[1]贾圣琪 李拥军 田丁元.睡眠高血压治疗的临床意义[J].心血管病学进展,2021,(10):916.[doi:10.16806/j.cnki.issn.1004-3934.2021.10.013]
　JIA ShengqiLI YongjunTIAN Dingyuan.The Clinical Significance of Bedtime Hypertension Treatment[J].Advances in Cardiovascular Diseases,2021,(10):916.[doi:10.16806/j.cnki.issn.1004-3934.2021.10.013]
点击复制

睡眠高血压治疗的临床意义()
分享到：

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年10期
页码:
916
栏目:
综述
出版日期:
2021-10-25

文章信息/Info

Title:
The Clinical Significance of Bedtime Hypertension Treatment
作者:
贾圣琪1 李拥军1 田丁元2
(1.河北医科大学第二医院,河北 石家庄 050004;2.天津医科大学朱宪彝纪念医院,天津300134)
Author(s):
JIA Shengqi1LI Yongjun1TIAN Dingyuan2
(1.The Second Affiliated Hospital of Hebei Medical UniversityShijiazhuang 050004,Hebei,China2.Zhu Xian Yi Memorial Hospital of Tianjin Medical UniversityTianjin 300134,China)
关键词:
睡眠高血压治疗; 睡眠血压; 动态血压监测; 心血管疾病
Keywords:
Bedtime hypertension treatment ; Asleep blood pressure; Ambulatory blood pressure monitoring; Cardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2021.10.013
摘要:
随着动态血压监测的普及，睡眠血压的重要性被日益重视。近20余年来，HOPE研究、Syst-Eur研究、MAPEC研究以及Hygia研究等均表明：相比以往常用的日间血压、办公室血压以及随机血压，睡眠血压对于心血管疾病的发病率及死亡率具有更加重要的意义，是更为有效的预后标志。这些证据提示应更加关注睡眠期的高血压控制。尽管睡眠高血压治疗可有效改善睡眠血压，但其背后有很多潜在问题尚存在争议，尤其对于2型糖尿病、慢性肾脏疾病、睡眠呼吸暂停综合征等患者。现就目前睡眠高血压治疗的研究进展和临床意义进行综述。
Abstract:
With the popularity of ambulatory blood pressure monitoring,more and more attention was paid to asleep blood pressure. In the past 20 years,the HOPE study,the Syst-Eur trial,the MAPEC study and the Hygia chronotherapy trial all showed that the asleep blood pressure is more significant for the morbidity and mortality of cardiovascular diseases and is a more effective prognostic marker compared with the common daytime blood pressure,the office blood pressure and the randomized clinical blood pressure. These evidences suggest that we should pay more attention to the clinical significance of hypertension control during sleep. Although the bedtime hypertension treatment can improve the asleep blood pressure effectively,there are still many potential problems behind it,especially for patients with type 2 diabetes,chronic kidney disease,sleep apnea syndrome and so on. This article reviews the research progress and clinical significance of bedtime hypertension treatment

参考文献/References:

