[1]蔺雅娟 杨晓蕾 夏云龙.不同尿酸水平与心血管疾病之间的关系[J].心血管病学进展,2020,(9):911-913.[doi:10.16806/j.cnki.issn.1004-3934.2020.09.006]
　LIN Yajuan,YANG Xiaolei,XIA Yunlong.The Relationship Between Different Levels of Uric Acid and Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2020,(9):911-913.[doi:10.16806/j.cnki.issn.1004-3934.2020.09.006]
点击复制

不同尿酸水平与心血管疾病之间的关系()
分享到：

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年9期
页码:
911-913
栏目:
出版日期:
2020-09-25

文章信息/Info

Title:
The Relationship Between Different Levels of Uric Acid and Cardiovascular Disease
作者:
蔺雅娟 杨晓蕾 夏云龙
(大连医科大学附属第一医院心内科,辽宁 大连 116011)
Author(s):
LIN Yajuan; YANG Xiaolei;  XIA Yunlong
(Department of Cardiology,The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning, China)
关键词:
高尿酸血症; 低尿酸血症; 心血管疾病
Keywords:
Hyperuricemia; Hypouricemia; Cardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2020.09.006
摘要:
尿酸是人体中嘌呤经黄嘌呤氧化酶催化代谢的终产物。尿酸也被称为强效抗氧化剂，生理水平的尿酸能阻止H2O2诱导的超氧化物歧化酶的失活从而维持超氧化物歧化酶活性，起到抗氧化的作用。然而最近多项研究表明体内高尿酸血症与低尿酸血症均与多种心血管疾病的发生有关。现对体内不同程度尿酸水平与心血管疾病的发生做一综述。
Abstract:
Uric acid is the final product of purine catalyzed metabolism in human body by xanthine oxidase. Uric acid is also known as a potent antioxidant. Physiological levels of uric acid can prevent the inactivation of H2O2-induced superoxide dismutase, thus maintaining superoxide dismutase activity and playing an antioxidant role. However, a number of recent studies have shown that hyperuricemia and hypouricemia in vivo are associated with the occurrence of a variety of cardiovascular diseases. The purpose of this article is to review the occurrence of different levels of uric acid in vivo and cardiovascular diseases.

参考文献/References:

[1]Kuwabara M,Niwa K,Nishihara S,et al. Hyperuricemia is an independent competing risk factor for atrial fibrillation[J]. Int J Cardiol,2017,231:137-142.

[2]Kuwabara M,Niwa K,Hisatome I,et al. Asymptomatic hyperuricemia without comorbidities predicts cardiometabolic diseases:five-year Japanese cohort study[J]. Hypertension,2017,69(6):1036-1044.

[3]Ndrepepa G. Uric acid and cardiovascular disease[J]. Clin Chim Acta,2018,484:150-163.

[4]李莎,熊峰. 胰岛素抵抗和心血管疾病研究进展[J]. 心血管病学进展,2019,40(9):1307-1311.

[5]Johnson RJ,Sautin YY,Oliver WJ,et al. Lessons from comparative physiology:could uric acid represent a physiologic alarm signal gone awry in western society?[J]. J Comp Physiol B,2009,179(1):67-76.

[6]Desideri G,Castaldo G,Lombardi A,et al. Is it time to revise the normal range of serum uric acid levels?[J]. Eur Rev Med Pharmacol Sci,2014,18(9):1295-1306.

[7]Chen C,Lü JM,Yao Q. Hyperuricemia-related diseases and xanthine oxidoreductase (XOR) inhibitors:an overview[J]. Med Sci Monit,2016,22:2501-2512.

[8]Oda M,Satta Y,Takenaka O,et al. Loss of urate oxidase activity in hominoids and its evolutionary implications[J]. Mol Biol Evol,2002,19(5):640-653.

[9]Wu XW,Muzny DM,Lee CC,et al. Two independent mutational events in the loss of urate oxidase during hominoid evolution[J]. J Mol Evol,1992,34(1):78-84.

