科学研究院,辽宁 大连 116044)
Author(s):
QIU Zeyang1JI Shuang12CHEN Lihong12
(1. Dalian Medical University,Dalian 116044,Liaoning,China2.Advanced Institute for Medical Sciences,Dalian Medical University,Dalian 116044,Liaoning,China)
关键词:
昼夜节律细胞死亡心血管疾病
Keywords:
Circadian clockCell deathCardiovascular diseases
DOI:
10.16806/j.cnki.issn.1004-3934.2021.11.000
摘要:
生物钟在调控心血管生理功能和疾病发生和发展的过程中发挥重要作用。心肌细胞死亡是心肌缺血再灌注损伤的主要病理机制,是导致缺血后心室重塑和心功能不全的重要环节。近年来大量研究表明,生物钟不仅参与心肌细胞死亡的过程,同时会明显影响心脏对药物的耐受性和敏感性。因此,深入了解生物钟调节心肌细胞死亡,包括凋亡、坏死、自噬、铁死亡及焦亡等过程的分子机制,对优化心血管疾病的治疗措施和效果具有重要的临床意义。
Abstract:
Circadian clock plays significant roles in regulating cardiovascular physiological function and disease development. Myocardial cell death is the main pathological mechanism of myocardial ischemia reperfusion injury and an important link leading to ventricular remodeling and cardiac dysfunction after ischemia. More and more evidence suggests that circadian clock was not only involved in the process of myocardial cell death but also significantly affects the heart’s tolerance and sensitivity to drugs. Thus,understanding the role of circadian clock in cardiac cell death,including apoptosis,necrosis,autophagy,ferroptosis,pyroptosis and so on,may have crucial clinical significance for optimizing the treatment strategies for cardiovascular diseases.

参考文献/References:

[1] Durgan DJ,Young ME. The cardiomyocyte circadian clock:emerging roles in health and disease[J]. Circ Res,2010,106(4):647-658.

[2] Carden DL,Granger DN. Pathophysiology of ischaemia-reperfusion injury[J]. J Pathol,2000,190(3):255-266.

[3] Mishra PK,Adameova A,Hill JA,et al. Guidelines for evaluating myocardial cell death[J]. Am J Physiol Heart Circ Physiol,2019,317(5):H891-H922.

[4] Zhang R,Lahens NF,Ballance HI,et al. A circadian gene expression atlas in mammals:implications for biology and medicine[J]. Proc Natl Acad Sci U S A,2014,111(45):16219-16224.

[5] Thosar SS,Butler MP,Shea SA. Role of the circadian system in cardiovascular disease[J]. J Clin Invest,2018,128(6):2157-2167.

[6] Lowrey PL,Takahashi JS. Genetics of circadian rhythms in Mammalian model organisms[J]. Adv Genet,2011,74:175-230.

[7] Martino T,Arab S,Straume M,et al. Day/night rhythms in gene expression of the normal murine heart[J]. J Mol Med(Berl),2004,82(4):256-264.

[8] Kung TA,Egbejimi O,Cui J,et al. Rapid attenuation of circadian clock gene oscillations in the rat heart following ischemia-reperfusion[J]. J Mol Cell Cardiol,2007,43(6):744-753.

[9] Bonney S,Kominsky D,Brodsky K,et al. Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart[J]. PLoS One,2013,8(8):e71493.

[10] Oyama Y,Bartman CM,Gile J,et al. The circadian PER2 enhancer nobiletin reverses the deleterious effects of midazolam in myocardial ischemia and reperfusion injury[J]. Curr Pharm Des,2018,24(28):3376-3383.

[11] Reitz CJ,Alibhai FJ,Khatua TN,et al. SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome[J]. Commun Biol,2019,2:353.

[12] Ghorbel MT,Coulson JM,Murphy D. Cross-talk between hypoxic and circadian pathways:cooperative roles for hypoxia-inducible factor 1alpha and CLOCK in transcriptional activation of the vasopressin gene[J]. Mol Cell Neurosci,2003,22(3):396-404.

[13] Wu Y,Tang D,Liu N,et al. Reciprocal regulation between the circadian clock and hypoxia signaling at the genome level in mammals[J]. Cell Metab,2017,25(1):73-85.

[14] Keller M,Mazuch J,Abraham U,et al. A circadian clock in macrophages controls inflammatory immune responses[J]. Proc Natl Acad Sci U S A,2009,106(50):21407-21412.

[15] Lee JH,Sancar A. Regulation of apoptosis by the circadian clock through NF-kappaB signaling[J]. Proc Natl Acad Sci U S A,2011,108(29):12036-12041.

[16] Mullenders J,Fabius AW,Madiredjo M,et al. A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway[J]. PLoS One,2009,4(3):e4798.

