[1]张鹏 刘东升 张俊峰.血小板活化相关信号转导机制研究进展[J].心血管病学进展,2020,(10):1078.[doi:10.16806/j.cnki.issn.1004-3934.20.10.019]
　ZHANG Peng,LIU Dongsheng,ZHANG Junfeng.Signal Transduction Mechanism Related to Platelet Activation[J].Advances in Cardiovascular Diseases,2020,(10):1078.[doi:10.16806/j.cnki.issn.1004-3934.20.10.019]
点击复制

血小板活化相关信号转导机制研究进展()
分享到：

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年10期
页码:
1078
栏目:
综述
出版日期:
2020-10-25

文章信息/Info

Title:
Signal Transduction Mechanism Related to Platelet Activation
作者:
张鹏 刘东升 张俊峰
(上海交通大学医学院附属第九人民医院心血管内科,上海 201900)
Author(s):
ZHANG Peng;  LIU Dongsheng;  ZHANG Junfeng
(Department of Cardiology,Shanghai Ninth Peoples Hospital,Shanghai JiaoTong University School of Medicine,Shanghai 201900,China)
关键词:
血小板活化; 信号转导; 黏附受体; G蛋白偶联受体; 抗血小板药物
Keywords:
Platelet activation;  Signal transduction;  Adhesion receptors;  G-protein-coupled receptors;  Antiplatelet drugs
DOI:
10.16806/j.cnki.issn.1004-3934.20.10.019
摘要:
动脉血栓的形成是一个十分复杂的病理生理过程，涉血小板、血管以凝血抗凝系统间的相互作用，而血小板活化是动脉血栓形成的关键环节。通过回顾近年相关文献并结合最新研究结果，对以黏附受体和G蛋白偶联受体为核心的血小板活化相关信号转导过程，以抗血小板药物的临床使用研发进行综述。
Abstract:
The formation of arterial thrombosis is a extremely complex pathophysiological process,which involves the interaction between platelets,blood vessels and the coagulation and anticoagulation system,and platelet activation plays a crucial role in the formation of arterial thrombosis.By reviewing the recent literatures and combining with the latest research results,we reviewed the signal transduction process related to platelet activation with adhesion receptor and G-protein-coupled receptor as the core,as well as the clinical application and research of antiplatelet drugs.

参考文献/References:

[1] 胡盛寿润霖刘力生等. 《中国心血管病报告2018》概要[J]. 中国循环杂志2019,34(3):209-220.
[2] Hansen CE,Qiu Y,McCarty OJT,et al. Platelet mechanotransduction[J]. Annu Rev Biomed Eng,2018,20:253-275.
[3] Zhang XF,Zhang W,Quach ME,et al. Force-regulated refolding of the mechanosensory domain in the platelet glycoprotein Ⅰb-Ⅸ complex[J]. Biophys J,2019,116(10):1960-1969.
[4] Ju L,Chen Y,Xue L,et al. Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals[J]. Elife,2016,5:e15447.
[5] Rayes J,Watson SP,Nieswandt B. Functional significance of the platelet immune receptors GPVI and CLEC-2[J]. J Clin Invest,2019,129(1):12-23.
[6] Haining EJ,Cherpokova D,Wolf K,et al. CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice[J]. Blood,2017,130(20):2224-2228.
[7] Gao J,Huang M,Lai J,et al. Kindlin supports platelet integrin αⅡbβ3 activation by interacting with paxillin[J]. J Cell Sci,2017,130(21):3764-3775.
[8] Li H,Deng Y,Sun K,et al. Structural basis of kindlin-mediated integrin recognition and activation[J]. Proc Natl Acad Sci U S A,2017,114(35):9349-9354.
[9] Haydari Z,Shams H,Jahed Z,et al. Kindlin assists talin to promote integrin activation[J]. Biophys J,2020,118(8):1977-1991.
[10] Stefanini L,Bergmeier W. RAP GTPases and platelet integrin signaling[J]. Platelets,2019,30(1):41-47.
[11] Bromberger T,Klapproth S,Rohwedder I,et al. Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice[J]. Blood,2018,132(26):2754-2762.
[12] Gingras AR,Lagarrigue F,Cuevas MN,et al. Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem[J]. J Cell Biol,2019,218(6):1799-1809.
[13] Bromberger T,Zhu L,Klapproth S,et al. Rap1 and membrane lipids cooperatively recruit talin to trigger integrin activation[J]. J Cell Sci,2019,132(21):jcs235531.
[14] Raslan Z,Naseem KM. The control of blood platelets by cAMP signalling[J]. Biochem Soc Trans,2014,42(2):289-294.
[15] Laurent PA,Hechler B,Solinhac R,et al. Impact of PI3Kα(phosphoinositide 3-kinase alpha) inhibition on hemostasis and thrombosis[J]. Arterioscler Thromb Vasc Biol,2018,38(9):2041-2053.
[16] Laurent PA,Severin S,Hechler B,et al. Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate[J]. Blood,2015,125(5):881-888.
[17] Stefanini L,Paul DS,Robledo RF,et al. RASA3 is a critical inhibitor of RAP1-dependent platelet activation[J]. J Clin Invest,2015,125(4):1419-1432.
[18] Feghhi S,Tooley WW,Sniadecki NJ. Nonmuscle myosin ⅡA regulates platelet contractile forces through Rho kinase and myosin light-chain kinase[J]. J Biomech Eng,2016,138(10):1045061-1045064.
[19] Lu DH,Hsu CC,Huang SW,et al. ARHGEF10 knockout inhibits platelet aggregation and protects mice from thrombus formation[J]. J Thromb Haemost,2017,15(10):2053-2064.
[20] Qasim H,Karim ZA,Hernandez KR,et al. Arhgef1 plays a vital role in platelet function and thrombogenesis[J]. J Am Heart Assoc,2019,8(9):e011712.
[21] Jones S,Evans RJ,Mahaut-Smith MP. Ca2+ influx through P2X1 receptors amplifies P2Y1 receptor-evoked Ca2+ signaling and ADP-evoked platelet aggregation[J]. Mol Pharmacol,2014,86(3):243-251.
[22] Estevez B,Kim K,Delaney MK,et al. Signaling-mediated cooperativity between glycoprotein Ⅰb-Ⅸand protease-activated receptors in thrombin-induced platelet activation[J]. Blood,2016,127(5):626-636.
[23] Capra V,Mauri M,Guzzi F,et al. Impaired thromboxane receptor dimerization reduces signaling efficiency:A potential mechanism for reduced platelet function in vivo[J]. Biochem Pharmacol,2017,124:43-56.
[24] Lei X,Reheman A,Hou Y,et al. Anfibatide,a novel GPⅠb complex antagonist,inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis[J]. Thromb Haemost,2014,111(2):279-289.
[25] Franchi F,Rollini F,Angiolillo DJ. Antithrombotic therapy for patients with STEMI undergoing primary PCI[J]. Nat Rev Cardiol,2017,14(6):361-379.
[26] Dery JP,Mahaffey KW,Tricoci P,et al. Arterial access site and outcomes in patients undergoing percutaneous coronary intervention with and without vorapaxar[J]. Catheter Cardiovasc Interv,2016,88(2):163-173.
[27] Wong PC,Seiffert D,Bird JE,et al. Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding[J]. Sci Transl Med,2017,9(371):eaaf5294.

相似文献/References:

[1]王琼琼,赵胜.血小板活化在川崎病中的研究进展[J].心血管病学进展,2021,(6):552.[doi:10.16806/j.cnki.issn.1004-3934.2021.08.000]
　WANG QiongqiongZHAO Sheng.Platelet Activation in the Pathogenesis of Kawasaki Disease[J].Advances in Cardiovascular Diseases,2021,(10):552.[doi:10.16806/j.cnki.issn.1004-3934.2021.08.000]

备注/Memo

备注/Memo:
基金项目：国家自然科学基金面上项目（81670316）
更新日期/Last Update: 2020-12-21