[10]Cejkova J,Ardan T,Filipec M,et al. Xanthine oxidoreductase and xanthine oxidase in human cornea[J]. Histol Histopathol,2002,17(3):755-760.

[11]Linder N,Rapola J,Raivio KO. Cellular expression of xanthine oxidoreductase protein in normal human tissues[J]. Lab Invest,1999,79(8):967-974.

[12]Choi HK,Atkinson K,Karlson EW,et al. Purine-rich foods, dairy and protein intake, and the risk of gout in men[J]. N Engl J Med,2004,350(11):1093-1103.

[13]Ames BN,Cathcart R,Schwiers E,et al. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer:a hypothesis[J]. Proc Natl Acad Sci U S A,1981,78(11):6858-6862.

[14]Glantzounis GK,Tsimoyiannis EC,Kappas AM,et al. Uric acid and oxidative stress[J]. Curr Pharm Des,2005,11(32):4145-4151.

[15]Hink HU,Santanam N,Dikalov S,et al. Peroxidase properties of extracellular superoxide dismutase:role of uric acid in modulating in vivo activity[J]. Arterioscler Thromb Vasc Biol,2002,22(9):1402-1408.

[16]Davies KJ,Sevanian A,Muakkassah-Kelly SF,et al. Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric acid[J]. Biochem J,1986,235(3):747-754.

[17]Mallat SG,Al Kattar S,Tanios BY,et al. Hyperuricemia,hypertension,and chronic kidney disease:an emerging association[J]. Curr Hypertens Rep,2016,18(10):74.

[18]Essex MN,Hopps M,Bienen EJ,et al. Evaluation of the relationship between serum uric acid levels and cardiovascular events in patients with gout:a retrospective analysis using electronic medical record data[J]. J Clin Rheumatol,2017,23(3):160-166.

[19]Gertler MM,Garn SM,Levine SA. Serum uric acid in relation to age and physique in health and in coronary heart disease[J]. Ann Intern Med,1951,34(6):1421-1431.

[20]Kannel WB,Castelli WP,Mcnamara PM. The coronary profile:12-year follow-up in the Framingham study[J]. J Occup Med,1967,9(12):611-619.

[21]Fang J,Alderman MH. Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey[J]. JAMA,2000,283(18):2404-2410.

[22]Li P,Zhang L,Zhang M,et al. Uric acid enhances PKC-dependent eNOS phosphorylation and mediates cellular ER stress:a mechanism for uric acid-induced endothelial dysfunction[J]. Int J Mol Med,2016,37(4):989-997.

[23]Cai W,Duan XM,Liu Y,et al. Uric acid induces endothelial dysfunction by activating the HMGB1/RAGE signaling pathway[J]. Biomed Res Int,2017,2017:4391920.

[24]Ekundayo OJ,DellItalia LJ,Sanders PW,et al. Association between hyperuricemia and incident heart failure among older adults:a propensity-matched study[J]. Int J Cardiol,2010,142(3):279-287.

[25]Wannamethee SG,Papacosta O,Lennon L,et al. Serum uric acid as a potential marker for heart failure risk in men on antihypertensive treatment:the British regional heart study[J]. Int J Cardiol,2018,252:187-192.

[26]Huang H,Huang B,Li Y,et al. Uric acid and risk of heart failure:a systematic review and meta-analysis[J]. Eur J Heart Fail,2014,16(1):15-24.

[27]Krishnan E. Hyperuricemia and incident heart failure[J]. Circ Heart Fail,2009,2(6):556-562.

[28]Verdecchia P,Schillaci G,Reboldi G,et al. Relation between serum uric acid and risk of cardiovascular disease in essential hypertension.The PIUMA study[J]. Hypertension,2000,36(6):1072-1078.

[29]Kamei K,Konta T,Hirayama A,et al. Associations between serum uric acid levels and the incidence of nonfatal stroke:a nationwide community-based cohort study[J]. Clin Exp Nephrol,2017,21(3):497-503.

