[1]陈涛 张大勇 袁明 魏天龙.急性ST段抬高型心肌梗死患者血miRNA-499a与心肌损伤标志物的相关性分析[J].心血管病学进展,2020,(9):994-998.[doi:10.16806/j.cnki.issn.1004-3934.2020.09.025]
　CHEN Tao,ZHANG Dayong,YUAN Ming,et al.Correlation Between Serum miRNA-499a and Myocardial Injury Markers in Patients with Acute ST-Segment Elevation Myocardial Infarction[J].Advances in Cardiovascular Diseases,2020,(9):994-998.[doi:10.16806/j.cnki.issn.1004-3934.2020.09.025]
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急性ST段抬高型心肌梗死患者血miRNA-499a与心肌损伤标志物的相关性分析()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年9期
页码:
994-998
栏目:
出版日期:
2020-09-25

文章信息/Info

Title:
Correlation Between Serum miRNA-499a and Myocardial Injury Markers in Patients with Acute ST-Segment Elevation Myocardial Infarction
作者:
陈涛 张大勇 袁明 魏天龙
（四川绵阳四0四医院心内科，四川 绵阳 621000）
Author(s):
CHEN Tao;  ZHANG Dayong;  YUAN Ming;  WEI Tianlong
(Department of Cardiology,Sichuan Mianyang 404 Hospital,Mianyang 621000,Sichuan,China)
关键词:
急性心肌梗死; miRNA-499a; 心肌损伤; 相关性
Keywords:
Acute myocardial infarction; miRNA-499a; Myocardial injury; Correlation
DOI:
10.16806/j.cnki.issn.1004-3934.2020.09.025
摘要:
目的 探讨急性ST段抬高型心肌梗死（STEMI）患者血清微小RNA-499a（miRNA-499a）与心肌损伤标志物的相关性。方法 以2018年6月—2019年6月本院诊治的65例STEMI患者纳为STEMI组，同期在本院健康体检65例志愿者为对照组，比较两组来院即刻血清miRNA-499a与心肌损伤标志物[血清肌红蛋白（Mb）和肌钙蛋白I（cTnI）]水平，动态监测STEMI患者入院后血清miRNA-499a、Mb、cTnI水平，ROC曲线分析miRNA-499a、Mb和cTnI水平对STEMI的预测价值，并对STEMI患者血清miRNA-499a水平与Mb和cTnI水平进行相关性分析。结果 STEMI组血清miRNA-499a、Mb和cTnI水平较对照组明显高（P＜0.05），STEMI患者入院后4 h、8 h、12 h、24 h、48 h和72 h血清miRNA-499a、Mb和cTnI水平先明显升高后降低（P＜0.05），其中miRNA-499a在患者入院后12 h达最高峰，Mb在入院后8 h达最高峰，而cTnI于入院后24 h达最高峰。ROC曲线分析发现血清miRNA-499a、Mb和cTnI预测STEMI曲线下面积为0.804、0.889和0.921，且miRNA-499a预测STEMI的灵敏度与Mb相当（84.4% vs 85.5%），但较cTnI（80.3%）高，而其特异度与血清cTnI的相当（90.5% vs 91.6%），但较血清Mb（80.1%）高。Pearson相关性分析提示STEMI患者血清miRNA-499a水平与Mb和cTnI水平均呈明显正相关（r=0.418、0.542，P＜0.05）。结论 STEMI患者血清miRNA-499a水平与心肌损伤标志物（Mb和cTnI）存在明显相关性，miRNA-499a在STEMI诊断中具备Mb的高灵敏度和cTnI的高特异度，或可作为STEMI早期诊断的一种新型有效标志物。
Abstract:
Objective To investigate the correlation between serum microRNA-499a (miRNA-499a) and myocardial injury markers in patients with acute ST-segment elevation myocardial infarction(STEMI). Methods 65 patients with STEMI who were diagnosed and treated in our hospital during the period from June 2018 to June 2019 were included in the STEMI group. 65 volunteers who completed health examination in our hospital during the same period were selected as the control group. Levels of serum miRNA-499a and myocardial injury markers [serum myoglobin(Mb), troponin I(cTnI)] were compared between the two groups immediately after admission and were monitored dynamically after admission. The value of miRNA-499a, Mb and cTnI levels in predicting STEMI was analyzed with ROC curve. The correlation between serum miRNA-499a levels and Mb, cTnI levels in patients with STEMI was analyzed. Results The levels of serum miRNA-499a, Mb and cTnI in STEMI group were significantly higher than those in the control group (P<0.05). The levels of above indicators in STEMI group firstly increased significantly and then decreased at 4 h, 8 h, 12 h, 24 h, 48 h and 72 h after admission. miRNA-499a, Mb and cTnI levels reached the highest peaks at 12 h, 8 h and 24 h after admission respectively. ROC curve analysis found that areas under curves of serum miRNA-499a and myocardial injury markers in predicting STEMI were 0.804, 0.889 and 0.921 respectively. The sensitivity of serum miRNA-499a in predicting STEMI was similar to Mb (84.4% vs 85.5%), but higher than cTnI (80.3%). The specificity is similar to serum cTnI (90.5% vs 91.6%), but higher than serum Mb (80.1%). Pearson correlation analysis showed that serum miRNA-499a levels in patients with STEMI were significantly positively correlated with Mb and cTnI levels (r=0.418, 0.542, P<0.05). Conclusion Serum miRNA-499a levels are significantly correlated with myocardial injury markers(Mb and cTnI) in patients with STEMI. The sensitivity of serum miRNA-499a is as high as that of Mb and the specificity is as high as that of cTnI in the diagnosis of STEMI. It can be used as an new effective marker for early diagnosis of STEMI .