[17] Wang EY,Gang H,Aviv Y,et al. p53 mediates autophagy and cell death by a mechanism contingent on Bnip3[J]. Hypertension,2013,62(1):70-77.

[18] Dhingra R,Margulets V,Chowdhury SR,et al. Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling[J]. Proc Natl Acad Sci U S A,2014,111(51):E5537-E5544.

[19] Li E,Li X,Huang J,et al. BMAL1 regulates mitochondrial fission and mitophagy through mitochondrial protein BNIP3 and is critical in the development of dilated cardiomyopathy[J]. Protein Cell,2020,11(9):661-679.

[20] Pacher P,Szabo C. Role of poly(ADP-ribose) polymerase 1(PARP-1) in cardiovascular diseases:the therapeutic potential of PARP inhibitors[J]. Cardiovasc Drug Rev,2007,25(3):235-260.

[21] Oerlemans MI,Liu J,Arslan F,et al. Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo[J]. Basic Res Cardiol,2012,107(4):270.

[22] Ying L,Benjanuwattra J,Chattipakorn SC,et al. The role of RIPK3-regulated cell death pathways and necroptosis in the pathogenesis of cardiac ischaemia-reperfusion injury[J]. Acta Physiol(Oxf),2021,231(2):e13541.

[23] McDonald MJ,Rosbash M. Microarray analysis and organization of circadian gene expression in Drosophila[J]. Cell,2001,107(5):567-578.

[24] Pfeifer U,Strauss P. Autophagic vacuoles in heart muscle and liver. A comparative morphometric study including circadian variations in meal-fed rats[J]. J Mol Cell Cardiol,1981,13(1):37-49.

[25] Rothermel BA,Hill JA. Myocyte autophagy in heart disease:friend or foe?[J]. Autophagy,2007,3(6):632-634.

[26] Sciarretta S,Hariharan N,Monden Y,et al. Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart?[J]. Pediatr Cardiol,2011,32(3):275-281.

[27] Wedel A,Ziegler-Heitbrock HW. The C/EBP family of transcription factors[J]. Immunobiology,1995,193(2-4):171-185.

[28] Lamia KA,Sachdeva UM,DiTacchio L,et al. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation[J]. Science,2009,326(5951):437-440.

[29] Egan DF,Shackelford DB,Mihaylova MM,et al. Phosphorylation of ULK1(hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy[J]. Science,2011,331(6016):456-461.

[30] Ishii T,Warabi E,Mann GE. Circadian control of BDNF-mediated Nrf2 activation in astrocytes protects dopaminergic neurons from ferroptosis[J]. Free Radic Biol Med,2019,133:169-178.

[31] Liu J,Yang M,Kang R,et al. Autophagic degradation of the circadian clock regulator promotes ferroptosis[J]. Autophagy,2019,15(11):2033-2035.

[32] Gao M,Monian P,Quadri N,et al. Glutaminolysis and transferrin regulate ferroptosis[J]. Mol Cell,2015,59(2):298-308.

[33] Li W,Feng G,Gauthier JM,et al. Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation[J]. J Clin Invest,2019,129(6):2293-2304.

[34] Fang X,Wang H,Han D,et al. Ferroptosis as a target for protection against cardiomyopathy[J]. Proc Natl Acad Sci U S A,2019,116(7):2672-2680.

[35] Ge X,Li W,Huang S,et al. The pathological role of NLRs and AIM2 inflammasome-mediated pyroptosis in damaged blood-brain barrier after traumatic brain injury[J]. Brain Res,2018,1697:10-20.

[36] Lacey CA,Mitchell WJ,Dadelahi AS,et al. Caspase-1 and caspase-11 mediate pyroptosis,inflammation,and control of brucella joint infection[J]. Infect Immun,2018,86(9):e00361-18.

[37] Afonina IS,Zhong Z,Karin M,et al. Limiting inflammation—The negative regulation of NF-κB and the NLRP3 inflammasome[J]. Nat Immunol,2017,18(8):861-869.

[38] Man SM,Karki R,Kanneganti TD. Molecular mechanisms and functions of pyroptosis,inflammatory caspases and inflammasomes in infectious diseases[J]. Immunol Rev,2017,277(1):61-75.

[39] Kayagaki N,Warming S,Lamkanfi M,et al. Non-canonical inflammasome activation targets caspase-11[J]. Nature,2011,479(7371):117-121.

[40] Kawaguchi M,Takahashi M,Hata T,et al. Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia/reperfusion injury[J]. Circulation,2011,123(6):594-604.

[41] Pan J,Han L,Guo J,et al. AIM2 accelerates the atherosclerotic plaque progressions in ApoE-/- mice[J]. Biochem Biophys Res Commun,2018,498(3):487-494.

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更新日期/Last Update: 2021-12-06