[1]薛万腾 吕志慧 高向向 黄帅 王营忠.RhoA/ROCK信号通路与心肌梗死关系的研究进展[J].心血管病学进展,2019,(9):1282-1285.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.025]
 XUE Wanteng,LV Zhihui,GAO Xiangxiang,et al.RhoA/ROCK Signaliing Pathway in Myocardial Infarction[J].Advances in Cardiovascular Diseases,2019,(9):1282-1285.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.025]
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RhoA/ROCK信号通路与心肌梗死关系的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年9期
页码:
1282-1285
栏目:
综述
出版日期:
2019-12-25

文章信息/Info

Title:
RhoA/ROCK Signaliing Pathway in Myocardial Infarction
作者:
薛万腾 吕志慧 高向向 黄帅 王营忠
 (延安大学附属医院,陕西 延安 716000 )
Author(s):
XUE WantengLV ZhihuiGAO XiangxiangHUANG ShuaiWANG Yingzhong
(The Affiliated Hospital of Yan’an UniversityYan’an 716000 ShaanxiChina)
关键词:
RhoA/ROCK信号通路心肌梗死 ROCK抑制剂
Keywords:
RhoA/ROCK signaling pathway Myocardial infarction ROCK inhibitors
DOI:
10.16806/j.cnki.issn.1004-3934.2019.09.025
摘要:
心肌梗死是心血管疾病死亡的主要原因。其发病机制尚未完全阐明,研究发现RhoA/ROCK信号通路在内皮功能障碍、炎症反应、氧化应激、内质网应激、细胞凋亡等过程中起关键作用,与心肌梗死的发生、发展紧密相关。ROCK抑制剂也为心肌梗死的治疗提供一条新思路。现就近年RhoA/ROCK信号通路在心肌梗死中的发病机制做一综述。
Abstract:
Myocardial infarction is the main cause of death from Cardiovascular disease. Its pathogenesis has not been fully elucidated.The research found that RhoA/ROCK signaling pathway is related to the occurrence and development of myocardial infarction in endothelial dysfunction, inflammatory response, oxidative stress, endoplasmic reticulum stress, cell apoptosis. Futhermore ROCK inhibitor display a new approach for the treatment of myocardial infarction.This article reviews the pathogenesis of RhoA/ROCK signaling pathway in myocardial infarction

参考文献/References:


[1] Govek EE, Newey SE, van Aelst L. The role of the Rho GTPases inneuronal development[J]. Genes Dev, 2005, 19(1):1-49.

[2] Zhang B, Zhang Y, Shacter E, et al. Mechanism of the guanine nucleotideexchange reaction of Ras GTPase--evidence for a GTP/GDP displacementmodel[J]. Biochemistry, 2005,44(7):2566-2576.

[3] Ruihua H,Mengyi Z,Chong Z,et al. RhoA regulatesresistance to irinotecan by regulating membrane transporterand apoptosis signaling in colorectal cancer[J]. Oncotarget,2017,7(52) :87136-87146.

[4] Wada N,Liao JK.Rho/Rho-associated coiled-coil formingkinase pathway as therapeutic targets for statins inatherosclerosis[J].Antioxid Redox Signal,2014,20(8):1251-1267.

[5] Mishra RK,Alokam R,Sriram D,et al.Potential role of Rho kinasnase inhibitors incombating diabetes-re-late complications including diabetic neuropathy-are-view[J].Curr Diabetes Rev,2013,9(3):249-266.

[6] Noma K, Oyama N, Liao JK. Physiological role of ROCKs in thecardiovascular system[J]. Am J Physiol Cell Physiol,2006,290(3):C661-C668.

[7] Cicek FA,Kandilci HB,Turan B.Role of ROCK upregulation in?endothelial?and smooth muscle?vascular?functions in diabetic rat aorta[J].Cardiovasc Diabetol,2013,12:51.

[8] Lee TM,Lin SZ,Chang NC.Nicorandil regulates the macrophage skewing and amelioratesmyo?broblasts by inhibition of RhoA/Rho-kinase signalling ininfarcted rats[J].Cell Mol Med,2018,22(2):1056-1069.

[9] Zeng P,Pi RB,Li P,et al. Fasudil hydrochloride,a potent ROCK inhibitor,inhibits corneal neovascularization afteralkali burns in mice[J].Mol Vis,2015,21:688-698.

[10] Zhu X,Zong G,Zhu L,et al.Deletion of class A scavenger?receptor?deteriorates obesity-induced insulin resistance in adipose tissue[J].Diabetes,2014,63(2):562-577.

[11] Yang L,Dai F,Tang L,et al.Macrophage differentiation induced by PMA is mediated by?activation?of?RhoA/ROCK?signaling[J].Toxicol Sci,2017,42(6):763-771.

