[1]赵靖华,综述,尚美生,等.衰老与心律失常[J].心血管病学进展,2016,(2):121-124.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.006]
 ZHAO Jinghua,SHANG Meisheng,YAO Yan.Aging and Arrhythmias[J].Advances in Cardiovascular Diseases,2016,(2):121-124.[doi:10.16806/j.cnki.issn.1004-3934.2016.02.006]
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衰老与心律失常()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2016年2期
页码:
121-124
栏目:
综述
出版日期:
2016-04-20

文章信息/Info

Title:
Aging and Arrhythmias
作者:
赵靖华综述尚美生姚艳审校
北京市心肺血管疾病研究所 首都医科大学附属北京安贞医院心内科,100029 北京
Author(s):
ZHAO Jinghua SHANG Meisheng YAO Yan
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases,Beijing 100029,China
关键词:
心律失常 衰老 发病机制 治疗
Keywords:
Aging Arrhythmia Pathogenesis Treatment
分类号:
R541.7
DOI:
10.16806/j.cnki.issn.1004-3934.2016.02.006
文献标志码:
A
摘要:
衰老是多种心血管疾病发生发展的独立危险因素。随着老年化的进展,机体出现窦房结起搏细胞进行性减少,心肌细胞及间质纤维化明显增加,钠、钾、钙离子通道表达和功能异常,缝隙连接蛋白表达及分布异常,及由microRNA调控的心脏电重构等一系列心脏结构及电生理改变,心律失常的发病率和病死率显著增加,且针对老年性心律失常的防治亦有其特殊性,现就衰老与心律失常做一综述。
Abstract:
Aging is an independent risk factor for the development of a variety of cardiovascular diseases.With the aging process, a series of cardiac structure and electrophysiological changes appear, such as progressive reduction of sinus pacemaker cells, significantly increasing fibrosis, Na+, K+, Ca2+ channel dysfunction, the decline of connexins, and cardiac electrical remodeling regulated by microRNA.Arrhythmia morbidity and mortality increased significantly and the prevention and treatment of senile arrhythmia requires its own specific particularities.This paper gives a review of aging and arrhythmia.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目( 81200141); 北京市科技新星计划(2011081) 作者简介:赵靖华(1991—),在读硕士,主要从事心血管疾病的基础和临床研究。Email: 1126782515 @qq.com 通信作者:尚美生(1963—),主任医师 硕士生导师,博士,博士后,主要从事心血管疾病的基础和临床研究。Email: sxtysms@163.com 姚艳(1981—),主治医师,博士,博士后,主要从事心血管疾病的基础和临床研究。Email:iceyaya614@163.com
更新日期/Last Update: 2016-03-25