[30]Kuo CF,See LC,Yu KH,et al. Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortality[J]. Rheumatology (Oxford),2013,52(1):127-134.

[31]Hsu SP,Pai MF,Peng YS,et al. Serum uric acid levels show a “ J-shaped” association with all-cause mortality in haemodialysis patients[J]. Nephrol Dial Transplant,2004,19(2):457-462.

[32]Suliman ME,Johnson RJ, García-López E,et al. J-shaped mortality relationship for uric acid in CKD[J]. Am J Kidney Dis,2006,48(5):761-771.

[33]Park C,Obi Y,Streja E,et al. Serum uric acid,protein intake and mortality in hemodialysis patients[J]. Nephrol Dial Transplant,2017,32(10):1750-1757.

[34]Richette P,Doherty M,Pascual E,et al. 2016 updated EULAR evidence-based recommendations for the management of gout[J]. Ann Rheum Dis,2017,76(1):29-42.

[35]Waring WS,Mcknight JA,Webb DJ,et al. Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers[J]. Diabetes,2006,55(11):3127-3132.

[36]Yu ZF,Bruce-Keller AJ,Goodman Y,et al. Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo[J]. J Neurosci Res,1998,53(5):613-625.

[37]Zhang B,Yang N,Lin SP,et al. Suitable concentrations of uric acid can reduce cell death in models of OGD and cerebral ischemia-reperfusion injury[J]. Cell Mol Neurobiol,2017,37(5):931-939.

相似文献/References:

[1]周颖 顾宁.基于高尿酸血症与高血压相关性的药物研究进展[J].心血管病学进展,2020,(6):630.[doi:10.16806/j.cnki.issn.1004-3934.2020.06.017]
　ZHOU Ying,GU Ning.Drugs Based on the Relationship Between Hyperuricemia and Hypertension[J].Advances in Cardiovascular Diseases,2020,(9):630.[doi:10.16806/j.cnki.issn.1004-3934.2020.06.017]
[2]王晓琪 苏冠华.高尿酸血症和心力衰竭的病理生理机制、治疗和预后价值[J].心血管病学进展,2021,(9):780.[doi:10.16806/j.cnki.issn.1004-3934.2021.09.000]
　WANG Xiaoqi,SU Guanhua.Pathophysiological Mechanism, Treatment and Prognostic Value of Hyperuricemia and Heart Failure[J].Advances in Cardiovascular Diseases,2021,(9):780.[doi:10.16806/j.cnki.issn.1004-3934.2021.09.000]
[3]卢燕 刘亚萍 罗强 张全波 汪汉.肠道菌群及其代谢物与痛风[J].心血管病学进展,2023,(2):177.[doi:10.16806/j.cnki.issn.1004-3934.2023.02.018]
　LU Yan,LIU Yaping,LUO Qiang,et al.Intestinal Flora and Its Metabolites and Gout[J].Advances in Cardiovascular Diseases,2023,(9):177.[doi:10.16806/j.cnki.issn.1004-3934.2023.02.018]
[4]阿依努·艾力 布威阿依谢姆·努尔麦麦提 阿迪拉·阿扎提 迪丽达尔·希力甫.雌雄性大鼠高尿酸血症动物模型的动态比较[J].心血管病学进展,2023,(3):277.[doi:10.16806/j.cnki.issn.1004-3934.2023.03.019]
　Aynur·Aili,Buviayxem·Nurmamat,Adila·Azat,et al.Dynamic Comparison of Hyperuricemia Animal Model in Male and Female Rats[J].Advances in Cardiovascular Diseases,2023,(9):277.[doi:10.16806/j.cnki.issn.1004-3934.2023.03.019]

备注/Memo

备注/Memo:
基金项目：国家自然科学基金(81900439/81970286） 通信作者：夏云龙，E-mail:yunlong_xia@126.com 收稿日期：2020-03-06
更新日期/Last Update: 2020-12-02