[1]刘滔,汪汉,邱明仙,等.中粒细胞/淋巴细胞比值干燥综合征患者肺动脉压力的相关研究[J].心血管病学进展,2020,(3):328-332.[doi:10.16806/j.cnki.issn.1004-3934.20.03.028]
　LIU Tao,WANG Han,QIU Mingxian,et al.The Relationship Between Neutrophil/lymphocyte Ratio and Pulmonary Artery Pressure in Patients with Sjogrens Syndrome[J].Advances in Cardiovascular Diseases,2020,(3):328-332.[doi:10.16806/j.cnki.issn.1004-3934.20.03.028]
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中粒细胞/淋巴细胞比值干燥综合征患者肺动脉压力的相关研究()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年3期
页码:
328-332
栏目:
论著
出版日期:
2020-03-25

文章信息/Info

Title:
The Relationship Between Neutrophil/lymphocyte Ratio and Pulmonary Artery Pressure in Patients with Sjogrens Syndrome
作者:
刘滔1 ;  汪汉2 ;  邱明仙1;  吴镜2;  徐俊波1
（1.遵义医科大学，贵州 遵义 563003；2.成都市第三人民医院心内科，四川 成都610031）
Author(s):
LIU Tao1;  WANG Han2;  QIU Mingxian1;  WU Jing2;  XU Junbo1
（1.Zunyi Medical University,Zunyi 563003,Guizhou,China 2.Department of Cardiology,The Third Peoples Hospital of Chengdu, Chengdu 610031,Sichuan,China)
关键词:
中粒细胞/淋巴细胞比值; 干燥综合征; 肺动脉压力
Keywords:
Neutrophil/lymphocyte ratio; Sjogrens Syndrome ; Pulmonary artery pressure
DOI:
10.16806/j.cnki.issn.1004-3934.20.03.028
摘要:
目的 探讨中粒细胞/淋巴细胞比值（NLR）干燥综合征SS）患者肺动脉压力的相关。方法 回顾分析98例患者，根据肺动脉压力分为肺动脉压组18例和非肺动脉压组80例。比较两组患者临床特征和实验室检查指标，采用Spearman相关分析分析NLRSS患者肺动脉压力的相关，采用多因素分析探讨SS患者肺动脉压力肺动脉压的相关因素。行受试者工作特征曲线分析，探讨NLR预测SS患者发生肺动脉压的最佳界值。结果 两组患者、白细胞计数、中粒细胞计数、NLR、红细胞计数、血红蛋白总胆固醇水平比较，差异有统计学意义P＜0.05）。Spearman相关分析结果显示，NLR水平SS患者肺动脉压力呈正相关r=0.881，P＜0.05）。多元线回归分析结果显示，NLRSS患者肺动脉压力相关β= 4.812，95% CI 3.581～6.043，P＜0. 05。多因素logistic回归分析结果显示，NLROR 1.817，95% CI 1.0093.272，P =0.047）OR 1.302，95% CI 1.086～1.561P =0.004）均SS患者肺动脉压有关P＜0.05。受试者工作特征曲线分析显示NLR截断值为2.33时对SS患者发生肺动脉压有较好的预测（灵敏度为84.2%，特异度为61%）。结论 NLRSS患者肺动脉压力有关，且NLR水平对SS患者肺动脉压具有一定的预测价值。
Abstract:
Objective To investigate the correlation between neutrophil/lymphocyte ratio and pulmonary artery pressure in patients with Sjogrens syndrome.Methods A retrospective analysis of 98 patients with Sjogrens syndrome was performed according to pulmonary artery pressure in 18 patients with pulmonary arterial hypertension and 80 patients with non-pulmonary arterial hypertension. Clinical features and laboratory examination results of the two groups were compared.The correlation between neutrophil/lymphocyte ratio and pulmonary artery pressure in patients with Sjogrens syndrome was analyzed by Spearman correlation. Multivariate analysis was used to investigate the related factors of pulmonary artery pressure and pulmonary hypertension in patients with Sjogrens syndrome.Receiver operator characteristic(ROC) curve analysis was performed to investigate the optimal cut-off point of NLR in predicting pulmonary hypertension in patients with Sjogrens syndrome.Results There were statistically significant differences of C-reactive protein(CRP)，WBC，neutrophil count，NLR，RBC，HGB，TC between the two groups (P＜0.05).Spearman correlation analysis showed that NLR levels were positively correlated with pulmonary artery pressure in patients with Sjogrens syndrome(r=0.881,P＜0.05.Multiple linear regression analysis showed that NLR was associated with pulmonary artery pressure in patients with Sjogrens syndrome(β=4.812,95% CI 3.581～6.043P＜0. 05.Multivariate logistic regression analysis showed that NLR(OR 1.817,95% CI 1.009～3.272,P=0.047) and CRP(OR 1.302,95% CI 1.086～1.561P=0.004) were associated with pulmonary arterial hypertension in patients with Sjogrens syndrome(P＜0.05).ROC curve analysis showed that the NLR cut-off value of 2.33 had a good prediction of pulmonary hypertension in patients with Sjogrens syndrome (the sensitivity was 84.2% and the specificity was 61%).Conclusion NLR is associated with pulmonary artery pressure in patients with Sjogrens syndrome,and NLR levels have predictive value for pulmonary arterial hypertension in patients with Sjogrens syndrome

参考文献/References:


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备注/Memo

备注/Memo:
收稿时间：2019-10-26 基金项目：四川省卫生和计划生育委员会2018科研课题（18PJ377） 通讯作者：徐俊波，E-mail：xujunbo2000@sina.com
更新日期/Last Update: 2020-05-20