[1]王爱荣,江高峰.放射治疗致心血管疾病的研究进展[J].心血管病学进展,2020,(3):242-246.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.007]
 WANG Airong,JIANG Gaofeng.Radiation-induced Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2020,(3):242-246.[doi:10.16806/j.cnki.issn.1004-3934.2020.03.007]
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放射治疗致心血管疾病的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年3期
页码:
242-246
栏目:
综述
出版日期:
2020-03-25

文章信息/Info

Title:
Radiation-induced Cardiovascular Disease
作者:
王爱荣 江高峰
(武汉科技大学附属天佑医院转化医学中心 肿瘤免疫治疗研究所,湖北 武汉 430064)
Author(s):
WANG Airong JIANG Gaofeng
(Center for Translational Medicine,Institute for Cancer Immunotherapy,Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan 430064, Hubei, China)
关键词:
放射治疗肿瘤心血管疾病
Keywords:
Radiation therapy Tumor Cardiovascular disease
DOI:
10.16806/j.cnki.issn.1004-3934.2020.03.007
摘要:
近年来,随着恶性肿瘤综合治疗技术的不断进步,恶性肿瘤患者的生存期不断延长,放射治疗导致的远期不良心血管事件正逐渐成为影响恶性肿瘤患者预后和生存质量的重要因素。现综述放射治疗致心血管疾病的最新研究进展。
Abstract:
In recent years,with the continuous advancement of comprehensive treatment techniques for malignant tumors,patients with malignant tumors live longer and longer. Long-term adverse cardiovascular events caused by radiation therapy are becoming an important factor affecting the prognosis and quality of life of patients with malignant tumors. This paper reviews the research progress of radiation-induced cardiovascular disease

参考文献/References:

[1] Fidler MM,Reulen RC,Henson K,et al. Population-based long-term cardiac-specific mortality among 34 489 five-year survivors of childhood cancer in great britain[J]. Circulation,2017,135(10):951-963.

[2] McGale P,Darby SC,Hall P,et al. Incidence of heart disease in 35,000 women treated with radiotherapy for breast cancer in Denmark and Sweden[J]. Radiother Oncol,2011,100(2):167-175.

[3]熊青松,凌智瑜. 心律失常射频导管消融的放射防护[J]. 心血管病学进展,2018,39(5):751-754.

[4] Mulrooney DA,Armstrong GT,Huang S,et al. Cardiac outcomes in adult survivors of childhood cancer exposed to cardiotoxic therapy:a cross-sectional study[J]. Ann Intern Med,2016,164(2):93-101.

[5] Boero IJ,Paravati AJ,Triplett DP,et al. Modern radiation therapy and cardiac outcomes in breast cancer[J]. Int J Radiat Oncol Biol Phys,2016,94(4):700-708.

[6] Preston DL,Shimizu Y,Pierce DA,et al. Studies of mortality of atomic bomb survivors. Report 13:solid cancer and noncancer disease mortality:1950-1997. 2003[J]. Radiat Res,2012,178(2):AV146-172.

[7] Yusuf SW,Sami S,Daher IN. Radiation-induced heart disease:a clinical update[J]. Cardiol Res Pract,2011,2011:1-9.

[8] Yentrapalli R,Azimzadeh O,Sriharshan A,et al. The PI3K/Akt/mTOR pathway is implicated in the premature senescence of primary human endothelial cells exposed to chronic radiation[J]. PLoS One,2013,8(8):e70024.

[9] Mun GI,Boo YC. Identification of CD44 as a senescence-induced cell adhesion gene responsible for the enhanced monocyte recruitment to senescent endothelial cells[J]. Am J Physiol Heart Circ Physiol,2010,298(6):H2102-H2111.

[10] Halle M,Gabrielsen A,Paulsson-Berne G,et al. Sustained inflammation due to nuclear factor-kappa B activation in irradiated human arteries[J]. J Am Coll Cardiol,2010,55(12):1227-1236.

