[1]李佳珊 关秀茹.ABCA1:调控胆固醇逆向转运与炎症激活之间关系的研究新进展[J].心血管病学进展,2021,(7):649-652.[doi:10.16806/j.cnki.issn.1004-3934.2021.07.018]
 LI Jiashan,GUAN Xiuru.ABCA1: New Progress in Regulating the Relationship Between Cholesterol Reverse Transport and Inflammation Activation[J].Advances in Cardiovascular Diseases,2021,(7):649-652.[doi:10.16806/j.cnki.issn.1004-3934.2021.07.018]
点击复制

ABCA1:调控胆固醇逆向转运与炎症激活之间关系的研究新进展()
分享到:

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年7期
页码:
649-652
栏目:
出版日期:
2021-07-25

文章信息/Info

Title:
ABCA1: New Progress in Regulating the Relationship Between Cholesterol Reverse Transport and Inflammation Activation
作者:
李佳珊1 关秀茹12
(1.哈尔滨医科大学附属第一医院,黑龙江 哈尔滨 150001;2.哈尔滨医科大学附属第一医院检验科,黑龙江 哈尔滨 150001)
Author(s):
LI Jiashan1 GUAN Xiuru12
?1.The First Affiliated Hospital of Harbin Medical University, Harbin 150001,Heilongjiang,China; 2. Laboratory Department,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China )
关键词:
ABCA1胆固醇转运炎症动脉粥样硬化
Keywords:
ATP-binding cassette transporter A1Reverse cholesterol transportInflammationAtherosclerosis
DOI:
10.16806/j.cnki.issn.1004-3934.2021.07.018
摘要:
过量胆固醇蓄积和炎症激活是动脉粥样硬化(AS)发展过程中的两个主要病理过程。据研究报道三磷酸腺苷结合盒转运体(ABCA1)能转运细胞内的胆固醇至载脂蛋白A-I,形成高密度脂蛋白前体,使过多的胆固醇转运至肝脏代谢后重新利用,或随排泄物排出体外,减少泡沫细胞的形成,抑制AS的发生和发展。目前越来越多的研究发现ABCA1还能调控炎症反应或激活炎症小体,意味着在胆固醇代谢与炎症之间有密切的联系,但具体机制还未阐明。现综述ABCA1调控的胆固醇逆向转运与炎症激活之间关系的最新研究进展,突出ABCA1在AS整个病理过程中举足轻重的作用。以ABCA1为切入点,将为临床上预防和治疗AS提供新的靶点。
Abstract:
Excessive cholesterol deposition and inflammation activation are the two main pathological processes in the development of atherosclerosis (AS). It has been reported that ATP-binding cassette transporter A1(ABCA1) can transport intracellular cholesterol to apolipoprotein A-I to produce high-density lipoprotein precursor, so that excessive cholesterol can be transported to the liver for metabolism,reuse or excretion in vitro,reduc ing the formation of foam cells,and inhibit ing the occurrence and development of A S. Currently,more and more studies have found that ABCA1 can regulate inflammatory reaction or activate inflamma some,indicating a certain close relationship between cholesterol metabolism and inflammation,but the specific mechanism is still unclear. This paper reviews the latest research progress on the relationship between ABCA1 regulated cholesterol reverse transport and inflammatory activation,highlighting the pivotal role of ABCA1 in the whole pathological process of AS. Taking ABCA1 as the entry point will provide new targets for clinical prevention and treatment of AS

参考文献/References:

[1] 官宝怡,赵福海. 高密度脂蛋白胆固醇与心血管风险研究进展[J]. 心血管病学进展, 2019, 40(3):317-320.

[2] Qian H,Zhao X,Cao P,et al. Structure of the human lipid exporter ABCA1[J]. Cell,2017,169(7):1228-1239.e10.

[3] Dean M,Rzhetsky A,Allikmets R. The human ATP-binding cassette(ABC) transporter superfamily[J]. Genome Res,2001,11(7):1156-1166.

[4] 韩耀霞,张强,梁斌,等. ABCA1在冠心病及其发病机制中的研究新进展[J]. 中国动脉硬化杂志,2015,23(4):417-421.

[5] Biemans-Oldehinkel E,Doeven MK,Poolman B. ABC transporter architecture and regulatory roles of accessory domains[J]. FEBS Lett,2006,580(4):1023-1035.

[6] Ordovas JM. ABC1:the gene for Tangier disease and beyond[J]. Nutr Rev,2000,58(3 Pt 1):76-79.

[7] Oram JF,Heinecke JW. ATP-binding cassette transporter A1:a cell cholesterol exporter that protects against cardiovascular disease[J]. Physiol Rev,2005,85(4):1343-1372.

