[1]程晓艺,寇秀玲,黄明刚,等.颈动脉斑块与冠状动脉粥样硬化相关性影像学分析[J].心血管病学进展,2019,(6):960-966.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.030]
　CHENG Xiaoyi,KOU Xiuling,HUANG Minggang,et al.Imaging Analysis of Carotid Plaque and Coronary Artery Atherosclerosis[J].Advances in Cardiovascular Diseases,2019,(6):960-966.[doi:10.16806/j.cnki.issn.1004-3934.2019.06.030]
点击复制

颈动脉斑块与冠状动脉粥样硬化相关性影像学分析()
分享到：

《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年6期
页码:
960-966
栏目:
论著
出版日期:
2019-09-25

文章信息/Info

Title:
Imaging Analysis of Carotid Plaque and Coronary Artery Atherosclerosis
作者:
程晓艺1;  寇秀玲1;  黄明刚1; 常小妮2; 李芝林3
(1. 西安医学院 陕西省人民医院影像科,陕西 西安 710068 ;2. 陕西省人民医院超声科,陕西 西安 710068 ;3. 中国人民解放军63755部队,新疆 喀什 844000 )
Author(s):
CHENG Xiaoyi1;  KOU Xiuling1;  HUANG Minggang1;  CHANG Xiaoni2;  LI Zhilin3
(Department of Radiology, Shaanxi Provincial Peoples Hospital, Xian Medical University, Xian 710068, Shaanxi, China; 2. Department of Ultrasound, Shaanxi Provincial Peoples Hospital, Xian 710068, Shaanxi, China; 3. Peoples Liberation Army 63 755 Troops, Kashgar 844000, Xinjiang, China)
关键词:
颈动脉斑块; 冠状动脉粥样硬化; 年龄; 性别; 危险因素
Keywords:
Carotid plaque; Coronary atherosclerosis; Age; Gender; Risk factors
DOI:
10.16806/j.cnki.issn.1004-3934.2019.06.030
摘要:
目的 研究颈动脉斑块与不同类型冠状动脉斑块之间的相关性。方法 收集2018年3月—2018年9月接诊的临床怀疑有心血管疾病的患者行640层冠状动脉CT成像，并于两周内行颈动脉超声检查。分别记录每位患者640层冠状动脉CT显示的斑块情况及二维彩色多普勒超声所显示的颈动脉斑块类型，用Logistic线性回归对收集的数据进行分析。结果 颈动脉低回声斑块与冠状动脉非钙化斑块总数、颈动脉混合回声斑块与冠状动脉非钙化斑块总数及混合斑块总数、颈动脉强回声斑块与不同类型冠状动脉斑块总数之间均具有统计学意义（P＜0.05），其中颈动脉低回声斑块与冠状动脉非钙化斑块关系更密切（B=0.353，Exp（B）=1.423，P=0.019），颈动脉混合回声斑块与冠状动脉混合斑块关系最密切（B=0.620，Exp（B）=1.929，P＜0.001），颈动脉强回声斑块与冠状动脉钙化斑块关系更密切（B=1.443，Exp（B）=4.232，P＜0.001）。另外，年龄越小、男性患者颈动脉低回声斑块与冠状动脉非钙化斑块关系更显著（B=0.432，Exp（B）=1.540，P=0.025）。危险因素在斑块进展中的作用不容忽视。随着年龄的增长，颈动脉混合回声斑块与冠状动脉混合斑块总数的相关性在性别方面无明显差异（男：B=0.677、Exp（B）=1.968，女：B=0.675、Exp（B）=1.964）；颈动脉强回声斑块与冠状动脉钙化斑块总数关系在女性中更明显（B=1.927，Exp（B）=6.867，P＜0.001）。结论 颈动脉斑块与不同类型冠状动脉粥样硬化斑块之间具有显著相关性，且应重视在年龄与性别方面的差异。另外危险因素在疾病进展中的作用亦不可小觑。
Abstract:
Objective To study the correlation between carotid plaque and different types of coronary artery plaques. Methods A 640-slice coronary CT scan was performed in patients with clinically suspected cardiovascular diseases from March 2018 to September 2018, and carotid ultrasound was performed within 2 weeks. The plaques of 640-slice coronary CT and the types of carotid plaques displayed by two-dimensional color Doppler ultrasound were recorded for each patient,and the collected data were analyzed by linear regression. Results The relationship between carotid hypoechoic plaques and coronary non-calcified plaque score,carotid mixed echo plaques and coronary non-calcified plaque score with mixed plaque score,carotid strong echogenic plaques and coronary each type of plaque score were found（P＜0.05），in which carotid hypoechoic plaques were more closely related to coronary non-calcified plaque score [B=0.353，Exp(B)=1.423，P=0.019]，carotid mixed echo plaques and coronary mixed plaques were displays higher statistically significant [B=0.620，Exp(B)=1.929，P＜0.001]，carotid strong echogenic plaques were showed highest connection with coronary calcified plaque score[B=1.443，Exp(B)=4.232，P＜0.001]. In addition, the younger the age, the more carotid hypoechoic plaques were associated with coronary non-calcified plaques[B=0.432，Exp(B)=1.540，P=0.025]. The role of risk factors can not be ignored.With age, there was no significant difference in gender between carotid mixed echo plaques and coronary mixed plaque score[B=0.677，Exp(B)=1.968(male),B=0.675，Exp(B)=1.964(female)]; the relationship between carotid strong echogenic plaques and coronary calcified plaque score was more pronounced in women[B=1.927，Exp(B)=6.867，P＜0.001). Conclusion Carotid plaque is obviously associated with different types of coronary atherosclerotic plaque, and attention should be paid to age and gender differences.Simultaneously,the role of risk factors in disease progression should never be underestimated.

