[1]李莎 熊峰.胰岛素抵抗与心血管疾病研究进展[J].心血管病学进展,2019,(9):1307-1311.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.032]
 Li ShaXiong Feng.Insulin Resistance and Cardiovascular Diseases[J].Advances in Cardiovascular Diseases,2019,(9):1307-1311.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.032]
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胰岛素抵抗与心血管疾病研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年9期
页码:
1307-1311
栏目:
综述
出版日期:
2019-12-25

文章信息/Info

Title:
Insulin Resistance and Cardiovascular Diseases
作者:
李莎 熊峰
(西南交通大学医学院,西南交通大学附属医院,成都市第三人民医院,四川 成都,610036)
Author(s):
Li ShaXiong Feng
(Southwest Jiaotong University College of Medicine,The Affiliated Hospital of Southwest Jiaotong University,The Third?Peoples Hospital of Chengdu,Chengdu 610036,Sichuan,China)
关键词:
胰岛素抵抗高胰岛素血症心血管疾病
Keywords:
Insulin resistanceHyperinsulinemiaCardiovascular diseases
DOI:
10.16806/j.cnki.issn.1004-3934.2019.09.032
摘要:
胰岛素抵抗是2型糖尿病主要发病机制之一,近年研究显示,胰岛素抵抗与机体炎症、氧化应激、microRNA表达、胰岛素代谢信号通路异常、线粒体功能障碍等多种因素有关,并且是构成高血压、血管钙化、冠心病、心肌病、心功能不全、脂代谢异常等的危险因素。对胰岛素抵抗在心血管疾病发生发展中的研究,能为2型糖尿病伴心血管疾病防治靶点前移提供新思路。
Abstract:
Insulin resistance (IR) is one of the main pathogenesis of type 2 diabetes mellitus. Recent studies have shown that IR is also related to inflammation, oxidative stress, expression of microRNAs, abnormal insulin metabolic signaling pathway, mitochondrial dysfunction and other factors. All kinds of reasons constitute risk factors such as hypertension, vascular calcification, coronary heart disease, cardiomyopathy, cardiac insufficiency and abnormal lipid metabolism. The study of IR in the occurrence and development of cardiovascular diseases can provide new ideas for the prevention and treatment of type 2 diabetes mellitus with cardiovascular diseases

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更新日期/Last Update: 2020-02-06