[8] Shen W,Anwaier G,Cao Y,et al. Atheroprotective mechanisms of tilianin by inhibiting inflammation through down-regulating NF- kB pathway and foam cells formation[J]. Front Physiol,2019,10:825.

[9] Ou X,Gao JH,He LH,et al. Angiopoietin-1 aggravates atherosclerosis by inhibiting cholesterol efflux and promoting inflammatory response[J]. Biochim Biophys Acta Mol Cell Biol Lipids,2020,1865(2):158535.

[10] Zhang CJ,Zhu N,Liu Z,et al. Wnt5a/Ror2 pathway contributes to the regulation of cholesterol homeostasis and inflammatory response in atherosclerosis[J]. Biochim Biophys Acta Mol Cell Biol Lipids,2020,1865(2):158547.

[11] Wacker BK,Dronadula N,Bi L,et al. Apo A-I(apolipoprotein A-I) vascular gene therapy provides durable protection against atherosclerosis in hyperlipidemic rabbits[J]. Arterioscler Thromb Vasc Biol,2018,38(1):206-217.

[12] Wacker BK,Dronadula N,Zhang J,et al. Local vascular gene therapy with apolipoprotein A-I to promote regression of atherosclerosis[J]. Arterioscler Thromb Vasc Biol,2017,37(2):316-327.

[13] Vaisman BL,Demosky SJ,Stonik JA,et al. Endothelial expression of human ABCA1 in mice increases plasma HDL cholesterol and reduces diet-induced atherosclerosis[J]. J Lipid Res,2012,53(1):158-167.

[14] Stamatikos A,Dronadula N,Ng P,et al. ABCA1 overexpression in endothelial cells in vitro enhances apoAI-mediated cholesterol efflux and decreases inflammation[J]. Hum Gene Ther,2019,30(2):236-248.

[15] Tang C,Houston BA,Storey C,et al. Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages[J]. J Lipid Res,2016,57(5):848-857.

[16] Sonett J,Goldklang M,Sklepkiewicz P,et al. A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure[J]. FASEB J,2018,32(12):fj201701381.

[17] Zhang Z,Zhai L,Lu J,et al. Shen-Hong-Tong-Luo formula attenuates macrophage inflammation and lipid accumulation through the activation of the PPAR-γ/LXR-α/ABCA1 pathway[J]. Oxid Med Cell Longev,2020,2020:3426925.

[18] Castiglioni S,Monti M,Arnaboldi L,et al. ABCA1 and HDL3 are required to modulate smooth muscle cells phenotypic switch after cholesterol loading[J]. Atherosclerosis,2017,266:8-15.

[19] Gu HF,Li N,Xu ZQ,et al. Chronic unpredictable mild stress promotes atherosclerosis via HMGB1/TLR4-Mediated downregulation of PPARgamma/LXRalpha/ABCA1 in ApoE(-/-) mice[J]. Front Physiol,2019,10:165.

[20] Pérez-Baos S,Barrasa JI,Gratal P,et al. Tofacitinib restores the inhibition of reverse cholesterol transport induced by inflammation:understanding the lipid paradox associated with rheumatoid arthritis[J]. Br J Pharmacol,2017,174(18):3018-3031.

[21] D’Amore S,Hardfeldt J,Cariello M,et al. Identification of miR-9-5p as direct regulator of ABCA1 and HDL-driven reverse cholesterol transport in circulating CD14+ cells of patients with metabolic syndrome[J]. Cardiovasc Res,2018,114(8):1154-1164.

[22] He P,Smith A,Gelissen IC,et al. The effect of statins and the synthetic LXR agonist T0901317 on expression of ABCA1 transporter protein in human lung epithelial cell lines in vitro[J]. Pharmacol Rep,2019,71(6):1219-1226.

[23] Westerterp M,Fotakis P,Ouimet M,et al. Cholesterol efflux pathways suppress inflammasome activation,NETosis,and atherogenesis[J]. Circulation,2018,138(9):898-912.

[24] Warnatsch A,Ioannou M,Wang Q,et al. Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis [J]. Science,2015,349(6245):316-320.

[25] D?ring Y,Soehnlein O,Weber C. Neutrophil extracellular traps in atherosclerosis and atherothrombosis[J]. Circ Res,2017,120(4):736-743.

[26] Kithcart AP,Libby P. Unfriendly fire from neutrophils promiscuously potentiates cardiovascular inflammation[J]. Circ Res,2017,121(9):1029-1031.

[27] Tall AR,Westerterp M. Inflammasomes, neutrophil extracellular traps,and cholesterol[J]. J Lipid Res,2019,60(4):721-727.

[28] Schumacher T,Benndorf RA. ABC transport proteins in cardiovascular disease—A brief summary[J]. Molecules,2017,22(4):589.

更新日期/Last Update: 2021-09-10