[1]马丽 黄从新.单核细胞/淋巴细胞比率与冠状动脉病变程度相关性的临床研究[J].心血管病学进展,2020,(5):542-546.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.024]
　MA Li,HUANG Congxin.Association Between Monocyte to Lymphocyte Ratio and Severity of Coronary Artery Disease[J].Advances in Cardiovascular Diseases,2020,(5):542-546.[doi:10.16806/j.cnki.issn.1004-3934.2020.05.024]
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单核细胞/淋巴细胞比率与冠状动脉病变程度相关性的临床研究()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年5期
页码:
542-546
栏目:
出版日期:
2020-05-25

文章信息/Info

Title:
Association Between Monocyte to Lymphocyte Ratio and Severity of Coronary Artery Disease
作者:
马丽 黄从新
(武汉大学人民医院心内科 武汉大学心血管病研究所 心血管病湖北省重点实验室,湖北 武汉 430060)
Author(s):
MA Li; HUANG Congxin
(Department of Cardiology, Renmin Hospital of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology; Wuhan 430060,Hubei,China)
关键词:
冠状动脉病变; 单核细胞/淋巴细胞比率; Gensini评分
Keywords:
Coronary artery disease;  Monocyte to lymphocyte ratio;  Gensini scores
DOI:
10.16806/j.cnki.issn.1004-3934.2020.05.024
摘要:
目的 探讨单核细胞/淋巴细胞比率（MLR）与冠状动脉病变（CAD）程度的相关性。方法 连续入选2019年6月—9月于武汉大学人民医院心内科就诊的接受了冠状动脉造影的患者171例，按照MLR三分位数水平将所有入选者分为低MLR（≤0.28）、中MLR（0.28＜MLR≤0.41）（这样表述行否？？）和高MLR（＞0.41）三组，比较各组入选病例的临床基线资料和实验室指标的差异，比较三组的Gensini评分的差异和MLR与Gensini评分的相关性，用logistic回归分析影响CAD程度的危险因素。结果 三组的CAD支数情况不同（x2=13.626,P=0.034），冠心病亚型比例不同（x2=21.218,P=0.007），高MLR组有较高比例的三支病变以及较高比例的急性心肌梗死；高MLR的CAD严重程度较低MLR组的更重[Gensini评分（40.03±32.91） vs （20.62±25.71）,P=0.003]，且MLR比值与Gensini评分显著正相关（r=0.291,P=0.003）；logistic回归分析显示在校正所有基线差异后，MLR仍然与CAD程度显著正相关，其中中MLR组较低MLR组的患者增加冠状动脉中重度病变的风险为3.62倍（P=0.022），高MLR组的患者较低MLR组患者增加冠状动脉中重度病变的风险为3.03倍（P=0.045）。结论 MLR是CAD程度的独立预测因子。
Abstract:
Objective To investigate the association between monocyte to lymphocyte ratio(MLR) and the severity of coronary artery disease(CAD). Method A total of 171 patients who underwent coronary angiography at the Department of Cardiology, Wuhan University People’s Hospital from June 2019 to September 2019 were selected consecutively. All the patients were classified as three groups including low MLR(≤0.28), middle MLR(（0.28＜MLR≤0.41）（这样表述行否？？） and high MLR(＞0.41) according to the average MLR tertile. The clinical baseline data, laboratory indicators, and Gensini scores of the selected cases in each group were compared. The correlation between MLR and Gensini score was analyzed. Logistic regression was used to analyze the risk factors affecting the severity of coronary artery disease. Results The number of coronary lesions in the three groups was different(x2=13.626, P=0.034), and the proportion of coronary heart disease subtypes was different (x2=21.218, P=0.007). The high MLR group had a higher proportion of three coronary lesions and a higher proportion of acute myocardial infarction. Coronary lesions were more severe in the high MLR group than in the low MLR group[Gensini score(40.03±32.91) vs (20.62±25.71), P=0.003], and the MLR ratio was significantly positively correlated with the Gensini score(r=0.291, P=0.003). Logistic regression analysis showed that after correcting for all baseline differences, MLR was still significantly positively associated with the severity of coronary artery disease. Compared with patients in the low MLR group, the risk of coronary artery moderate to severe lesions was increased by 3.62 times in the patients with the middle MLR group(P=0.022), and the risk was increased by 3.03 times in patients with the high MLR group(P=0.045). Conclusion MLR may be an independent predictor of the severity of coronary artery disease

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备注/Memo

备注/Memo:
收稿日期：2019-12-15
更新日期/Last Update: 2020-08-12