[12] Shimokawa H,Satoh K.Vascular?function[J].Arterioscler Thromb Vasc Biol,2014,34(11):2359-2362.

[13] Yee HF, Melton AC, Tran BN.RhoA rho-associated kinase mediatesfibroblast contractile force generation[J].Biochem Biophys Res Commun,2001, 280(5):1340-1345.

[14] Vanhoutte PM,Zhao Y,Xu A,et al.Thirty years of saying NO: sources,fate,actions,and misfortunes of the endothelium-derived vasodilator mediator[J].Circ Res,2016,119(2):375-396.

[15] Tang L,Dai F,Liu Y,et al. RhoA/ROCK signaling regulates smooth muscle phenotypic modulation and vascular remodeling via?the JNK pathway and vimentin cytoskeleton[J].Pharmacol Res,2018,133:201-212.

[16] Mozzini C,Cominacini L,Garbin U,et al.Endoplasmic reticulum stress, NRF2 signalling and cardiovascular diseases in a nutshell[J].Curr Atheroscler Rep,2017,19(8):33.

[17] Dong JJ,Lu XC,Liu XH,et al.Effects of?sarcoplasmic reticulum?calcium ATPase?2a overexpression on?endoplasmic reticulum stress?in cardiomyocytes[J].Zhonghua Yi Xue Za Zhi,2009,89(6):415-418.

[18] Li Y,Zhu W,Tao J,et al. Fasudil protects the heart against is-chemia-reperfusion injury by attenuating endoplasmic reticulumstress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways[J].PloS One,2012,7(10) :e48115.

[19] Wolfrum S,Dendorfer A,Rikitake Y,et al.Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular?protection[J].Arterioscler Thromb Vasc Biol,?2004,24(10):1842-1847.

[20] Hung MJ,Hu P,Hung MY.Coronary artery spasm:review and update[J].Int J Med Sci,2014,11(11):1161-1171.

[21] Que CX,Yu YJ,Chen H,et al.Research progress and forensic application on the pathogenesis of coronary artery spasm[J].Fa Yi Xue Za Zhi,2018,34(1):60-66. 1004-5619.

[22] Akbar H,Duan X,Saleem S,et al.Rho A and Rac1 GTPases differentially regulate agonist-receptor mediated reactiveoxygen species generation in platelets[J]. PLoS One,2016,11(9) :e0163227.

[23] Satoh K.Cyclophilin A in cardiovascular homeostasis anddiseases[J].Tohoku J Exp Med,2015,235(1):1-15.

[24] Radi E,Formichi P,Battisti C,et al. Apoptosis andoxidative stress in neurodegenerative diseases[J].J Alzheimers Dis,2014,42(Suppl 3):S125-S152.

[25] Moris D,Spartalis M,Tzatzaki E, et al. The role of reactive oxygen species in myocardial redox signaling and regulation[J].Ann Transl Med,?2017,5(16):324.

[26] Satoh K,Fukumoto Y,Shimokawa H.Rho-kinase: important newtherapeutic target in Cardiovascular diseases[J].Am J Physiol HeartCirc Physiol,2011,301(2):H287-296.

[27] Christian F,Smith EL,Carmody RJ.The regulation of?NF-κB subunits by phosphorylation[J].Cells,2016,5(1):1-12.

[28] Huang L,Li Q,Wen R,et al.Rho-kinase inhibitorprevents acute injury against transient focal cerebralischemia by enhancing the expression and function ofGABA receptors in rats[J].Eur J Pharmacol,2017,797:134-142.

[29] Del Re DP,Miyamoto S,Brown JH.Focal adhesion kinase as a?RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte?protection[J].J Biol Chem,?2008,283(51):35622-35629.

[30] Brand CS,Tan VP,Brown JH,et al.RhoA regulates Drp1 mediated mitochondrial fission through ROCK to protect cardiomyocytes[J].Cell Signal,2018,50:48-57.

[31] Ye H,Zhang G,Cao R,et al.Fasudil?attenuates?mitochondrial?injury?and?apoptosis?in?rat?model?of?myocardialischemia/reperfusion?injury[J].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi,2017,33(7):909-914.

[32] Amin F,Ahmad A,Feroz A,et al.An update on the association of protein kinases with?cardiovascular diseases[J].Curr Pharm Des,?2019,25(2):174-183.

[33] Shimokawa H,Satoh K.2015 ATVB Plenary Lecture: translational research on rho-kinase in cardiovascular medicine[J].Arterioscler Thromb Vasc Biol,2015,35(8):1756-1769.

更新日期/Last Update: 2020-02-06