[11] Dong X,Tong F,Qian C,et al. NEMO modulates radiation-induced endothelial senescence of human umbilical veins through NF-kappaB signal pathway[J] .Radiat Res,2015,183(1):82-93.

[12] Elmore S. Apoptosis:a review of programmed cell death[J]. Toxicol Pathol,2007,35(4):495-516.

[13] Seideman JH,Stancevic B,Rotolo JA,et al. Alpha particles induce apoptosis through the sphingomyelin pathway[J]. Radiat Res,2011,176(4):434-446.

[14] Prabhakarpandian B,Goetz DJ,Swerlick RA,et al. Expression and functional significance of adhesion molecules on cultured endothelial cells in response to ionizing radiation[J]. Microcirculation,2001,8(5):355-364.

[15] Pathak R,Wang J,Garg S,et al. Recombinant thrombomodulin (solulin) ameliorates early intestinal radiation toxicity in a preclinical rat model[J]. Radiat Res,2016,186(2):112-120.

[16] Sugihara T,Hattori Y,Yamamoto Y,et al. Preferential impairment of nitric oxide-mediated endothelium-dependent relaxation in human cervical arteries after irradiation[J]. Circulation,1999,100(6):635-641.

[17] Beckman JS,Crow JP. Pathological implications of nitric oxide,superoxide and peroxynitrite formation[J]. Biochem Soc Trans,1993,21(2):330-334.

[18] Linard C,Marquette C,Mathieu J,et al. Acute induction of inflammatory cytokine expression after gamma-irradiation in the rat:effect of an NF-kappaB inhibitor[J]. Int J Radiat Oncol Biol Phys,2004,58(2):427-434.

[19] Mezzaroma E,Mikkelsen RB,Toldo S,et al. Role of interleukin-1 in radiation-induced cardiomyopathy[J]. Mol Med,2015,21:210-218.

[20] Venkatesulu BP,Mahadevan LS,Aliru ML,et al. Radiation-induced endothelial vascular injury:a review of possible mechanisms[J]. JACC Basic Transl Sci,2018,3(4):563-572.

[21] Darby SC,Ewertz M,McGale P,et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer[J]. N Engl J Med,2013,368(11):987-998.

[22] Marks LB,Yu X,Prosnitz RG,et al. The incidence and functional consequences of RT-associated cardiac perfusion defects[J]. Int J Radiat Oncol Biol Phys,2005,63(1):214-223.

[23] Heidenreich PA,Schnittger I,Strauss HW,et al. Screening for coronary artery disease after mediastinal irradiation for Hodgkins disease[J]. J Clin Oncol,2007,25(1):43-49.

[24] Caro-Codon J,Jimenez-Valero S,Galeote G,et al. Radiation-induced coronary artery disease:useful insights from OCT[J]. Int J Cardiol,2016,202:535-536.

[25] Brown ML,Schaff HV,Sundt TM. Conduit choice for coronary artery bypass grafting after mediastinal radiation[J]. J Thorac Cardiovasc Surg,2008,136(5):1167-1171.

[26] Brosius FC 3rd,Waller BF,Roberts WC. Radiation heart disease. Analysis of 16 young (aged 15 to 33 years) necropsy patients who received over 3,500 rads to the heart[J]. Am J Med,1981,70(3):519-530.

[27] Bijl JM,Roos MM,van Leeuwen-Segarceanu EM,et al. Assessment of valvular disorders in survivors of Hodgkins lymphoma treated by mediastinal radiotherapy +/- chemotherapy[J]. Am J Cardiol,2016,117(4):691-696.

[28] Cutter DJ,Schaapveld M,Darby SC,et al. Risk of valvular heart disease after treatment for Hodgkin lymphoma[J]. J Natl Cancer Inst,2015,107(4):djv008-djv008.

[29] Heidenreich PA,Hancock SL,Lee BK,et al. Asymptomatic cardiac disease following mediastinal irradiation[J]. J Am Coll Cardiol,2003,42(4):743-749.