[1].Hermida RC. Ambulatory blood pressure monitoring in the prediction of cardiovascular events and effects of chronotherapy:rationale and design of the MAPEC study[J]. Chronobiol Int,2007,24(4):749-775.
[2].Kario K,Hoshide S,Mizuno H,et al. Nighttime Blood Pressure Phenotype and Cardiovascular Prognosis:Practitioner-Based Nationwide JAMP Study[J]. Circulation,2020,142(19):1810-1820.
[3].Pickering TG. Should we be evaluating blood pressure dipping status in clinical practice?[J]. J Clin Hypertens(Greenwich),2005,7(3):178-182.
[4].Pickering TG,Hall JE,Appel LJ,et al. Recommendations for blood pressure measurement in humans and experimental animals:part 1:blood pressure measurement in humans:a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research[J]. Circulation,2005,111(5):697-716.
[5].Svensson P,de Faire U,Sleight P,et al. Comparative effects of ramipril on ambulatory and office blood pressures:a HOPE Substudy[J]. Hypertension,2001,38(6):E28-E32.
[6].Staessen JA,Fagard R,Thijs L,et al. Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators[J]. Lancet,1997,350(9080):757-764.
[7].Amery A,Birkenh?ger W,Bulpitt CJ,et al. Syst-Eur. A multicentre trial on the treatment of isolated systolic hypertension in the elderly:objectives,protocol,and organization[J]. Aging (Milano),1991,3(3):287-302.
[8].Hermida RC,Ayala DE,Mojón A,et al. Influence of circadian time of hypertension treatment on cardiovascular risk:results of the MAPEC study[J]. Chronobiol Int,2010,27(8):1629-1651.
[9].Portaluppi F,Smolensky MH. Perspectives on the chronotherapy of hypertension based on the results of the MAPEC study[J]. Chronobiol Int,2010,27(8):1652-1667.
[10].Hermida RC,Crespo JJ,Domínguez-Sardi?a M,et al. Bedtime hypertension treatment improves cardiovascular risk reduction:the Hygia Chronotherapy Trial[J].?Eur Heart J,2020,41(48):4565-4576.
[11].Hermida RC,Crespo JJ,Otero A,et al. Asleep blood pressure:significant prognostic marker of vascular risk and therapeutic target for prevention[J]. Eur Heart J,2018,39(47):4159-4171.
[12].Hermida RC,Ayala DE,Mojón A,et al. Sleep-time ambulatory BP is an independent prognostic marker of CKD[J]. J Am Soc Nephrol,2017,28(9):2802-2811.
[13].Hermida RC,Smolensky MH,Ayala DE,et al. Abnormalities in chronic kidney disease of ambulatory blood pressure 24h patterning and normalization by bedtime hypertension chronotherapy[J]. Nephrol Dial Transplant,2014,29(6):1160-1167.
[14].Minutolo R,Gabbai FB,Borrelli S,et al. Changing the timing of antihypertensive therapy to reduce nocturnal blood pressure in CKD:an 8-week uncontrolled trial[J]. Am J Kidney Dis,2007,50(6):908-917.
[15].Wang C,Zhang J,Liu X,et al. Effect of valsartan with bedtime dosing on chronic kidney disease patients with nondipping blood pressure pattern[J]. J Clin Hypertens (Greenwich),2013,15(1):48-54.
[16].Hermida RC,Ayala DE,Mojón A,et al. Bedtime ingestion of hypertension medications reduces the risk of new-onset type 2 diabetes:a randomised controlled trial[J]. Diabetologia,2016,59(2):255-265.
[17].Moyá A,Crespo JJ,Ayala DE,et al. Effects of time-of-day of hypertension treatment on ambulatory blood pressure and clinical characteristics of patients with type 2 diabetes[J]. Chronobiol Int,2013,30(1-2):116-131.
[18].Hermida RC,Ayala DE,Mojón A,et al. Influence of time of day of blood pressure-lowering treatment on cardiovascular risk in hypertensive patients with type 2 diabetes[J]. Diabetes Care,2011,34(6):1270-1276.
[19].Crinion SJ,Ryan S,McNicholas WT. Obstructive sleep apnoea as a cause of nocturnal nondipping blood pressure:recent evidence regarding clinical importance and underlying mechanisms[J]. Eur Respir J,2017,49(1):1601818.
[20].Cuspidi C,Tadic M,Sala C,et al. Blood pressure non-dipping and obstructive sleep apnea syndrome:a meta-analysis[J].J Clin Med,2019,8(9):1367.
[21].Serinel Y,Yee BJ,Grunstein RR,et al. Chronotherapy for hypertension in obstructive sleep apnoea (CHOSA):a randomised,double-blind,placebo-controlled crossover trial[J]. Thorax,2017,72(6):550-558.
[22].Bowe A,Grünig M,Schubert J,et al. Circadian variation in arterial blood pressure and glaucomatous optic neuropathy--a systematic review and meta-analysis[J]. Am J Hypertens,2015,28(9):1077-1082.
[23].Pillunat KR,Spoerl E,Jasper C,et al. Nocturnal blood pressure in primary open-angle glaucoma[J]. Acta Ophthalmol,2015,93(8):e621-e626.
[24].Sánchez-Sánchez C,López-Caballero C,Contreras I,et al. Is bedtime treatment appropriate for all hypertensive patients?[J]. Eur Heart J,2020,41(16):1604.
[25].Kreutz R,Kjeldsen SE,Burnier M,et al. Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project[J].?Blood Press,2020,29(3):135-136.
[26].Machado AP. Blood pressure medication should be routinely dosed at bedtime. An internist’s critical appraisal of the editorial by Rainhold Kreutz et al. (2020). Blood pressure medication should not be routinely dosed at bedtime. We must disregard the data from the HYGIA project. Blood Pressure [J]. Chronobiol Int,2020,37(5):767-770.

更新日期/Last Update: 2021-12-02