[1]程宏基 黄裕立 黄伟俊 李美君 童辉煜 申常造 谭宽 蔡福生 胡允兆.入院血糖水平不同的分组方法对急性心力衰竭患者远期预后影响的比较[J].心血管病学进展,2019,(9):1323-1329.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.035]
　CHENG Hongji,HUANG Yuli,HUANG Weijun,et al.Effect of Different Admission Blood Glucose Grouping Methods on the Prognosis of Acute Heart Failure Patients[J].Advances in Cardiovascular Diseases,2019,(9):1323-1329.[doi:10.16806/j.cnki.issn.1004-3934.2019.09.035]
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入院血糖水平不同的分组方法对急性心力衰竭患者远期预后影响的比较()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年9期
页码:
1323-1329
栏目:
论著
出版日期:
2019-12-25

文章信息/Info

Title:
Effect of Different Admission Blood Glucose Grouping Methods on the Prognosis of Acute Heart Failure Patients
作者:
程宏基1 黄裕立2 黄伟俊2 李美君2 童辉煜2 申常造2 谭宽2 蔡福生2 胡允兆2
(1. 广州市番禺区何贤纪念医院心内科,广东 广州 511400 ;2. 南方医科大学顺德医院心内科,广东 佛山 528300 )
Author(s):
CHENG Hongji1;  HUANG Yuli2;  HUANG Weijun2;  LI Meijun2;  TONG Huiyu2;  SHEN Changzao2;  TAN Kuan2;  CAI Fusheng2;  HU Yunzhao2
(1.Department of Cardiology, Panyu District He Xian Memorial Hospital,Guangzhou 511400, Guangdong, China; 2. Department of Cardiology, Shunde Hospital of Southern Medical University , Foshan 528300, Guangdong, China )
关键词:
急性心力衰竭; 入院血糖; 分组方法; 死亡率; 预后
Keywords:
Acute heart failure;  Admission blood glucose;  Grouping method;  Mortality;  Prognosis
DOI:
10.16806/j.cnki.issn.1004-3934.2019.09.035
摘要:
目的 探讨不同入院血糖（AG）分组方法对急性心力衰竭（AHF）患者预后的影响是否存在差异。方法 连续纳入2012年6月—2016年12月因AHF住院的512例患者。对患者进行回顾性研究，按AG水平分别采用二分法和四分法对患者进行分组，比较分析不同分组方法对AG水平与患者1年死亡率关系的影响，并比较不同血糖水平Cox模型在不同分组方法中的差异。从而探讨采用不同方法对AG进行分组对AHF患者预后的影响是否存在差异。结果 中位随访时间20.2个月的随访，随访率84.0%（430例）。单因素分析对比：以血糖中值为切点把患者分为血糖正常组（AG≤7.53 mmol/L）及血糖升高组（AG＞7.53 mmol/L）两组，两组间1年死亡率无差异。AHF患者采用四分法分为四组（F1组≤5.76 mmol/L、F2组5.77~7.53 mmol/L、F3组7.54~9.81 mmol/L、F4组＞9.81 mmol/L），四组间1年死亡率无组间差异（P＞0.05）；四组间的长期预后无差异（log-rank P=0.884）。单因素Cox比例风险模型分析对比：年龄、AHF史、脑卒中、心源性休克、收缩压、血钠、C反应蛋白、白蛋白是AHF患者全因死亡的独立预测因素。四分法各组分析均未提示AG是AHF患者全因死亡的独立预测因素。多因素Cox比例风险模型分析对比：二分法及四分法均未提示AG是AHF患者全因死亡的危险因素或预测因子。 结论 二分法和四分法分组的AG水平与远期死亡率无显著关系，同时AG不是AHF患者全因死亡的危险因素或预测因子。
Abstract:
Objective To compare the effect of different admission glucose (AG) grouping methods on the prognosis of acute heart failure (AHF) patients. Methods The AHF patients included in the first part (512 cases) were d ivided into?four?groups?by?using?the?quartile method?of?AG?level. To compare and analyze the association between the AG levels and the 1-year mortality under this grouping method. The differences in COX models with different AG levels were compared. Then the two groups used in the first part were compared directly with those in the quartile method. Results (i)The univariate analysis showed: AHF patients were divided into four groups (F1≤5.76 mmol/L, F2:5.77~7.53 mmol/L, F3:7.54~9.81 mmol/L, F4>9.81 mmol/L) using quartile method. Among the four groups, there were no differences in hospitalization and the 1-year mortality (P>0.05). There was no difference in the long-term prognosis between the four groups (Log-rank P= 0.884).?(ii)Neither univariate regression nor multivariate regression analysis showed that AG was a risk factor or predictor of all-cause death in AHF patients. Conclusions We found no significant association between AG level and long-term mortality in different grouping methods, and AG was not a risk factor or predictor of all-cause death in AHF patients

参考文献/References:

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更新日期/Last Update: 2020-02-06