[1]娄奇,李为民.CaV1.2在心律失常中作用的研究进展[J].心血管病学进展,2019,(6):919-923.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.020]
 LOU Qi,LI Weimin.CaV1.2 in Arrhythmias[J].Advances in Cardiovascular Diseases,2019,(6):919-923.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.020]
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CaV1.2在心律失常中作用的研究进展(/HTML)
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年6期
页码:
919-923
栏目:
综述
出版日期:
2019-09-25

文章信息/Info

Title:
CaV1.2 in Arrhythmias
作者:
娄奇李为民
(1.哈尔滨医科大学研究生院,哈尔滨 黑龙江 150001 ; 2. 哈尔滨医科大学附属第一医院 心内科,哈尔滨 黑龙江 150001 )
Author(s):
LOU Qi 1 LI Weimin 2
(1.Graduate School of Harbin Medical University, Harbin 150001,Heilongjiang,China; 2. Department of Cardiology,The First Affiliated Hospital of Harbin Medical University, Harbin 150001,Heilongjiang,China)
关键词:
L型钙通道CaV1.2心律失常
Keywords:
L-type calcium channel CaV1.2 Arrhythmias
DOI:
10.16806/j.cnki.issn.1004-3934.2019.06.020
摘要:
心律失常的发生机制复杂,且临床上应用于治疗心律失常的药物治疗效果不佳。近年来很多研究发现L型钙通道的异常与心律失常密切相关。CaV1.2为心肌中L型钙离子通道的主要亚型,近期研究发现CaV1.2蛋白及mRNA表达异常与心律失常的发生发展密切相关,并且CaV1.2相关的治疗心律失常的药物在心律失常中治疗效果显著,因此CaV1.2有望作为治疗心律失常的新靶点。现重点介绍通过干预CaV1.2治疗心房颤动,长QT间期综合征以及Brugada综合征等心律失常的最新研究进展。
Abstract:
The pathogenesis of arrhythmia is complex and the therapeutic effect of drug for arrhythmia is not well. In recent years, many studies have found that abnormal L-type calcium channels are closely related to the occurrence and development of a variety of arrhythmias. CaV1.2 is the main subtype of L-type calcium channel in myocardium. Recent studies have found that abnormal expression of CaV1.2 is closely related to the occurrence and development of a variety of arrhythmias, and drugs related to CaV1.2 for arrhythmia have significant therapeutic effects. Therefore, CaV1.2 is expected to be a new target for arrhythmia’s treatment. This article focuses on the latest research progress in interventing CaV1.2 for atrial fibrillation, long QT interval syndrome and Brugada syndrome.

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备注/Memo

备注/Memo:
基金项目:哈尔滨高层次人才基金(2013SYYRCYJ06) 收稿日期:2019-03-21
通讯作者:李为民,E-mail:liweimin_2009@163.com
更新日期/Last Update: 2019-12-16