[1]邱梦倩 周蕾.心肌标志物在评估特发性炎症性肌病心脏损伤中的价值[J].心血管病学进展,2020,(1):71-74.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.019]
　QIU Mengqian,ZHOU Lei.Value of Myocardial Markers in Evaluating Cardiac Injury in Idiopathic I nflammatory Myopathies[J].Advances in Cardiovascular Diseases,2020,(1):71-74.[doi:10.16806/j.cnki.issn.1004-3934.2020.01.019]
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心肌标志物在评估特发性炎症性肌病心脏损伤中的价值()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2020年1期
页码:
71-74
栏目:
出版日期:
2020-02-04

文章信息/Info

Title:
Value of Myocardial Markers in Evaluating Cardiac Injury in Idiopathic I nflammatory Myopathies
作者:
邱梦倩1 周蕾2
(1.南京医科大学研究生院,江苏 南京210000;2.南京医科大学第一附属医院心血管内科,江苏 南京 210009)
Author(s):
QIU Mengqian1; ZHOU Lei2
(Nanjing Medical University Graduate School,Nanjing 210000,JiangsuChina;2.Department of Cardiology,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210009,Jiangsu,China)
关键词:
心肌标志物; 特发性炎症性肌病; 心脏受累
Keywords:
Myocardial markers;  Idiopathic inflammatory myopathies;  Cardiac injury
DOI:
10.16806/j.cnki.issn.1004-3934.2020.01.019
摘要:
心脏损伤作为特发性炎症性肌病的严重并发症，其检出率不断增加，早期诊断和干预有助于改善患者的临床结局。心肌标志物（肌钙蛋白和传统的肌酸激酶）作为一种便捷、无创的心肌损伤敏感的生物学指标，在评估特发性炎症性肌病患者心脏损伤中的价值尚不明确。现就心肌标志物在特发性炎症性肌病评估中的作用做一综述。
Abstract:
Cardiac injury is a serious complication of idiopathic inflammatory myopathies (IIM) and its detection rate continues to increase.Early diagnosis and intervention can help improve the clinical outcome of patients. Cardiac markers (troponin and traditional creatine kinase) are convenient,sensitive and non-invasive indicators of myocardial damage, however, the value of assessing cardiac injury in patients with IIM remains unclear . This article will review the role of myocardial markers in the evaluation of cardiac involvement in IIM.

参考文献/References:

[1]Sasaki H,Kohsaka H. Current diagnosis and treatment of polymyositis and dermatomyositis[J].Mod Rheumatol,2018,28(6):913-921.

[2]Ernste FC,Reed AM. Idiopathic inflammatory myopathies:current trends in pathogenesis, clinical features, and up-to-date treatment recommendations[J]. Mayo Clin Proc,2013,88(1):83-105.

[3]Oppenheim H. Zur dermatomyositis[J]. Berl Klin Wochenschrift,1899,36:805-807.

[4]Danieli MG,Gelardi C,Guerra F,et al. Cardiac involvement in polymyositis and dermatomyositis[J].Autoimmun Rev,2016,15(5):462-465.

[5]Xiao Y,Zuo X,You Y,et al. Investigation into the cause of mortality in 49 cases of idiopathic inflammatory myopathy:a single center study[J].Exp Ther Med, 2016,11(3):885-889.

[6]中华医学会风湿病学分会.多发性肌炎和皮肌炎诊断及治疗指南[J]．中

华风湿病学杂志,2010,14(12):828-831.

[7]Diederichsen LP,Simonsen JA,Diederichsen AC. Cardiac abnormalities in adult patients with polymyositis or dermatomyositis as assessed by noninvasive modalities[J].Arthritis Care Res(Hoboken),2016,68(7):1012-1020.

[8]汪汉,蔡琳.多发性肌炎/皮肌炎的心脏改变[J].心血管病学进展,2015,36(3):332-337.

[9]Kariyanna PT,Jayarangaiah A,Mahmood A,et al. Rapid progression of heart failure in a patient with idiopathic inflammatory myopathy[J].Am J Med Case Rep,2018,6(8):157-160.

[10]Diederichsen LP. Cardiovascular involvement in myositis[J].Curr Opin Rheumatol, 2017 ,29(6):598-603.

[11]Schwartz T,Diederichsen LP,Lundberg IE,et al. Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies[J]. RMD open,2016,2(2):e000291.

[12]No authors listed. Myocardial infarction redefined — a consensus document of the joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction[J]. Eur Heart J, 2000,21(18):1502-1513.

[13]Alpert JS,Thygesen K,Antman E,et al. Myocardial infarction redefined — a consensus document of the joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction[J]. J Am Coll Cardiol,2000,36:959-969.

[14]Jaffe AS,Ravkilde J,Roberts R,et al. It’s time for a change to a troponin standard[J].Circulation,2000,102(11):1216-1220.

[15]Humphreys JE,Cummins P. Regulatory proteins of the myocardium. Atrial and ventricular tropomyosin and Tn-I in the developing and adult bovine and human hearts[J]. J Mol Cell Cardiol,1984,16:643-657.

[16]Anderson PAW,Malouf NN,Oakeley AE,et al. Troponin T isoform expression in humans: a comparison among normal and failing adult heart, fetal heart and adult and fetal skeletal muscle[J]. Circ Res,1991,69:1226-1233.