参考文献/References:

[1].Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030[J].PLoS Med,2006,3(11):e442.
[2].Cappelletti A,Astore D,Godino C,et al. Relationship between Syntax Score and prognostic localization of coronary artery lesions with conventional risk factors, plasma profile markers,and carotid atherosclerosis (CAPP Study 2)[J].Int J Cardiol,2018,257(3):306-311.
[3].赵倩,吴新淮,蔡剑鸣,等.冠状动脉与颈动脉粥样硬化斑块成分的相关性分析[J].实用放射学杂志,2013,29(5):743-747.
[4].Pundziute G,Schuijf JD,Jukema JW,et al. Evaluation of plaque characteristics in acute coronary syndromes:non-invasive assessment with multi-slice computed tomography and invasive evaluation with intravascular ultrasound radiofrequency data analysis[J]. Eur Heart J,2008,29(19):2373-2381.
[5].Touboul PJ,Hennerici MG,Meairs S,et al.Mannheim carotid intima-media thickness and plaque consensus(2004–2006–2011)[J].Cerebrovasc Dis,2012,34(4):290-296.
[6].Guaricci AI,Pontone G,Fusini L,et al.Additional value of inflammatory biomarkers and carotid artery disease in prediction of significant coronary artery disease as assessed by coronary computed tomography angiography[J]. Eur Heart J Card Imaging,2016,18(9):1049-1056.
[7].许兵,路鹤晴,田冰,等.320排CT容积扫描法与螺旋扫描法在低心率冠状动脉成像中的对比研究[J].第二军医大学学报,2014,35(7):796-799.
[8].American Heart Association Committee Report. A reporting system on patients evaluated for coronary artery disease[J].Circulation,1999,51(1):7-34.
[9].中华放射学杂志心脏冠状动脉多排CT临床应用协作组.心脏冠状动脉多排CT临床应用专家共识[J]. 中华放射学杂志,2011,45(1):9-17.
[10].Alexopoulos N,McLean DS,Janik M,et al. Epicardial adipose tissue and coronary artery plaque characteristics[J]. Atherosclerosis,2010,210(1):150-154.
[11].Lin F,Shaw LJ,Berman DS,et al. Multidetector computed tomography coronary artery plaque predictors of stress-induced myocardial ischemia by SPECT[J]. Atherosclerosis,2008,197(2):700-709.
[12].Hodis HN,Mack WJ,LaBree L,et al. The role of carotid arterial intima-media thickness in predicting clinical coronary events[J]. Ann Intern Med,1998,128(4):262-269.
[13].陈伟伟,高润霖,刘力生,等.《中国心血管病报告2017》概要[J].中国循环杂志,2018,33(1):1-8.
[14]. Sreckovic B,Sreckovic VD,Soldatovic I,et al. Homocysteine is a marker for metabolic syndrome and atherosclerosis[J]. Diabetes Metab Syndr, 2017,11(3):179-182.
[15]. Small GR,Chow BJW. CT imaging of the vulnerable plaque[J]. Curr Treat Option Cardiovasc Med,2017,92(19):2-7.
[16].葛均波,徐永健. 内科学[M]. 北京:人民卫生出版社,2013:222-223.
[17].Wu N,Chen X,Li M,et al. Predicting obstructive coronary artery disease using carotid ultrasound parameters:a nomogram from a large real -world clinical data[J]. Eur J Clin Invest,2018,48(8):e12956.
[18].Dalager S,Paaske WP,Bayer Kristensen I,et al. Artery-related differences in atherosclerosis expression:implications for atherogenesis and dynamics in intima-media thickness[J]. Stroke,2007,38(10):2698-2705.
[19].Nighoghossian N,Derex L,Douek P. The vulnerable carotid artery plaque:current imaging methods and new perspectives[J]. Stroke,2005,36(12):2764-2772.
[20].Gohar A. Cardiovascular disease in men and women:different but equal[D]. Netherlands:Utrecht University,2018.
[21].Clarkson TB. Estrogen effects on arteries vary with stage of reproductive life and extent of subclinical atherosclerosis progression[J].Menopause,2018,25(11):1262-1274.
[22].赵心,白小涓,汉雯,等.绝经后女性雌激素水平与骨质疏松症和动脉粥样硬化风险相关性研究[J].中华高血压杂志,2018,26(3):300-300.