[30] Cuomo JR,Sharma GK,Conger PD,et al. Novel concepts in radiation-induced cardiovascular disease[J]. World J Cardiol,2016,8(9):504-519.

[31] Ogino I,Watanabe S,Iwahashi N,et al. Symptomatic radiation-induced cardiac disease in long-term survivors of esophageal cancer[J]. Strahlenther Onkol,2016,192(6):359-367.

[32] Hoit BD. Pathophysiology of the pericardium[J]. Prog Cardiovasc Dis,2017,59(4):341-348.

[33] Mousavi N,Nohria A. Radiation-induced cardiovascular disease[J]. Curr Treat Options Cardiovasc Med,2013,15(5):507-517.

[34] Yusuf SW,Hassan SA,Mouhayar E,et al. Pericardial disease:a clinical review[J]. Expert Rev Cardiovasc Ther,2016,14(4):525-539.

[35] Yusuf SW,Howell RM,Gomez D,et al. Radiation-related heart and vascular disease[J]. Future Oncol,2015,11(14):2067-2076.

[36] Guldner L,Haddy N,Pein F,et al. Radiation dose and long term risk of cardiac pathology following radiotherapy and anthracyclin for a childhood cancer[J]. Radiother Oncol,2006,81(1):47-56.

[37] Al-Kindi SG,Oliveira GH. Heart transplantation outcomes in radiation-induced restrictive cardiomyopathy[J]. J Card Fail,2016,22(6):475-478.

[38] Marmagkiolis K,Finch W,Tsitlakidou D,et al. Radiation toxicity to the cardiovascular system[J]. Curr Oncol Rep,2016,18(3):15.

[39] Groarke JD,Tanguturi VK,Hainer J,et al. Abnormal exercise response in long-term survivors of hodgkin lymphoma treated with thoracic irradiation:evidence of cardiac autonomic dysfunction and impact on outcomes[J]. J Am Coll Cardiol,2015,65(6):573-583.

[40] Hoca A,Yildiz M,Ozyigit G. Evaluation of the effects of mediastinal radiation therapy on autonomic nervous system[J]. Med Oncol,2012,29(5):3581-3586.

[41] Huang CC,Huang TL,Hsu HC,et al. Long-term effects of neck irradiation on cardiovascular autonomic function:a study in nasopharyngeal carcinoma patients after radiotherapy[J]. Muscle Nerve,2013,47(3):344-350.

[42] Aung T,Fan W,Krishnamurthy M. Recurrent syncope,orthostatic hypotension and volatile hypertension:think outside the box [J]. J Community Hosp Intern Med Perspect,2013,3(2):45-49.

[43] Lancellotti P,Nkomo VT,Badano LP,et al. Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults:a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography[J]. J Am Soc Echocardiogr,2013,26(9):1013-1032.

[44] 关旭敏,杨晓蕾,夏云龙. 心血管疾病危险因素对肿瘤的作用[J]. 心血管病学进展,2017,38(5):616-619.

[45] Doi H,Matsumoto S,Odawara S,et al. Pravastatin reduces radiation-induced damage in normal tissues[J]. Exp Ther Med,2017,13(5):1765-1772.

[46] Jang H,Lee J,Park S,et al. Pravastatin attenuates acute radiation-induced enteropathy and improves epithelial cell function[J]. Front Pharmacol,2018,9:1215.

[47] Ma CX,Zhao XK,Li YD. New therapeutic insights into radiation-induced myocardial fibrosis[J]. Ther Adv Chronic Dis,2019,10:2040622319868383.

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备注/Memo

备注/Memo:
收稿时间:2019-09-08 基金项目:国家自然科学基金资助项目(81773264) 武汉市中青年医学骨干人才培养工程 通讯作者:江高峰,E-mail:jianggaofeng@wust.edu.cn
更新日期/Last Update: 2020-05-19