[17]Mair, J. Progress in myocardial damage detection: new biochemical markers for clinicians[J]. Crit Rev Clin Lab Sci,1997,34(1):1-66.

[18]Hood D,van Lente F,Estes M. Serum enzyme alterations in chronic muscle disease. A biopsy-based diagnostic assessment[J]. Am J Clin Pathol,1991,95(3):402-407.

[19]Aggarwal R,Lebiedz-Odrobina D,Sinha A,et al. Serum cardiac troponin T, but not troponin I,is elevated in idiopathic inflammatory myopathies[J]. J Rheumatol, 2009 ,36:2711-2714.

[20]Pdw K，Bruekner FE.Nisbet JA,et al．Serum skeletal troponin I in inflammatory muscle disease：relation to creatine kinase ,CKMB and cardiac troponin[J]．Ann Rheum Dis,2000,59(9):750-751.

[21]Rasmussen LH,Madsen HN,Ladefoged SD. Creatine phosphokinase MB and lactate dehydrogenase isoenzyme 1 in polymyositis[J]．Stand J Rheumatol,1985,14(4):427-430．

[22]Babuin L, Jaffe AS . Troponin:the biomarker of choice for the detection of cardiac injury[J]. CMAJ,2005,173(10):1191-1202.

[23]Erlacher P,Lercher A,Falkensammer J,et al. Cardiac troponin and beta-type myosin heavy chain concentrations in patients with polymyositis or dermatomyositis[J]. Clin Chim Acta ,2001,306:27-33.

[24]Cox FM,Delgado V,Verschuuren JJ,et al. The heart in sporadic inclusion body myositis: a study in 51 patients[J]. J Neurol,2010,257(3):447-451.

[25]Park KC,Gaze DC,Collinson PO,et al.Cardiac troponins: from myocardial infarction to chronic disease[J].Cardiovasc Res,2017,113(14):1708-1718.

[26]Fisher C,Agrawal S,Wong WM,et al. Clinical observations on the significance of raised cardiac troponin-T in patients with myositis of varying etiologies seen in rheumatology practice[J].Clin Rheumatol,2010,29(10):1107-1111.

[27]Wens SC ,Schaaf GJ ,Michels M ,et al. Elevated plasma cardiac troponin t levels caused by skeletal muscle damage in pompe disease[J].Circ Cardiovasc Genet,2016,9:6-13.

[28]Lilleker JB,Diederichsen ACP,Jacobsen S,et al. Using serum troponins to screen for cardiac involvement and assess disease activity in the idiopathic inflammatory myopathies[J].Rheumatology(Oxford),2018,57:1041-1046.

[29]Schwarzmeier JD,Hamwi A,Preisel M,et al. Positive troponin T without cardiac involvement in inclusion body myositis[J]. Hum Pathol,2005,36(8):917-921.

[30]Thygesen K,Alpert JS,Jaffe AS,et al. Third universal definition of myocardial infarction[J]. Eur Heart J,2012,33(20):2551-2567.

[31]Dong R,Zhang M,Hu Q,et al.Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review)[J].Int J Mol Med,2018,41:599-614.

[32]Agnello L,Bivona G,Lo Sasso B,et al. Galectin-3 in acute coronary syndrome[J].Clin Biochem,2017,50(13-14):797-803.

[33]López B,González A,Querejeta R,et al. Galectin-3 and histological, molecular and biochemical aspects of myocardial fibrosis in heart failure of hypertensive origin[J]. Eur J Heart Fail,2015,17(4):385-392.

[34]Gehlken C,Suthahar N,Meijers WC,et al. Galectin-3 in heart failure: an update of the last 3 years[J]. Heart Fail Clin,2018,14(1):75-92.

[35]Ho JE,Liu C,Lyass A,et al. Galectin-3,a marker of cardiac fibrosis,predicts incident heart failure in the community[J].J Am Coll Cardiol,2012,60(14):1249-1256.

[36]de Boer RA,van Veldhuisen DJ,Gansevoort RT,et al. The fibrosis marker galectin-3 and outcome in the general population[J].J Intern Med,2012,272(1):55-64.

[37]Lim Y,Lee DY,Lee S,et al. Identification of autoantibodies associated with systemic lupus erythematosus[J]. Biochem Biophys Res Commun,2002,295(1):119-124.

[38]Dhir T ,Jiang N . Misleading elevation of troponin T caused by polymyositis[J].Int J Biomed Sci,2013,9(2):107-111.

[39]Michael H, James BL, Ariane LH, et al.Cardiac troponin testing in idiopathic inflammatory myopathies and systemic sclerosis-spectrum disorders: biomarkers to distinguish between primary cardiac involvement and low-grade skeletal muscle disease activity[J].Ann Rheum Dis,2015,74:795-798.

[40]Chen F, Peng Y, Chen M . Diagnostic approach to cardiac involvement in idiopathic inflammatory myopathies.A strategy combining cardiac troponin I but not T assay with other methods[J].Int Heart J,2018;59:256-262

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金面上项目（81570332）；医学重点人才（ZDRCA2016019）
更新日期/Last Update: 2020-03-24