[1]朱志伦 田乃亮.急性冠脉综合征患者抗血小板降阶治疗方案研究进展[J].心血管病学进展,2021,(6):534.[doi:10.16806/j.cnki.issn.1004-3934.2021.06.014]
 ZHU Zhilun,TIAN Nailiang.Advances in De-Escalation of Anti-Platelet Therapy in Patients with Acute Coronary Syndrome[J].Advances in Cardiovascular Diseases,2021,(6):534.[doi:10.16806/j.cnki.issn.1004-3934.2021.06.014]
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急性冠脉综合征患者抗血小板降阶治疗方案研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2021年6期
页码:
534
栏目:
综述
出版日期:
2021-06-25

文章信息/Info

Title:
Advances in De-Escalation of Anti-Platelet Therapy in Patients with Acute Coronary Syndrome
作者:
朱志伦 田乃亮
(南京医科大学附属南京医院心内科,江苏 南京 210006)
Author(s):
ZHU ZhilunTIAN Nailiang
 (Department of Cardiology,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006, Jiangsu,China)
关键词:
急性冠脉综合征抗血小板治疗降阶治疗
Keywords:
Acute coronary syndromeAnti-platelet therapyDe-escalation strategy
DOI:
10.16806/j.cnki.issn.1004-3934.2021.06.014
摘要:
双联抗血小板治疗已成为急性冠脉综合征患者的标准治疗。然而随着新型强效P2Y12受体拮抗剂的出现,对于抗血小板药的选择和联合用药策略以及抗血小板治疗的最佳持续时间出现争议,争议的焦点在于预防血栓事件发生和防止出血风险过度增加之间如何取得平衡。大量的临床实践证实,并不存在绝对标准的抗血小板治疗方案,但根据实际情况逐渐降低抗血小板治疗强度,可在不增加缺血事件的同时减少出血事件,并减少其他药物不良事件发生,基于此提出的降阶治疗正成为急性冠脉综合征患者抗血小板治疗研究领域的新热点。
Abstract:
Dual anti-platelet treatment (DAPT) has become the standard treatment for patients with acute coronary syndrome (ACS). However,with the emergence of new powerful P2Y12 receptor inhibitors,there have been controversies over the choice of anti-platelet drugs and the combination therapy,and the optimal duration of anti-platelet therapy. The focus of the controversy is to achieve a balance between the prevention of thrombotic events and the prevention of increased bleeding risk. A large number of clinical practice has confirmed that there is no absolute standard anti-platelet therapy,but gradually reducing the anti-platelet intensity according to the real situation can reduce bleeding events and other adverse drug events without increasing ischemic events. Based on this,the de-escalation therapy is becoming a new hotspot in the research field of anti-platelet therapy for ACS patients

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