相似文献/References:

[1]韩月 朱莉 宋桂仙.白介素-12家族在冠状动脉粥样硬化中的研究进展[J].心血管病学进展,2020,(5):508.[doi:10.16806/j.cnki.issn.1004-3934.20.05.016]
　HAN Yue,ZHU Li,SONG Guixian.Interleukin-12 Family in Coronary Atherosclerosis[J].Advances in Cardiovascular Diseases,2020,(6):508.[doi:10.16806/j.cnki.issn.1004-3934.20.05.016]
[2]梁春晓 李爽 刘莹 余建群.不同区域的心包脂肪容积与心血管危险因素及冠状动脉粥样硬化的关系[J].心血管病学进展,2020,(8):873.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.022]
　LIANG Chunxiao,LI Shuang,LIU Ying,et al.Epicardial, Paracardial and Pericardial Fat Volume by CCTA: Relationship with Cardiovascular Risk Factors and Coronary Atherosclerosis[J].Advances in Cardiovascular Diseases,2020,(6):873.[doi:10.16806/j.cnki.issn.1004-3934.2020.08.022]
[3]李爽 梁春晓 方鑫 刘莹 余建群.心包内脂肪容积对糖尿病及非糖尿病患者冠状动脉粥样硬化影响的CT评价[J].心血管病学进展,2020,(9):972.[doi:10.16806/j.cnki.issn.1004-3934.2020.09.021]
　LI Shuang,LIANG Chunxiao,FANG Xin,et al.Effect of Epicardial Adipose Tissue Volume by CCTA on Coronary Atherosclerosis in Patients with or without Type 2 Diabetes Mellitus[J].Advances in Cardiovascular Diseases,2020,(6):972.[doi:10.16806/j.cnki.issn.1004-3934.2020.09.021]
[4]王 西,王 萍.大动脉炎加速冠状动脉粥样硬化机制的研究进展[J].心血管病学进展,2022,(2):154.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.015]
　WANG XiWANG Ping.Mechanism of Accelerated Atherosclerosis in Takayasu Arteritis[J].Advances in Cardiovascular Diseases,2022,(6):154.[doi:10.16806/j.cnki.issn.1004-3934.2022.02.015]
[5]谭思华 周晓莉.非酒精性脂肪肝与冠状动脉粥样硬化及炎症的研究进展[J].心血管病学进展,2023,(5):439.[doi:10.16806/j.cnki.issn.1004-3934.2023.05.013]
　TAN Sihua,ZHOU Xiaoli.Association of Non-Alcoholic Fatty Liver Disease with Coronary Atherosclerosis and Inflammation[J].Advances in Cardiovascular Diseases,2023,(6):439.[doi:10.16806/j.cnki.issn.1004-3934.2023.05.013]
[6]韩冰 来春林.黑色素瘤缺乏因子2炎症小体在心血管疾病中的研究进展[J].心血管病学进展,2023,(11):986.[doi:10.16806/j.cnki.issn.1004-3934.2023.11.007]
　HAN Bing,LAI Chunlin.Absent In Melanoma 2 Inflammasome in Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2023,(6):986.[doi:10.16806/j.cnki.issn.1004-3934.2023.11.007]

备注/Memo

备注/Memo:
通讯作者：黄明刚，E-mail: mg.huang@163.com?收稿日期：2019-01-21
更新日期/Last Update: 2019-12-17