[1]何燕 刘育.C型利钠肽与心力衰竭[J].心血管病学进展,2019,(5):745-748.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.020]
 HE Yan,LIU Yu.C-type Natriuretic Peptide and Heart Failure[J].Advances in Cardiovascular Diseases,2019,(5):745-748.[doi:10.16806/j.cnki.issn.1004-3934.2019.05.020]
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C型利钠肽与心力衰竭()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2019年5期
页码:
745-748
栏目:
综述
出版日期:
2019-08-25

文章信息/Info

Title:
C-type Natriuretic Peptide and Heart Failure
作者:
何燕 刘育
(武汉大学人民医院心内科 武汉大学心血管病研究所 心血管病湖北省重点实验室,湖北 武汉 430060)
Author(s):
HE Yan LIU Yu
(Department of CardiologyRenmin Hospital of Wuhan UniversityHubei Key Laboratory of Cardiovascular DiseasesInstitute of Cardiovascular DiseaseWuhan UniversityWuhan 430060HubeiChina)
关键词:
心血管病学C型利钠肽利钠肽受体B心力衰竭
Keywords:
Cardiovascular diseaseC-type natriuretic peptideNatriuretic peptide receptor BHeart failure
DOI:
10.16806/j.cnki.issn.1004-3934.2019.05.020
摘要:
C型利钠肽是利钠肽家族中的一员,高度保守,分布广泛,与心房利钠肽和脑利钠肽具有相似的结构和生理特性。C型利钠肽主要和利钠肽受体B结合,通过抗纤维化、抗过度增殖、抗过度肥大、抗炎症等生理效应在心血管疾病中发挥作用。心力衰竭时体内C型利钠肽的变化对疾病有预测意义,外源性C型利钠肽通过改善心脏功能对心力衰竭心脏起保护性作用。现就C型利钠肽的特征及其与心力衰竭的关系做一综述。
Abstract:
C-type natriuretic peptide is a member of natriuretic peptide family, highly conserved and widely distributed. It has similar structure and physiological characteristics with atrial natriuretic peptide and brain natriuretic peptide. C-type natriuretic peptide mainly binds to natriuretic peptide receptor B, and plays a role in cardiovascular diseases through anti-fibrosis, anti-excessive proliferation, anti-excessive hypertrophy, anti-inflammation and other physiological effects. Changes of C-type natriuretic peptide in vivo during heart failure have predictive significance for the disease. Exogenous c-type natriuretic peptide plays a protective role on the heart in heart failure by improving cardiac function. This article reviews the characteristics of C-type natriuretic peptide and its relationship with heart failure.

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更新日期/Last Update: 2019-12-24