参考文献/References:

[1]Thiele H,Akin I,Sandri M,et al. PCI strategies in patients with acute myocardial infarction and cardiogenic shock[J]. N Engl J Med,2017,377(25):2419-2432. [2]Fan J,Ma J,Xia N,et al. Clinical value of combined detection of CK-MB, MYO, cTnI a nd plasma NT-proBNP in diagnosis of acute myocardial infarction[J]. Clin Lab,2017,63(3): 427-433. [3]谷阳,史亚非,张刚,等. 急性ST段抬高型心肌梗死患者血浆中性粒细胞明胶酶相关脂质运载蛋白水平与梗死后心室重构的相关性研究[J]. 心血管病学进展,2019,40(5):836-840. [4]Li XD,Yang YJ,Wang LY,et al. Elevated plasma miRNA-122,-140-3p,-720,-2861,and -3149 during early period of acute coronary syndrome are derived from peripheral blood mononuclear cells[J]. PLoS One,2017,12(9):e0184256. [5] Mohseni Z,Spaanderman MEA,Oben J,et al. Cardiac remodelling and preeclampsia:an overview of overlapping circulating miRNAs[J]. Ultrasound Obstet Gynecol,2017,52(3):310-317. [6]沈卫峰,贝正平.心血管病诊疗标准[M].上海：上海科学普及出版社,2013:423-425. [7]中华医学会心血管病学分会,中华心血管病杂志编辑委员会,《中国循环杂志》编辑委员会. 急性心肌梗死诊断和治疗指南[J]. 中华心血管病杂志,2001,29(12):710-725. [8]Shumyantseva VV,Bulko TV,Sigolaeva LV,et al. Molecular imprinting coupled with electrochemical analysis for plasma samples classification in acute myocardial infarction diagnostic[J]. Biosens Bioelectron,2018,99:216-222. [9]Ye XD,He Y,Wang S,et al.Heart-type fatty acid binding protein(H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis[J]. Acta Pharmacol Sin,2018,39(7):1155-1163. [10] Debnath T,Deb Nath NC,Kim EK,et al. Role of phytochemicals in the modulation of miRNA expression in cancer[J]. Food Funct,2017,8(10):3432-3442. [11] 许丽霞,张丽科,杨云山,等. 微小RNA-499对STEMI的早期诊断价值[J]. 检验医学与临床,2017,14(21):63-64. [12] 张家仕. miRNA-499与冠心病中医证型的相关性研究[D]. 广州中医药大学,2014. [13] Pisano F,Altomare C,Cervio E,et al. Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation[J]. Stem Cells,2015,33(4):1187-1199. [14]李祥云,蔡成松,潘峰,等. microRNA-208在急性心肌梗死病人血清中的变化[J]. 医学研究杂志,2013,42(6):62-65. [15]Wang XY,Chen XL,Huang ZQ,et al. MicroRNA-499-5p regulates porcine myofiber specification by controlling Sox6 expression[J]. Animal,2017,11(12):2268-2274.

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备注/Memo

备注/Memo:
基金项目：四川省科技计划项目（17YFHM007） 通信作者：陈涛，E-mail：13408107377@163.com 收稿日期：2020-01-08
更新日期/Last Update: 2020-12-04