[1]王振伟,王涟.Loeffler心内膜炎的研究进展[J].心血管病学进展,2019,(6):915-918.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.019]
　WANG Zhenwei,WANG Lian.Loeffler Endocarditis[J].Advances in Cardiovascular Diseases,2019,(6):915-918.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.019]
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年6期
页码:
915-918
栏目:
综述
出版日期:
2019-09-25

文章信息/Info

Title:
Loeffler Endocarditis
作者:
王振伟; 王涟
(南京大学医学院附属鼓楼医院心血管内科,江苏 南京210008)
Author(s):
WANG Zhenwei; WANG Lian
(Department of Cardiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu,China)
关键词:
Loeffler心内膜炎; 嗜酸性粒细胞性心内膜炎; 嗜酸性粒细胞增多症
Keywords:
Loeffler endocarditis;  Eosinophilic endocarditis;  Eosinophilia
DOI:
10.16806/j.cnki.issn.1004-3934.2019.06.019
摘要:
Loeffler心内膜炎是嗜酸性粒细胞增多症主要的并发症，病因及临床表现多种多样，病理生理机制主要为嗜酸性粒细胞脱颗粒造成的直接或间接的心脏毒性作用。Loeffler心内膜炎一般分为急性炎性坏死期、血栓形成期及纤维化期三个阶段，其诊断方法复杂多样，容易误诊，目前心内膜心肌活组织检查为诊断金标准。Loeffler心内膜炎若治疗及时，一般预后良好。现重点对Loeffler心内膜炎的病因、病理生理学机制、分期、治疗与管理等方面进行阐述。
Abstract:
Loeffler endocarditis is a major complication of eosinophilia. Its etiology and clinical manifestations are diverse. The pathophysiological mechanism is mainly direct or indirect cardiotoxicity caused by eosinophil degranulation. Loeffler endocarditis is generally divided into three stages:acute inflammatory necrosis, thrombosis and fibrosis. The diagnosis method is complex and diverse, and it is easy to be misdiagnosed. At present, endomyocardial biopsy is the gold standard for diagnosis. If Loeffler endocarditis is treated promptly, the general prognosis is good. This article mainly focuses on the etiology, pathophysiological mechanism, staging, treatment and management of Loeffler endocarditis.

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备注/Memo

备注/Memo:
通讯作者：王涟，E-mail：wanglianglyy@163.com?收稿日期：2019-03-05
更新日期/Last Update: 2019-12-16