[1]成哲,罗素新,夏勇.LCZ696在心血管疾病中的研究进展[J].心血管病学进展,2015,(5):606-610.[doi:10.3969/j.issn.1004-3934.2015.05.021]
 CHENG Zhe,LUO Suxin,XIA Yong.Research Progress of LCZ696 in Cardiovascular Disease[J].Advances in Cardiovascular Diseases,2015,(5):606-610.[doi:10.3969/j.issn.1004-3934.2015.05.021]
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LCZ696在心血管疾病中的研究进展()
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《心血管病学进展》[ISSN:51-1187/R/CN:1004-3934]

卷:
期数:
2015年5期
页码:
606-610
栏目:
综述
出版日期:
2016-05-20

文章信息/Info

Title:
Research Progress of LCZ696 in Cardiovascular Disease
作者:
成哲罗素新夏勇
重庆医科大学附属第一医院心血管内科,重庆 400016
Author(s):
CHENG Zhe LUO Suxin XIA Yong
Department of Cardiology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China
关键词:
述。LCZ696 利钠肽 高血压 收缩性心力衰竭
Keywords:
LCZ696 natriuretic peptides hypertension systolic heart failure
分类号:
R541
DOI:
10.3969/j.issn.1004-3934.2015.05.021
文献标志码:
A
摘要:
LCZ696是第一个脑啡肽酶与血管紧张素受体联合阻滞的药物,脑啡肽酶能降解具有生物活性的利钠肽和其他几种血管活性物质,利钠肽具有排钠、舒张血管、阻断肾素-血管紧张素系统,降低交感张力、抗心肌细胞肥大等作用,脑啡肽酶阻滞剂可增加血浆利钠肽水平,而单独的脑啡肽酶阻滞剂并未带来临床获益,它需要与肾素-血管紧张素系统阻滞剂药物联用。多项临床研究表明,在高血压、心力衰竭的患者中使用LCZ696后,特别是在收缩性心力衰竭患者中,有显著的临床获益,现对LCZ696的机制及临床应用进展做一综述。
Abstract:
LCZ696 is a first-in-class angiotensin receptor neprilysin inhibitor. Neprilysin is an enzyme that contributes to the breakdown of the biologically active natriuretic peptides and several other vasoactive compounds.Natriuretic peptides have potent natriuretic and vasodilator properties, inhibit the activity of the renin-angiotensin system, lower sympathetic drive, and have anti-proliferative and anti-hypertrophic effects. Neprilysin inhibitor can increase the level of the natriuretic peptides in the plasma. However, studies have shown that neprilysin inhibitor alone does not result in meaningful clinical benefits. Neprilysin inhibitor should been used in combination with a renin-angiotensin system inhibition drug. The treatment of LCZ696 in hypertension and heart failure results in clinical benefits. The review summarizes the mechanism and clinical application of LCZ696.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:国家重点基础研究发展计划(2014CB542400); 国家自然科学基金面上项目(81170112,81270210); 重庆市科委课题(CSTC2012JJA10143); 国家临床重点专科建设项目经费资助[财社(2011)170号] 作者简介:成哲(1990—),住院医师,硕士,主要从事心力衰竭、冠心病研究。Email:346196500@qq.com 通信作者:罗素新,主任医师,教授,博士,硕士生导师,主要从事高血压、冠心病、心律失常、心力衰竭临床研究。Email:luosuxin0204
更新日期/Last Update: 2016-05-20