[1]王敏 袁博 张一凡 庞咪 潘金.外周血单个核细胞中circTCF25表达水平在肺源性心脏病患者诊断及预后中的应用[J].心血管病学进展,2021,(10):957.[doi:10.16806/j.cnki.issn.1004-3934.2021.10.022]
　WANG Min,YUAN Bo,ZHANG Yifan,et al.pplication of circTCF25 in Peripheral Blood Mononuclear Cells on Diagnosis and Prognosis Evaluation of Cor Pulmonale?/html>[J].Advances in Cardiovascular Diseases,2021,(10):957.[doi:10.16806/j.cnki.issn.1004-3934.2021.10.022]
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外周血单个核细胞中circTCF25表达水平在肺源性心脏病患者诊断及预后中的应用()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年10期
页码:
957
栏目:
论著
出版日期:
2021-10-25

文章信息/Info

Title:
pplication of circTCF25 in Peripheral Blood Mononuclear Cells on Diagnosis and Prognosis Evaluation of Cor Pulmonale?/html>
作者:
王敏 袁博 张一凡 庞咪 潘金
(西安交大医学院附属市九院(西安市第九医院)
Author(s):
WANG Min; YUAN Bo; ZHANG Yifan; PANG Mi; PAN Jin?/html>
?Department of Cardiology,Ninth Affiliated Hospital of Xi’an Jiaotong University Medical College,Xi’an 710054, ShaanxiChina)
关键词:
肺源性心脏病; 环状RNA; circTCF25; 诊断; 预后
Keywords:
Cor pulmonale;  Circular RNA;  CircTCF25;  Diagnosis;  Prognosis
DOI:
10.16806/j.cnki.issn.1004-3934.2021.10.022
摘要:
目的探讨外周血单个核细胞（PBMCs）中环状RNA circTCF25在肺源性心脏病（CP）患者诊断及预后评估中的应用价值。方法选取2016年11月至2018年11月我院收治的CP患者52例（CP组），另选取同期性别、年龄匹配的健康体检者30例（对照组）作为研究对象，采用实时荧光定量聚合酶链反应（RT-PCR）检测两组PBMCs中circTCF25表达水平；采用Pearson相关法对CP组circTCF25水平与动脉血氧分压（PaO2）、脑钠肽（BNP）进行相关性分析；应用受试者工作特征（ROC）曲线评价circTCF25在CP诊断和预后评估中的应用价值。结果CP组PaO2水平显著低于对照组（P＜0.05），BNP水平显著低于对照组（P＜0.05）；CP组PMBCs中circTCF25水平显著高于对照组（P＜0.05）；Pearson相关分析结果显示circTCF25表达水平与PaO2呈显著负相关（r=0.633，P＜0.05），与BNP水平呈显著正相关（r=0.528，P＜0.05）；ROC曲线分析结果显示，circTCF25诊断CP的最佳截值为1.37，ROC曲线下面积（AUC）为0.834（95% CI 0.734~0.908）；circTCF25预测CP患者预后不良的最佳截值为1.74，预测的AUC为0.722（95% CI 0.636~0.798）。结论PBMCs中circTCF25表达水平在CP患者明显上调，其对CP诊断和预后评估具有较好的应用价值。
Abstract:
ObjectiveTo explore the application value of circular RNA TCF25 (circTCF25) in peripheral blood mononuclear cells (PBMCs) on diagnosis and prognosis evaluation of cor pulmonale (CP). Methods52 patients with CP ( CP group) and 30 healthy controls (control group) with matched gender and age admitted to ourhospital from November,2016 to November,2018 were enrolled as research objects. The expression level of circTCF25 in PBMCs w as detected by RT-PCR. Correlations ofcircTCF25 witharterial oxygen partial pressure (PaO 2) and brain natriuretic peptide (BNP) in CP group w ere analyzed with Pearson correlation analysis. The application value of circTCF25 on diagnosis and prognosis evaluation of CP was determined by receiver operating characteristic (ROC) curve. ResultsCompared with control group,PaO2 and BNP level in CP group were both decreased ( P＜0.05),and circTCF25 level in PMBCs was increased ( P＜0.05). Pearson correlation analysis showed circTCF25 level was negatively correlated with PaO2 ( r=0.633,P＜0.05),andpositively correlated with BNP level (r=0.528,P＜0.05). ROC curves analysis showed the best cut -off value of circTCF25 for diagnosis with CP was 1.37 ,withthe area under ROC curve (AUC) of 0.834 (95%CI0.734～0.908).The best cut-off value and AUC of circTCF25 for predicting poor prognosis of CPwere 1.74 a nd 0.722 (95%CI 0.636～0.798),respectively. ConclusionThe expression level of circTCF25 in PBMCs is distinctly up-regulated in CP patients ,which may be of good application value on diagnosis and prognosis evaluation for CP

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更新日期/Last Update: 2021-12-02