[1]唐光能,洪炳哲.Junctate蛋白在心力衰竭中的研究进展[J].心血管病学进展,2015,(5):629-634.[doi:10.3969/j.issn.1004-3934.2015.05.028]
 TANG Guangneng,HONG Bingzhe.Research Development of Junctate Protein in Heart Failure[J].Advances in Cardiovascular Diseases,2015,(5):629-634.[doi:10.3969/j.issn.1004-3934.2015.05.028]
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Junctate蛋白在心力衰竭中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2015年5期
页码:
629-634
栏目:
综述
出版日期:
2016-05-20

文章信息/Info

Title:
Research Development of Junctate Protein in Heart Failure
作者:
唐光能1洪炳哲2
1.十堰市太和医院,湖北 十堰 442000; 2.齐齐哈尔市第一医院,黑龙江 齐齐哈尔 161000
Author(s):
TANG Guangneng1 HONG Bingzhe2
1. Shiyan Taihe Hospital, Shiyan 442000, Hubei, China; 2. The First Hospital of Qiqihaer City, Qiqihaer 161000, Heilongjiang, China
关键词:
junctate蛋白 心力衰竭 Ca2+ 兰尼碱受体
Keywords:
junctate protein heart failure calcium ryanodine receptor
分类号:
Q51; R541.6+1
DOI:
10.3969/j.issn.1004-3934.2015.05.028
文献标志码:
A
摘要:
Junctate蛋白是在哺乳动物肌浆网/内质网膜上新发现的一种Ca2+结合蛋白,与兰尼碱受体相关联,是天冬氨酰β-羟化酶基因转录的五个家族成员之一。Junctate蛋白存在于多种细胞中,参与细胞内Ca2+浓度的调节。大量的动物实验观察到,过表达junctate蛋白会导致多种钙调控通道功能异常,持续过表达junctate蛋白还会导致心肌肥大、心律失常、心肌纤维化等病理改变,最终会出现心力衰竭。因此,junctate蛋白在心力衰竭中起了重要的作用,现将junctat
Abstract:
Junctate protein is a newly discovered Ca2+ binding protein in mammalian sarcoplasmic reticulum/endoplasmic reticulum membrane. It is associated with ryanodine receptor, which is one of the five members of the gene transcription of aspartate beta-hydroxylase family. Junctate protein is present in a variety of cells that is involved in the intracellular Ca2+ concentration regulation. In a large number of animal experiments, over expression of junctate protein can cause more calcium channel regulation dysfunction and pathological changes in cardiac hypertrophy, arrhythmias and myocardial fibrosis and ultimately result in heart failure. Due to the important role of junctate protein in heart failure, junctate protein studies in heart failure are reviewed.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(30600240; 31070998) 作者简介:唐光能(1986—),住院医师,硕士,主要从事心血管药理学研究。Email:tanggn2013@163.com.cn 通信作者:洪炳哲(1973—),副主任医师,研究生导师,博士。Email:hongbingzhe73@163.com.cn
更新日期/Last Update: 2016-05-20