[1]何淼 何燕.基于网络药理学探索速效救心丸治疗不稳定型心绞痛的作用机制[J].心血管病学进展,2019,(9):1329-1335.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.036]
　HE MiaoHE Yan.The Mechanism of Suxiao Jiuxin Pill in Treatment of Unstable Angina Based on Pharmacological Network[J].Advances in Cardiovascular Diseases,2019,(9):1329-1335.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.036]
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基于网络药理学探索速效救心丸治疗不稳定型心绞痛的作用机制()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年9期
页码:
1329-1335
栏目:
论著
出版日期:
2019-12-25

文章信息/Info

Title:
The Mechanism of Suxiao Jiuxin Pill in Treatment of Unstable Angina Based on Pharmacological Network
作者:
何淼 何燕
 (广西医科大学第一附属医院老年心血管内科,广西 南宁 530021)
Author(s):
HE MiaoHE Yan
(Department of Geriatric Cardiology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina)
关键词:
网络药理; 速效救心丸; 不稳定型心绞痛; 作用机制
Keywords:
Pharmacological network;  Suxiao jiuxin pill;  Unstable angina;  Mechanism
DOI:
10.16806/j.cnki.issn.1004-3934.2019.09.036
摘要:
目的 基于网络药理学方法，探索速效救心丸治疗不稳定型心绞痛的作用机制。方法 利用中药靶点数据库（SymMap数据库）、中药系统药理学数据库和分析平台（TCMSP数据库）筛选速效救心丸活性成分及靶点。通过GeneCards数据库挖掘不稳定型心绞痛靶点。采用功能蛋白联合网络数据库（STRING数据库）制作药物-靶点的蛋白质-蛋白质交互作用网络及不稳定型心绞痛-靶点的蛋白质-蛋白质交互作用网络，将两个网络信息导入Cytoscape软件取网络交集靶点，得到速效救心丸治疗不稳定型心绞痛的靶点，通过ClueGO插件对重叠靶点进行基因本体富集分析及基于京都基因与基因组百科全书信号通路分析。结果 分析得到速效救心丸治疗不稳定型心绞痛相关的靶点32个，主要涉及131个生物过程，16条信号通路。结论 基于网络药理学方法挖掘速效救心丸治疗不稳定型心绞痛的治疗靶点、信号通路，为研究速效救心丸治疗不稳定型心绞痛的作用机制提供了新的研究方法。
Abstract:
Objective This paper aims to discuss the mechanism of Suxiao Jiuxin Pill in treatment of unstable angina based on pharmacological network. Methods Possible intake active components and targets of Suxiao Jiuxin Pill were screened out and predicted by SymMap Databases and TCMSP Databases. Unstable angina targets were mined through the GeneCards database. Protein-protein interaction network of component-targets and disease-targets were mapped by functional protein association networks (STRING), and the intersectio n of the two networks was obtained using Cytoscape software. The gene ontology and KEGG pathway of the intersection network were analyzed by ClueGO plug-ins. Results 32 targets related to unstable angina pectoris were treated with Suxiao Jiuxin Pill, which were mainly involved in 131 biological processes and 16 signaling pathways. Conclusion This research explores the possible target and signaling pathway of Suxiao Jiuxin Pill in the treatment of unstable angina. It provides a new research direction for the follow-up study of the mechanism of Suxiao Jiuxin Pill for unstable angina.

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更新日期/Last Update: 2020-02-06